Kelly M Swinney

US Patent:

20160354316, Dec 8, 2016

Filed:

Oct 31, 2014

Appl. No.:

15/035969

Inventors:

Kelly Ann SWINNEY - Boston MA, US
Patricia Nell HURTER - Harvard MA, US
David E. NADIG - Dorchester MA, US
David SMITH - Newton MA, US
Vance Hayden THOMAS - Duxbury MA, US
Martin Paul WARMAN - Hingham MA, US
- Boston MA, US

Assignee:

VERTEX PHARMACEUTICALS INCORPORATED - Boston MA

International Classification:

A61K 9/20
A61K 31/47
A61K 31/443

Abstract:

Processes of preparing pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of administering, and kits thereof are disclosed.