Lian L Lam

US Patent:

20220401753, Dec 22, 2022

Filed:

Aug 10, 2022

Appl. No.:

17/818854

Inventors:

- Philadelphia PA, US
Hongtao Zhang - Paoli PA, US
Hiromichi Tsuchiya - Philadelphia PA, US
Yasuhiro Nagai - Philadelphia PA, US
Lian Lam - Philadelphia PA, US
Aaron Runkle - Philadelphia PA, US
Jeffrey Drebin - Bryn Mawr PA, US
Mei Qing Ji - Voorhees NJ, US

International Classification:

A61N 5/10

Abstract:

Disclosed herein are methods of increasing response to radiation therapy in subjects afflicted with cancer. In some embodiments, the method comprises reducing the ability of an immune suppressor cell (e.g., MDSC) to migrate to the microenvironment of the cancer. In some embodiments, the method further comprises suppressing the migration of the immune suppressor cell to a non-malignant cell and/or suppressing the malignant transformation of the non-malignant cells.

US Patent:

20200216555, Jul 9, 2020

Filed:

Jun 16, 2017

Appl. No.:

16/309969

Inventors:

- Philadelphia PA, US
Hongtao Zhang - Paoli PA, US
Zhiqiang Zhu - Philadelphia PA, US
Lian Lam - Philadelphia PA, US
Zheng Cai - Wynnewood PA, US

International Classification:

C07K 16/28
C07K 14/555
C07K 14/195
C07K 19/00
A61P 35/00

Abstract:

Disclosed herein are multifunctional antigen-binding proteins comprising at least one multifunctional recombinant protein scaffold and at least one antigen-specific binding domain, Polynucleotides encoding the multifunctional antigen-binding proteins, vectors containing the disclosed polynucleotides, and cells that have been genetically engineered to express the polynucleotide are also provided. Methods of using the multifunctional antigen-binding proteins are disclosed.

US Patent:

20180057603, Mar 1, 2018

Filed:

Feb 9, 2016

Appl. No.:

15/019924

Inventors:

Mark Greene - Penn Valley PA, US
Hongtao Zhang - Paoli PA, US
Hiromichi Tsuchiya - Philadelphia PA, US
Yasuhiro Nagai - Philadelphia PA, US
Lian Lam - Philadelphia PA, US
Aaron Runkle - Philadelphia PA, US
Jeffrey Drebin - Bryn Mawr PA, US
Mei Qing Ji - Voorhees NJ, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

C07K 16/30
A61K 38/02
A61K 39/395

Abstract:

The present invention provides a fusion proteins comprising