Lili Liu

US Patent:

6634364, Oct 21, 2003

Filed:

Dec 15, 2000

Appl. No.:

09/738590

Inventors:

Randy Westlund - Minneapolis MN
Bruce Tockman - Scandia MN
Gwen Crevensten - Minneapolis MN
Lili Liu - White Bear Lake MN
Christopher M. Zerby - New Brighton MN

Assignee:

Cardiac Pacemakers, Inc. - St. Paul MN

International Classification:

A61N 105

US Classification:

128898, 128899, 607116, 607122, 600374

Abstract:

A seal adapted for use with medical devices is provided. The medical device may be a lead having a distal tip adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity. The lead assembly in one embodiment includes an atraumatic tip. A seal is provided within the lead tip assembly, which prevents or limits further entry of fluids through the lead tip. The lead may be a left ventricular lead with a hemostasis mechanism provided therewithin.

US Patent:

7239923, Jul 3, 2007

Filed:

Aug 1, 2000

Appl. No.:

09/630000

Inventors:

Bruce Tockman - Scandia MN, US
Randy Westlund - Minneapolis MN, US
Gwen Crevensten - Minneapolis MN, US
Lili Liu - White Bear Lake MN, US
Chris Zerby - New Brighton MN, US
Jay A. Warren - North Oaks MN, US

Assignee:

Cardiac Pacemakers, Inc. - St. Paul MN

International Classification:

A61N 1/05

US Classification:

607119, 600373

Abstract:

An apparatus includes a lead body extending from a proximal end to a distal end and having an intermediate portion therebetween. The lead body includes two or more individually insulated conductors, where a first conductor traverses along less than an entire length of the lead body and a second conductor traverses from the proximal end to the distal end of the lead body. Optionally, the first conductor has a different material than the second conductor, for instance having differing electrical properties and/or differing stiffnesses. A method includes varying the stiffness of a coiled conductor assembly including winding a plurality of conductors to form the coiled conductor assembly, and pulling at least one loop of a first conductor away from the coiled conductor assembly.

US Patent:

7245973, Jul 17, 2007

Filed:

Dec 23, 2003

Appl. No.:

10/745302

Inventors:

Lili Liu - White Bear Lake MN, US
Randy Westlund - Minneapolis MN, US
Steven D. Girouard - Woodbury MN, US

Assignee:

Cardiac Pacemakers, Inc. - St. Paul MN

International Classification:

A61N 1/05

US Classification:

607120, 607122, 607127

Abstract:

A cardiac rhythm management system includes a lead assembly for intracardiac mapping, pacing, and drug delivery. The lead assembly includes an implantable endocardial lead having a proximal end for connection to an implantable cardiac rhythm management device and a distal end for disposal in an intracardiac region. The lead includes a pacing-sensing electrode and a drug delivery device, both located at or near the distal end. A lumen is within and extends throughout the lead, with an opening at or near the proximal end and another opening at or near the distal end. The lumen provides for access to the intracardiac region by a steerable stylet and a hollow needle, one at a time. The steerable stylet allows for electrophysiological mapping of the intracardiac region. The hollow needle allows for delivery of chemical, biochemical, and/or biological substance to the intracardiac region.

US Patent:

7657324, Feb 2, 2010

Filed:

Jul 14, 2003

Appl. No.:

10/617881

Inventors:

Randy Westlund - Minneapolis MN, US
Bruce Tockman - Scandia MN, US
Gwen Crevensten - Minneapolis MN, US
Lili Liu - White Bear Lake MN, US
Christopher M. Zerby - New Brighton MN, US

Assignee:

Cardiac Pacemakers, Inc. - St. Paul MN

International Classification:

A61N 1/05

US Classification:

607122, 600374

Abstract:

A seal adapted for use with medical devices is provided. The medical device may be a lead having a distal tip adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity. The lead assembly in one embodiment includes an atraumatic tip. A seal is provided within the lead tip assembly, which prevents or limits further entry of fluids through the lead tip. The lead may be a left ventricular lead with a hemostasis mechanism provided therewithin.

