Michael J. Munchhof - Salem CT, US Laura C. Blumberg - Waterford CT, US
Assignee:
Pfizer Inc. - New York NY
International Classification:
A61K031/4439 C07D401/14
US Classification:
514338, 5462684, 5462754, 5462761
Abstract:
Novel pyrazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)-β signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer, and fibrotic diseases.
Isothiazole And Isoxazole Compounds As Transforming Growth Factor (Tgf) Inhibitors
Michael J. Munchhof - Salem CT, US Laura C. Blumberg - Waterford CT, US
Assignee:
Pfizer, Inc. - New York NY
International Classification:
A61K 31/498 C07D 401/14
US Classification:
51425505, 544353, 544354, 544355, 544356
Abstract:
Novel isothiazole and isoxazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)-β signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer, and fibrotic diseases.
Triazole Compounds As Transforming Growth Factor (Tgf) Inhibitors
Michael J. Munchhof - Salem CT, US Laura C. Blumberg - Waterford CT, US
Assignee:
Pfizer Inc. - New York NY
International Classification:
A61K 31/517 C07D 401/14
US Classification:
514259, 544284
Abstract:
Novel triazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)-β signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.
Laura C. Blumberg - Waterford CT, US Matthew F. Brown - Stonington CT, US Matthew M. Hayward - Old Lyme CT, US Gregory D. Lundquist - Salem CT, US Christopher S. Poss - North Stonington CT, US Andrei Shavnya - East Lyme CT, US
Novel pyrazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)-β signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer, and fibrotic diseases.
Imidazole Compounds As Transforming Growth Factor (Tgf) Inhibitors
Michael J. Munchhof - Salem CT, US Laura C. Blumberg - Waterford CT, US
Assignee:
Pfizer Inc. - New York NY Pfizer Products Inc. - Groton CT
International Classification:
A61K 31/44 C07D 401/04
US Classification:
514339, 5462681, 5462727, 5462741, 514336
Abstract:
Novel imidazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)-β signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.
Oxazole And Thiazole Compounds As Transforming Growth Factor (Tgf) Inhibitors
Michael J. Munchhof - Salem CT, US Laura C. Blumberg - Waterford CT, US
Assignee:
Pfizer Inc. - New York NY
International Classification:
A61K 31/44
US Classification:
546122, 5462684, 546164, 5462714, 544284, 544353
Abstract:
Novel oxazole and thiazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)-β signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.
Imidazopyrimidines As Transforming Growth Factor (Tgf) Inhibitors
Novel fused heteroaromatic compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)-β signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.
Nov 9, 2009 ... Laura Blumberg has not received any gifts yet ... Laura Blumberg added a discussion to the group Anxiety & Depression , Horsepeople coming ...