Lin Xu

US Patent:

7585846, Sep 8, 2009

Filed:

Nov 26, 2004

Appl. No.:

10/580803

Inventors:

Shey-Shing Sheu - Pittsford NY, US
Marion W. Anders - Pittsford NY, US
Lin Xu - Lexington MA, US
Virendra K. Sharma - Pittsford NY, US

Assignee:

University of Rochester - Rochester NY

International Classification:

A61K 37/00
A61K 31/24
C07C 229/00
C07C 205/00
C07C 261/00
C07C 269/00
C07C 271/00

US Classification:

514 19, 514540, 560 19, 560 22, 560155, 560159

Abstract:

Disclosed are hydrophilic choline/N-heterocycle ester compounds containing single amino acids, peptides, or derivatives thereof which have the potential to express anti-oxidant activity capable of reducing reactive oxygen species in cells. These compounds may be used to inhibit oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.

US Patent:

20060160748, Jul 20, 2006

Filed:

Dec 20, 2005

Appl. No.:

11/312873

Inventors:

Shey-Shing Sheu - Pittsford NY, US
Marion Anders - Pittsford NY, US
Lin Xu - Rochester NY, US
Virendra Sharma - Pittsford NY, US
Dhananjaya Nauduri - Rochester NY, US

International Classification:

A61K 38/05
A61K 31/198

US Classification:

514018000, 514562000

Abstract:

Disclosed are compounds containing single amino acids, peptides, or derivatives thereof which are selectively delivered to the mitochondria of a cell. Compounds of the invention exhibit antioxidant activity thereby reducing reactive oxygen species in cells. These compounds are useful for inhibiting oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.

US Patent:

20090298782, Dec 3, 2009

Filed:

Dec 18, 2006

Appl. No.:

12/097948

Inventors:

Shey-Shing Sheu - Pittsford NY, US
Marion W. Anders - Pittsford NY, US
Lin Xu - Lexington MA, US
Virendra K. Sharma - Pittsford NY, US
Dhananjaya Nauduri - Galveston TX, US

Assignee:

UNIVERSITY OF ROCHESTER - Rochester NY

International Classification:

A61K 38/05
A61K 31/22
A61K 31/425
C12N 5/02

US Classification:

514 19, 514551, 514365, 435375

Abstract:

Disclosed are compounds containing single amino acids, peptides, or derivatives thereof which are selectively delivered to the mitochondria of a cell. Compounds of the invention exhibit antioxidant activity thereby reducing reactive oxygen species in cells. These compounds are useful for inhibiting oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.

US Patent:

20110257107, Oct 20, 2011

Filed:

Jun 27, 2011

Appl. No.:

13/169604

Inventors:

Shey-Shing Sheu - Pittsford NY, US
Marion W. Anders - Pittsford NY, US
Lin Xu - Lexington MA, US
Virendra K. Sharma - Pittsford NY, US
Dhanajaya Nauduri - Galveston TX, US

Assignee:

University of Rochester - Rochester NY

International Classification:

A61K 38/06
A61K 31/164
C12N 5/00
A61P 39/06
C07C 323/59
C07D 277/06
A61K 31/223
A61K 31/426
C07C 323/60
C07K 5/083

US Classification:

514 219, 564154, 514616, 435375, 530331, 560147, 548201, 514550, 514365

Abstract:

Disclosed are compounds containing single amino acids, peptides, or derivatives thereof which are selectively delivered to the mitochondria of a cell. Compounds of the invention exhibit antioxidant activity thereby reducing reactive oxygen species in cells. These compounds are useful for inhibiting oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.

US Patent:

20210403556, Dec 30, 2021

Filed:

Feb 12, 2021

Appl. No.:

17/174610

Inventors:

- Cambridge MA, US
Lei Xu - Wayland MA, US
Lin Xu - Lexington MA, US

International Classification:

C07K 16/28
A61P 25/00
A61K 9/00
A61K 39/395
A61K 45/06
G01N 33/68

Abstract:

Dosage regimens, methods, compositions and kits are described herein useful for detecting and/or treating a CNS demyelinating disease.

US Patent:

20200031924, Jan 30, 2020

Filed:

Jul 12, 2017

Appl. No.:

16/316428

Inventors:

- Cambridge MA, US
Lei Xu - Wayland MA, US
Lin Xu - Lexington MA, US

International Classification:

C07K 16/28
A61K 39/395
A61K 45/06
A61P 25/00
A61K 9/00
G01N 33/68

Abstract:

Dosage regimens, methods, compositions and kits are described herein useful for detecting and/or treating a CNS demyelinating disease.

US Patent:

20160224251, Aug 4, 2016

Filed:

Jan 30, 2015

Appl. No.:

14/610428

Inventors:

LIN XU - Carlisle MA, US

International Classification:

G06F 3/06
G06F 17/30

Abstract:

A system and method for dynamic data management may receive a request from an operating system (OS) of a computer for device parameters to be provided to the OS; provide virtual Mass Storage Device (MSD) parameters, wherein the virtual MSD parameters cause the OS to determine that the device has an OS-supported file system, and wherein the device does not have an OS-supported file system; receive from the OS, based on the virtual MSD parameters, data retrieval requests, wherein each data retrieval request comprises at least a request for information regarding files of data and corresponding data management information; map data stored in the data storage medium to the data retrieval requests; and provide a virtual data map to the OS based on the mapping; wherein the virtual data map enables the OS to retrieve and manage the information regarding the files of data.