Kristin Wilson Cerione

US Patent:

20130252983, Sep 26, 2013

Filed:

Sep 12, 2011

Appl. No.:

13/821834

Inventors:

Kristin Wilson Cerione - Ithaca NY, US
Richard A. Cerione - Ithaca NY, US

Assignee:

CORNELL UNIVERSITY - Ithaca NY

International Classification:

A61K 31/473
A61K 31/277
A61K 31/436
A61K 31/515
G01N 33/68
C12Q 1/34

US Classification:

514270, 435375, 435 74, 435 18, 514284, 506 10, 514520, 514291

Abstract:

A method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting activating phosphorylation of glutaminase C under conditions effective to reduce production of glutamate from glutamine. Methods for treating or preventing a condition mediated by the activating phosphorylation of glutaminase C, detecting a condition mediated by the activating phosphorylation of glutaminase C, and screening for compounds capable of treating or preventing cancer are also disclosed.

US Patent:

20140079717, Mar 20, 2014

Filed:

Feb 17, 2012

Appl. No.:

13/985740

Inventors:

Rick Cerione - Ithaca NY, US
Marc Antonyak - Ithaca NY, US
Kristin Wilson Cerione - Ithaca NY, US
Bo Li - Philadelphia PA, US

Assignee:

CORNELL UNIVERSITY - Ithaca NY

International Classification:

G01N 33/68

US Classification:

4241581, 435 74, 435 723

Abstract:

Provided are methods for characterizing microvesicles or other membranous structures. The methods involve assaying samples for microvesicles or other membranous structures, and include in certain aspects determining the presence or absence of tissue transglutaminase (tTG) and/or cross-linked fibronection (FN). The microvesicles or other membranous structures can be separated from a sample using recombinant tTG or a derivative of it, or tTG or FN binding partners. Also provided are methods for inhibiting the transfer of cargo from microvesicles which contain tTG to one or more cells. This involves administering to the individual a tTG inhibitor, such as a cell-impermeable tTG inhibitor. Also provided are compositions which contain a population of microvesicles or other membranous structures, where the population is attached to tTG or a derivative thereof, or to tTG or an FN binding partner. Kits which contain reagents and other components for carrying out the method are also provided.

US Patent:

20120220610, Aug 30, 2012

Filed:

Mar 25, 2010

Appl. No.:

13/259533

Inventors:

Richard A. Cerione - Ithaca NY, US
Jon W. Erickson - Freeville NY, US
Kristin Wilson Cerione - Ithaca NY, US
Jianbin Wang - Ithaca NY, US

Assignee:

CORNELL UNIVERSITY - Ithaca NY

International Classification:

A61K 31/515
A61K 31/4745
A61K 31/473
A61K 31/4196
A61K 31/426
A61P 35/00
C07D 221/18
C07D 471/04
C07D 405/10
C07D 249/12
C07D 239/62
C07D 277/06
C12Q 1/34
G01N 33/573
C12N 5/071

US Classification:

514270, 435375, 514285, 514284, 514384, 514365, 546 61, 546 70, 5482644, 544301, 548201, 435 18, 435 71

Abstract:

The present invention relates to a method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting glutaminase C activity in the cell or tissue under conditions effective to reduce production of glutamate from glutamine. Compounds for carrying out this method are also disclosed.

US Patent:

20200206149, Jul 2, 2020

Filed:

Jan 13, 2020

Appl. No.:

16/741635

Inventors:

- Ithaca NY, US
Jon W. Erickson - Freeville NY, US
Kristin Wilson Cerione - Ithaca NY, US
Jiabin Wang - Ithaca NY, US

International Classification:

A61K 31/00
C07D 471/04
C07D 249/12
C07D 239/62
C07D 277/06
C07D 221/18
A61K 31/4745

Abstract:

The present invention relates to a method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting glutaminase C activity in the cell or tissue under conditions effective to reduce production of glutamate from glutamine. Compounds for carrying out this method are also disclosed.