Li Liu

US Patent:

6337408, Jan 8, 2002

Filed:

Mar 22, 2000

Appl. No.:

09/533368

Inventors:

Andrew Allen - Exton PA
Ann Marie Diederich - Downingtown PA
Li Liu - Collegeville PA
Wilford Mendelson - King of Prussia PA
Kevin Webb - Phoenixville PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07D30300

US Classification:

549332, 560 59, 558409, 564163

Abstract:

This invention relates to a method of preparing a compound of the following type by treating a compound of formula (II) with lithium bromide, magnesium bromide and the like.

US Patent:

6569638, May 27, 2003

Filed:

Mar 3, 2000

Appl. No.:

09/517734

Inventors:

I. Bernard Weinstein - Englewood NJ
W. Joseph Thompson - Doylestown PA
Jae-Won Soh - Cliffside Park NJ
Li Liu - Ambler PA
Han Li - Yardley PA

Assignee:

Cell Pathways, Inc - Horsham PA

International Classification:

C12Q 148

US Classification:

435 15, 435 692, 435184

Abstract:

This invention provides a method to identify compounds potentially useful for the treatment and prevention of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with its ability to elevate JNK kinase activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibition, an ability to elevate JNK kinase activity, growth inhibition and apoptosis induction are desirable for the treatment of neoplasia.

US Patent:

7112405, Sep 26, 2006

Filed:

Sep 27, 2002

Appl. No.:

10/260375

Inventors:

Eric B. Kmiec - Landenberg PA, US
Michael C. Rice - Newtown PA, US
Li Liu - Newark DE, US

Assignee:

University of Delaware - Wilmington DE

International Classification:

C12Q 1/68
G01N 33/53

US Classification:

435 6, 435 71

Abstract:

Composition and methods for enhancing oligonucleotide-directed nucleic acid sequence alteration in vivo, ex vivo and in vitro are presented. These methods and compositions involve cells and cell-free extracts with altered levels or activities of a protein from the RAD52 epistasis group, the mismatch repair group and/or the excision repair group.

US Patent:

7154670, Dec 26, 2006

Filed:

Mar 10, 2004

Appl. No.:

10/796930

Inventors:

Hongbin Zhang - Marlboro NJ, US
Li Liu - Carneys Point NJ, US
R. Brian Jander - Freehold NJ, US
Alexei N. Pilipetskii - Colts Neck NJ, US

Assignee:

Tyco Telecommunications (US) Inc. - Morristown NJ

International Classification:

G02B 27/28

US Classification:

359501, 359497, 385 11

Abstract:

Methods and apparatus of performing polarization control for optical transmissions. The methods and apparatus enable polarization control devices to achieve a desired output state of polarization regardless of the input state of polarization. The desired state of polarization can be achieved by rotating waveplates in a polarization controller in a sequential fashion. Each waveplate may be continually adjusted or dithered so long as the feedback signal satisfies a feedback condition. Once the feedback signal exceeds the feedback condition, the next waveplate in the polarization controller is adjusted. This enables the methods and apparatus to rapidly adjust the state of polarization away from dead spots and minimize loss control problems.

US Patent:

7553850, Jun 30, 2009

Filed:

Aug 2, 2005

Appl. No.:

11/195231

Inventors:

Scott Dax - Landenberg PA, US
Bart DeCorte - Southhampton PA, US
Li Liu - Doylestown PA, US
Mark McDonnell - Lansdale PA, US
James McNally - Souderton PA, US

Assignee:

Janssen Pharmaceutica NV

International Classification:

A61K 31/46

US Classification:

514304, 546126

Abstract:

Disclosed are compounds, compositions and methods for treating various diseases and conditions, including pain. Such compounds are represented by Formula I as follows:.

US Patent:

7589104, Sep 15, 2009

Filed:

Dec 21, 2005

Appl. No.:

11/313704

Inventors:

John R. Carson - Norristown PA, US
Scott L. Dax - Landenberg PA, US
Bart DeCorte - Southhampton PA, US
Li Liu - Doylestown PA, US
Mark McDonnell - Lansdale PA, US
James J. McNally - Souderton PA, US

Assignee:

Janssen Pharmaceutica NV - Beerse

International Classification:

C07D 405/04
A61K 31/46

US Classification:

514304, 546126

Abstract:

Disclosed are compounds, compositions and methods for treating various diseases and conditions, including pain. Such compounds are represented by Formula I as follows:.

US Patent:

8415341, Apr 9, 2013

Filed:

Apr 22, 2010

Appl. No.:

12/765617

Inventors:

Kristen Chevalier - Collegeville PA, US
Jose Clemente - Exton PA, US
Scott Dax - Landenberg PA, US
Chris Flores - Spring House PA, US
Li Liu - Doylestown PA, US
Mark Macielag - Spring House PA, US
Mark McDonnell - Lansdale PA, US
Marina Nelen - Spring House PA, US
Erica Nulton - Spring House PA, US
Stephen Prouty - Philadelphia PA, US
Matthew Todd - Spring House PA, US
Sui-Po Zhang - Radnor PA, US
Bin Zhu - Spring House PA, US

Assignee:

Janssen Pharmaceutica, NV

International Classification:

A61K 31/496
A61K 31/551
C07D 401/06
C07D 401/14
C07D 403/12
C07D 409/14
C07D 417/12

US Classification:

51421018, 540575, 544212, 544295, 544363, 544364, 544368, 544367

Abstract:

Disclosed are compounds, compositions and methods for treating diseases, syndromes, conditions and disorders that are affected by the inhibition of MGL, including pain. Such compounds are represented by Formula (I) as follows:.

US Patent:

8604017, Dec 10, 2013

Filed:

Dec 17, 2012

Appl. No.:

13/716705

Inventors:

Kristen Chevalier - Collegeville PA, US
Jose Clemente - West Chester PA, US
Pete Connolly - Spring House PA, US
Chris Flores - Spring House PA, US
Shu-Chen Lin - Doylestown PA, US
Li Liu - Germantown MD, US
John Mabus - East Greenville PA, US
Mark Macielag - Spring House PA, US
Mark McDonnell - Lansdale PA, US
Philip Pitis - North Wales PA, US
Yue-Mei Zhang - Spring House PA, US
Sui-Po Zhang - Malvern PA, US
Bin Zhu - Spring House PA, US

Assignee:

Janssen Pharmaceutica NV - Beerse

International Classification:

A61K 31/496
C07D 403/06
C07D 409/06

US Classification:

51421018, 544359, 544371, 544373, 544376

Abstract:

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows:.