Kenneth L Fish

US Patent:

7745222, Jun 29, 2010

Filed:

Oct 13, 2006

Appl. No.:

11/580493

Inventors:

Kenneth Michael Fish - Clifton Park NY, US
Cristina Tan Hehir - Niskayuna NY, US
Michael Christopher Montalto - Albany NY, US
Eric Dustin Agdeppa - Fairview NJ, US

Assignee:

General Electric Company - Niskayuna NY

International Classification:

G01N 33/48

US Classification:

436 63

Abstract:

Provided herein are amyloid-binding assays that simulate in situ brain conditions by combining binders with various A-beta species on mammalian brain tissue. In general the amyloid-binding assays comprise the steps of (a) contacting a mammalian brain tissue sample with at least one A-beta species; (b) applying a putative binder to the brain tissue sample; and (c) determining whether the putative binder binds to the A-beta species.

US Patent:

7837981, Nov 23, 2010

Filed:

Dec 11, 2006

Appl. No.:

11/609134

Inventors:

Tiberiu Mircea Siclovan - Rexford NY, US
Michael Christopher Montalto - Albany NY, US
Kenneth Michael Fish - Clifton Park NY, US
Eric Dustin Agdeppa - Fairview NJ, US
Cristina Tan Hehir - Niskayuna NY, US

Assignee:

General Electric Company - Niskayuna NY

International Classification:

A61K 51/00
A61M 36/14

US Classification:

424 169, 424 111, 424 165, 424 181, 424 185, 424 189, 424 91, 530300

Abstract:

Provided herein are agents that bind to soluble beta-amyloid. Also provided are in vivo and in vitro methods for detecting soluble beta-amyloid in a sample that may include brain tissue.

US Patent:

8114382, Feb 14, 2012

Filed:

Sep 17, 2008

Appl. No.:

12/211854

Inventors:

Cristina Abucay Tan Hehir - Niskayuna NY, US
Stephen Johnson Lomnes - Philadelphia PA, US
Kenneth Michael Fish - Clifton Park NY, US
Tiberiu Mircea Siclovan - Rexford NY, US
Michael Christopher Montalto - Albany NY, US

Assignee:

General Electric Company - Niskayuna NY

International Classification:

A61K 49/00

US Classification:

424 91, 424 111, 424 95, 424 96, 424 165, 424 181, 436 91, 436127, 436128

Abstract:

The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope derivatives. In one embodiment a method of myelin detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the benzofuran compound, or a derivative of the compound, and determining myelination in the subject by detecting binding in the sample. In one embodiment, the invention provides a method of imaging myelinated tissue in a surgical field of mammalian tissue comprising the steps of contacting the surgical site with the benzofuran compound or a radioisotope derivative of the compound, and detecting binding in the surgical site. In yet another embodiment, a method of imaging spinal cord and spinal nerve root tissue is provided comprising the steps of parenteral administration of a radioisotope derivative of the benzofuran compound and detecting the radioisotope derivative within the spinal canal and intervertebral foramen. Methods of quantification of binding of the benzofuran compound or its derivatives are also provided.

US Patent:

8357350, Jan 22, 2013

Filed:

Feb 12, 2009

Appl. No.:

12/370207

Inventors:

Cristina Abucay Tan Hehir - Niskayuna NY, US
Tiberiu Mircea Siclovan - Rexford NY, US
Kenneth Michael Fish - Clifton Park NY, US
Nicole Evelyn Barnhardt - Clifton Park NY, US
John V. Frangioni - Wayland MA, US
Carrie S. Vooght - Lowell MA, US

Assignee:

General Electric Company - Niskayuna NY

International Classification:

A61K 51/00
A61M 36/14

US Classification:

424 181, 424 111, 424 165, 424 185, 424 189, 424 96, 534 14, 546329

Abstract:

The present invention relates to methods for imaging annulus fibrosus tissue and a quantitative measurement of its local concentration in a sample using an agent comprising the compound of Formula I, a C or H enriched compound of Formula I, an F-labeled derivative of Formula I, a metal-DOTA (1,4,7,10-tetra-azacyclododecane-N,N′,N″,N′″-tetraacetic acid) complex of Formula I, or a radioisotope derivative of Formula I.