US Patent:

8078287, Dec 13, 2011

Filed:

Jun 8, 2007

Appl. No.:

11/760294

Inventors:

Lili Liu - White Bear Lake MN, US
Randy Westlund - Minneapolis MN, US
Steven D. Girouard - Woodbury MN, US

Assignee:

Cardiac Pacemakers, Inc. - St. Paul MN

International Classification:

A61N 1/05

US Classification:

607127, 607122

Abstract:

A cardiac rhythm management system includes a lead assembly for intracardiac mapping, pacing, and drug delivery. The lead assembly includes an implantable endocardial lead having a proximal end for connection to an implantable cardiac rhythm management device and a distal end for disposal in an intracardiac region. The lead includes a pacing-sensing electrode and a drug delivery device, both located at or near the distal end. A lumen is within and extends throughout the lead, with an opening at or near the proximal end and another opening at or near the distal end. The lumen provides for access to the intracardiac region by a steerable stylet and a hollow needle, one at a time. The steerable stylet allows for electrophysiological mapping of the intracardiac region. The hollow needle allows for delivery of chemical, biochemical, and/or biological substance to the intracardiac region.

US Patent:

8135471, Mar 13, 2012

Filed:

Aug 28, 2007

Appl. No.:

11/895999

Inventors:

Yi Zhang - Blaine MN, US
Lili Liu - Maple Grove MN, US
Kenneth C. Beck - St. Paul MN, US
Kent Lee - Shoreview MN, US
Jonathan Kwok - Denville NJ, US
Zheng Lin - Blaine MN, US

Assignee:

Cardiac Pacemakers, Inc. - St. Paul MN

International Classification:

A61N 1/36

US Classification:

607 42, 600529, 607 2, 607116

Abstract:

An inspiratory muscle stimulation system uses an implantable medical device to deliver stimulation to control diaphragmatic contractions for slower and deeper breathing, thereby conditioning and strengthening inspiratory muscles. In various embodiments, respiratory and/or cardiac performance are monitored for controlling parameters of the stimulation.

US Patent:

8340767, Dec 25, 2012

Filed:

Aug 12, 2009

Appl. No.:

12/539832

Inventors:

Lili Liu - Maple Grove MN, US
Mohan Krishnan - Shoreview MN, US
Bruce A. Tockman - Scandia MN, US
David R. Wulfman - Minneapolis MN, US

Assignee:

Cardiac Pacemakers, Inc. - Saint Paul MN

International Classification:

A61N 1/365

US Classification:

607 23, 607122

Abstract:

A cardiac rhythm management system comprises a medical electrical lead, a pressure sensing element, and an implantable pulse generator. The lead is sized to be advanced through the right atrium and coronary sinus into a coronary vein adjacent to the left ventricle. The lead includes an opening intermediate its proximal and distal ends, and a lumen extending longitudinally within the body in communication with the opening. The pressure sensing element is movably disposed in lead lumen and is dimensioned to extend through the opening in the lead, and includes a flexible, elongated conductive member having a distal end, and a pressure transducer coupled to the distal end of the conductive member. The pulse generator is configured to receive cardiac rhythm signals from the electrode and fluid pressure signals from the pressure transducer.

US Patent:

8417336, Apr 9, 2013

Filed:

May 26, 2010

Appl. No.:

12/787868

Inventors:

Barun Maskara - Blaine MN, US
Lili Liu - Maple Grove MN, US
Guy Alvarez - Lino Lakes MN, US
Scott A. Meyer - Lakeville MN, US

Assignee:

Cardiac Pacemakers, Inc. - St. Paul MN

International Classification:

A61N 1/08

US Classification:

607 9, 607 11, 607 17

Abstract:

A system and method for pacing rate control in a cardiac rhythm management (CRM) system. The method includes acquiring a pressure signal representative of coronary venous pressure (CVP) from a pressure sensor implanted within a coronary vein of the patient and generating a CVP waveform from the pressure signal. A pacing stimulus is applied to the patient's heart, and the pacing rate is increased in response to increases in patient's metabolic demand. The CVP index is monitored during the pacing rate increase, and the CRM system detects a reduction in the patient's hemodynamic performance based on the CVP index and establishes a maximum rate setting based on the pacing rate corresponding to the reduction in the patient's hemodynamic performance.