Leslie S. Johnson - Darnestown MD, US Godfrey Jonah Anderson Rainey - Silver Spring MD, US Sergey Gorlatov - Gaithersburg MD, US Laura Lerner - Foster City CA, US
Assignee:
MACROGENICS, INC. - Rockville MD
International Classification:
A61K 39/395 C07K 16/30 A61P 35/00 C12P 21/00
US Classification:
4241331, 435 696, 5303873
Abstract:
The present invention relates to Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and to methods of using such polypeptides for treating or preventing cancer and other diseases. The Fc region-containing polypeptides of the present invention are preferably immunoglobulins (e.g., antibodies), in which the Fc region comprises at least one amino acid substitution relative to the corresponding amino acid sequence of a wild type Fc region, and which is sufficient to attenuate post-translational fucosylation and mediate improved binding to an activating Fc receptor and reduced binding to an inhibitory Fc receptor. The methods of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection where either an enhanced efficacy of effector cell function mediated by FcγR is desired (e.g., cancer, infectious disease) or an inhibited effector cell response mediated by FcγR is desired (e.g., inflammation, autoimmune disease).
Polymer-Based Compositions For Extended Release Of Proteins
- Redwood City CA, US Thomas B. Ottoboni - Belmont CA, US Laura Lerner - Foster City CA, US
International Classification:
A61K 9/70 A61K 38/38 C07K 16/00 A61K 47/34
Abstract:
The present application is directed to poly(orthoester)-based formulations that are effective for the sustained delivery of one or more therapeutic proteins. The formulations additionally maintain the stability and bioactivity (i.e., significantly minimize the degradation and/or aggregation) of the protein contained in the poly(orthoester) matrix during preparation, storage and release.
Name / Title
Company / Classification
Phones & Addresses
Laura Lerner Systems Engineer
Raven Biotechnologies, Inc Commercial Physical Research · Research & Development in Biotechnology
1 Corporate Dr, South San Francisco, CA 94080 6506242600, 6506242780