US Patent:

8617515, Dec 31, 2013

Filed:

Jun 4, 2009

Appl. No.:

12/478300

Inventors:

Cristina Abucay Tan Hehir - Niskayuna NY, US
Tiberiu Mircea Siclovan - Rexford NY, US
Nicole Evelyn Barnhardt - Clifton Park NY, US
Kenneth Michael Fish - Clifton Park NY, US
Randall Lee Carter - Clifton Park NY, US
Bruce Fletcher Johnson - Scotia NY, US

Assignee:

General Electric Company - Niskayuna NY

International Classification:

A61K 49/00
A61K 49/10
A61K 51/04
A61K 101/02
A61B 5/00
A61B 5/055

US Classification:

424 165, 424 181, 424 189, 424 91, 424 93, 424 937, 424 96, 600420

Abstract:

The present invention relates to methods for myelin basic protein detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the agent, and determining myelination in the subject by detecting binding to myelin basic protein. Methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using an agent with specific binding to myelin basic protein are also provided as is a kit containing the agent or its derivatives for use in detecting myelin basic protein.

US Patent:

20040022857, Feb 5, 2004

Filed:

Jul 31, 2002

Appl. No.:

10/209726

Inventors:

Egidijus Uzgiris - Niskayuna NY, US
Bahram Moasser - Schenectady NY, US
Kenneth Fish - Clifton Park NY, US
Joanne Smith - Ballston Lake NY, US

International Classification:

A61K009/14

US Classification:

424/486000

Abstract:

Improved methods for forming substituted polymers having a high degree of conjugation include the steps of activating a steric hindrance molecule under conditions that ensure substantially all the steric hindrance molecules are mono-activated and then reacting with a polymer. An improved method for recovering polypeptides substituted with steric hindrance molecules and having an elongate configuration removes impurities and volatiles without achieving complete dryness of the copolymer.

US Patent:

20100104513, Apr 29, 2010

Filed:

Oct 28, 2008

Appl. No.:

12/259944

Inventors:

Jens Rittscher - Ballston Lake NY, US
Umesha Perdoor Srinivas Adiga - Clifton Park NY, US
Kenneth Michael Fish - Clifton Park NY, US
Anup Sood - Clifton Park NY, US
Kathleen Bove - Ballston Lake NY, US
Evelina Roxana Loghin - Rexford NY, US

Assignee:

General Electric Company - Schenectady NY

International Classification:

A61K 49/00
G06K 9/00

US Classification:

424 91, 382128

Abstract:

The present disclosure generally relates to systems and methods for identifying the boundaries of tumors and assessing quantitatively the ability of dyes to highlight a tumor's boundary. In accordance with these methods and systems, images are taken of subjects administered agents labeled with dyes. After accessing the images, tumors are selected and routines employed to both identify the boundaries of the tumors, as well as, to quantify various aspects of the tumor boundaries. From these quantifiable descriptors the performances of the various dyes to highlight the boundaries of tumors are evaluated.

US Patent:

20100143258, Jun 10, 2010

Filed:

Dec 5, 2008

Appl. No.:

12/328802

Inventors:

Anup Sood - Clifton Park NY, US
Jason William Castle - Esperance NY, US
Evelina Roxana Loghin - Rexford NY, US
Natalie Anne Staples - Albany NY, US
Kenneth Michael Fish - Clifton Park NY, US
Randall Lee Carter - Clifton Park NY, US
Brian Duh-Lan Lee - Rexford NY, US
Kathleen Bove - Ballston Lake NY, US

Assignee:

GENERAL ELECTRIC COMPANY - SCHENECTADY NY

International Classification:

A61K 49/00
C07K 2/00

US Classification:

424 96, 530345

Abstract:

In one aspect, the present invention provides a functionalized monodisperse polylysine comprising a linear monodisperse polylysine chain comprising constituent lysine monomer residues containing appended C-Cpolyethylene glycol groups and at least one appended fluorescent dye moiety is provided.