Lili S Liu

age ~69

from Vancouver, WA

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Lili Liu Phones & Addresses

Methoxyamine Potentiation Of Temozolomide Anti-Cancer Activity
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US Patent:

6465448, Oct 15, 2002
Filed:

Aug 13, 1999
Appl. No.:

09/373693
Inventors:

Stanton L. Gerson - Pepper Pike OH
Lili Liu - Euclid OH
Assignee:

Case Western Reserve University - Cleveland OH
International Classification:

A61K 3133
US Classification:

514183, 514645
Abstract:

This invention generally relates to novel compositions and methods for the treatment of certain cancers. Additionally, this invention relates to novel compositions and methods to screen drugs for the treatment of certain cancers. Specifically, the invention contemplates that temozolomide and methoxyamine, in combination or in sequence, shall be used as a treatment for certain tumors that are resistant to treatment by temozolomide alone.

Methoxyamine Combinations In The Treatment Of Cancer
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US Patent:

6635677, Oct 21, 2003
Filed:

Feb 19, 2002
Appl. No.:

10/079049
Inventors:

Stanton L. Gerson - Pepper Pike OH
Lili Liu - Euclid OH
Assignee:

Case Western Reserve University - Cleveland OH
International Classification:

A61K 3113
US Classification:

514645, 514589, 514274, 514262, 514 50, 514 49, 514 34, 514 33, 514 23
Abstract:

This invention generally relates to novel compositions and methods for the treatment of certain cancers. Additionally, this invention relates to novel compositions and methods to screen drugs for the treatment of certain cancers. Specifically, the invention contemplates that temozolomide and methoxyamine, in combination or in sequence, shall be used as a treatment for certain tumors that are resistant to treatment by temozolomide alone. Additionally, methoxyamine is contemplated for methods of treatment of cancer, wherein methoxyamine is used, in combination or in sequence, with other anticancer drugs or agents.

Alkylating Agent Combinations In The Treatment Of Cancer
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US Patent:

8324282, Dec 4, 2012
Filed:

Feb 19, 2003
Appl. No.:

10/505400
Inventors:

Stanton L. Gerson - Hunting Valley OH, US
Lili Liu - Northfield OH, US
Assignee:

Case Western Reserve University - Cleveland OH
International Classification:

A61K 31/13
A61K 31/33
US Classification:

514645, 514589, 514274, 514 33, 514 50, 514 34, 514 23
Abstract:

This application provides compositions and methods useful in the treatment of certain cancers. In part, this application is based on the recognition that certain molecules that target abasic lesions or AP sites in DNA improve, augment, or potentiate the chemotherapeutic efficacy of certain anticancer agents.

Detection And Quantification Of Abasic Site Formation In Vivo
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US Patent:

8367332, Feb 5, 2013
Filed:

Nov 2, 2009
Appl. No.:

12/610871
Inventors:

Lili Liu - Macedonia OH, US
Yanming Wang - Beachwood OH, US
Stanton Gerson - Hunting Valley OH, US
Assignee:

Case Western Reserve University - Cleveland OH
International Classification:

C12Q 1/68
C07H 21/00
US Classification:

435 61, 536 221
Abstract:

A method of measuring the efficacy of an anticancer agent in generating abasic (AP) sites in DNA of cancer cells of a subject includes administering to the subject an anticancer agent that generates AP sites in at least one cancer cell and an AP endonuclease inhibitor probe. The AP endonuclease inhibitor probe includes a detection moiety for detecting the probe in the subject. The amount of probe bound to cancer cells of the subject is then measured. The amount of probe bound to cancer cells of the subject is indicative of efficacy of the anticancer agent in generating AP sites in cancer cells of the subject.

Assay For Measurement Of Apurinic/Apyrimidinic (Ap) Sites And For Screening Ap-Site Reactive Compounds
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US Patent:

20090298077, Dec 3, 2009
Filed:

Aug 29, 2007
Appl. No.:

12/439626
Inventors:

Yan Xu - Solon OH, US
Stanton Gerson - Hunting Valley OH, US
Lili Liu - Macedonia OH, US
International Classification:

C12Q 1/68
US Classification:

435 6
Abstract:

A method of detecting abasic (AP) sites in DNA from a subject includes isolating a sample of DNA from a subject under examination, contacting the DNA with a fluorescent aldehyde reactive probe (FARP), and detecting FARP labeled AP sites in the DNA sample.

Mgmt Inhibitor Combination For The Treatment Of Neoplastic Disorders
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US Patent:

20100093647, Apr 15, 2010
Filed:

Feb 29, 2008
Appl. No.:

12/529643
Inventors:

Lili Liu - Macedonia OH, US
Stanton Gerson - Hunting valley OH, US
International Classification:

A61K 31/335
A61K 31/522
A61K 31/505
A61K 31/56
A61K 31/7068
A61P 35/00
A61P 35/02
US Classification:

514 23, 5142633, 514449, 514256, 514171
Abstract:

A method of treating a neoplastic disease in a subject includes administering to neoplastic cells of the subject an MGMT inhibitor and at least one of an antimitotic agent or a DNA damaging agent.

Antimetabolite Agent Combinations In The Treatment Of Cancer
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US Patent:

20100267657, Oct 21, 2010
Filed:

Apr 19, 2010
Appl. No.:

12/762768
Inventors:

LILI LIU - MACEDONIA OH, US
STANTON GERSON - HUNTING VALLEY OH, US
International Classification:

A61K 31/7068
A61K 31/7028
A61P 35/02
A61P 35/00
US Classification:

514 49, 514 43
Abstract:

A method treating cancer in a subject comprises administering to the subject a therapeutically effective amount of an antimetabolite agent that induces formation of AP sites in cancer cells of the subjects and an amount AP endonuclease inhibitor effective to potentiate the cytotoxicity of the antimetabolite agent to the cancer cells.

Alkylating Agent Combinations In The Treatment Of Cancer
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US Patent:

20120065145, Mar 15, 2012
Filed:

Jul 22, 2011
Appl. No.:

13/188977
Inventors:

Stanton L. Gerson - Hunting Valley OH, US
Lili Liu - Northfield OH, US
International Classification:

A61K 31/133
A61K 31/4188
A61K 31/522
A61P 35/00
A61K 38/14
A61K 31/704
A61K 31/7072
A61K 31/175
A61K 31/52
A61K 31/513
US Classification:

514 193, 51426337, 514393, 514645, 5142633, 514274, 514 34, 514 50, 514589
Abstract:

This application provides compositions and methods useful in the treatment of certain cancers. In part, this application is based on the recognition that certain molecules that target abasic lesions or AP sites in DNA improve, augment, or potentiate the chemotherapeutic efficacy of certain anticancer agents.