Kenneth M Hunter

US Patent:

6476003, Nov 5, 2002

Filed:

Nov 6, 2000

Appl. No.:

09/707583

Inventors:

Frank M. Jordan - Reno NV
Ruth A. Gault - Reno NV
Kenneth W. Hunter - Reno NV

Assignee:

Immusonic, Inc. - Carson City NV

International Classification:

C07H 108

US Classification:

514 54, 53612312

Abstract:

An improved method for purifying glucan to small particle size glucan and drying the glucan to a solid such that the glucan may be re-hydrated and maintain substantially maintain a particle size of one micron or less so that it may be used in nutritional, pharmaceutical and pharmacological compositions where a dry material is desired such that a greater immunological benefit may be obtained.

US Patent:

20040127458, Jul 1, 2004

Filed:

Jul 30, 2003

Appl. No.:

10/630143

Inventors:

Kenneth Hunter - Reno NV, US
Ruth Gault - Reno NV, US
Frank Jordan - Reno NV, US

International Classification:

A61K031/715

US Classification:

514/054000

Abstract:

A microparticulate beta-glucan is used as a vaccine adjuvant for animals and humans, binding to glucan receptors on a variety of phagocytic cells to enhance their immunological functions. The particles contain about 1-10% partially deacetylated N-acetylglucosamine and are predominantly 0.3-3 microns in diameter, preferably 1-2 microns in diameter, to cause the expression of co-stimulatory molecules on antigen presenting cells (APC's). The microparticle upregulates the expression of the co-stimulatory molecule B7, based upon such microparticles containing beta-(1,3) and beta(1,6) glucan.

US Patent:

20080293580, Nov 27, 2008

Filed:

Nov 8, 2004

Appl. No.:

10/578248

Inventors:

Kenneth W. Hunter - Reno NV, US
Nelson G. Publicover - Reno NV, US

International Classification:

C40B 30/04
C40B 40/08
C07H 21/00

US Classification:

506 9, 506 17, 536 221

Abstract:

The invention provides novel oligonucleotides and methods of using the same for detection or measurement of specific nucleic acid molecules. The invention also features nucleic acid arrays comprising the oligonucleotides of the invention. An oligonucleotide of the invention comprises (1) a reporter-binding sequence capable of hybridizing to a fluorrophore-labeled reporter sequence and (2) a hairpin-forming sequence capable of forming a stem-loop. Formation of the stem-loop modifies (e.g., quenching) the fluorescence signals of the reporter sequence when the reporter sequence is hybridized to the oligonucleotide. This can be achieved, for example, by bringing one or more guanine based in the oligonucleotide into close proximity to the fluorophore(s) of the reporter sequence by virtue of the formation of the stem-loop. Disruption of the stem-loop, such as by hybridization of a target sequence to at least part of the hairpin-forming sequence, produces a detectable change in the fluorescence signals.

US Patent:

20140378675, Dec 25, 2014

Filed:

Sep 5, 2014

Appl. No.:

14/479198

Inventors:

Kenneth W. Hunter - Reno NV, US
Nelson G. Publicover - Reno NV, US

Assignee:

Board of Regents of the Nevada System of Higher Education, on behalf of the University of Nevada - Reno NV

International Classification:

C12Q 1/68

US Classification:

536 231

Abstract:

The invention provides novel oligonucleotides and methods of using the same for detection or measurement of specific nucleic acid molecules. The invention also features nucleic acid arrays comprising the oligonucleotides of the invention. An oligonucleotide of the invention comprises (1) a reporter-binding sequence capable of hybridizing to a fluorophore-labeled reporter sequence and (2) a hairpin-forming sequence capable of forming a stem-loop. Formation of the stem-loop modifies (e.g., quenching) the fluorescence signals of the reporter sequence when the reporter sequence is hybridized to the oligonucleotide. This can be achieved, for example, by bringing one or more guanine based in the oligonucleotide into close proximity to the fluorophore(s) of the reporter sequence by virtue of the formation of the stem-loop. Disruption of the stem-loop, such as by hybridization of a target sequence to at least part of the hairpin-forming sequence, produces a detectable change in the fluorescence signals.

US Patent:

20140106983, Apr 17, 2014

Filed:

Dec 13, 2013

Appl. No.:

14/105944

Inventors:

Kenneth W Hunter - Reno NV, US
Nelson G Publicover - Reno NV, US

Assignee:

Board of Regents of the Nevada System of Higher Education, on behald of the University of Nevada, - Reno NV

International Classification:

C12Q 1/68

US Classification:

506 9, 436501

Abstract:

The invention provides novel oligonucleotides and methods of using the same for detection or measurement of specific nucleic acid molecules. The invention also features nucleic acid arrays comprising the oligonucleotides of the invention. An oligonucleotide of the invention comprises (1) a reporter-binding sequence capable of hybridizing to a fluorrophore-labeled reporter sequence and (2) a hairpin-forming sequence capable of forming a stem-loop. Formation of the stem-loop modifies (e.g., quenching) the fluorescence signals of the reporter sequence when the reporter sequence is hybridized to the oligonucleotide. This can be achieved, for example, by bringing one or more guanine based in the oligonucleotide into close proximity to the fluorophore(s) of the reporter sequence by virtue of the formation of the stem-loop. Disruption of the stem-loop, such as by hybridization of a target sequence to at least part of the hairpin-forming sequence, produces a detectable change in the fluorescence signals.