Columbia University New York, NY 2011 to 2012 Postdoctoral ScientistZhong Shan Hospital
Jun 2001 to Jun 2002 Resident Intern
Education:
Columbia University, Graduate School of Arts and Sciences New York, NY 2009 to 2011 Ph.D.Exchange StudentUniversity of California San Diego, CA 2006 to 2011 Ph.D. in Biological SciencesFudan University, Shanghai Medical College 2003 to 2006 Master in Medical SciencesFudan University, Shanghai Medical College 2003 to 2006 Master in researchFudan University, Shanghai Medical College 1999 to 2003 Bachelor in Medicine
Skills:
proficient in all molecular and cellular biology lab techniques and in data processing.
University of California, San Diego (UCSD), Division of Biological Sciences
2006 to 2000 Ph.D./Graduate research assistantUCSD, Division of Biological Sciences San Diego, CA 2007 to 2008 Teaching AssistantFudan University, Shanghai Medical College, Department of Pathogen Biology
2003 to 2006 Master/Graduate research assistantZhong Shan Hospital (Top 5 hospital in China)
Jun 2002 to Jun 2003 Resident Intern
Education:
Columbia University, Graduate School of Arts and Sciences New York, NY Jan 2009 to Jan 2011 Ph.D.(Exchanging Graduate Student)University of California, San Diego (UCSD) San Diego, CA Jan 2006 to Jan 2011 Ph.D. in Biological SciencesFudan University, Shanghai Medical College 2003 to 2006 Master in Medical SciencesFudan University, Shanghai Medical College 1999 to 2003 Bachelor in Medicine
Skills:
Proficient in all cell biology, molecular biology, neuroimaging technologies.
Dr. Xu graduated from the Fujian Med Coll, Fuzhou City, Fujian, China in 1983. She works in Wichita, KS and 1 other location and specializes in Psychiatry. Dr. Xu is affiliated with Via Christi Hospital and Via Christi-Saint Joseph Campus.
Dr. Xu graduated from the Beijing Med Univ, Beijing City, Beijing, China in 1982. She works in Hazlet, NJ and specializes in Internal Medicine. Dr. Xu is affiliated with Bayshore Community Hospital.
Disclosed are hydrophilic choline/N-heterocycle ester compounds containing single amino acids, peptides, or derivatives thereof which have the potential to express anti-oxidant activity capable of reducing reactive oxygen species in cells. These compounds may be used to inhibit oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.
Compounds For Delivering Amino Acids Or Peptides With Antioxidant Activity Into Mitochondria And Use Thereof
Shey-Shing Sheu - Pittsford NY, US Marion Anders - Pittsford NY, US Lin Xu - Rochester NY, US Virendra Sharma - Pittsford NY, US Dhananjaya Nauduri - Rochester NY, US
International Classification:
A61K 38/05 A61K 31/198
US Classification:
514018000, 514562000
Abstract:
Disclosed are compounds containing single amino acids, peptides, or derivatives thereof which are selectively delivered to the mitochondria of a cell. Compounds of the invention exhibit antioxidant activity thereby reducing reactive oxygen species in cells. These compounds are useful for inhibiting oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.
Compounds For Delivering Amino Acids Or Peptides With Antioxidant Activity Into Mitochondria And Use Thereof
Shey-Shing Sheu - Pittsford NY, US Marion W. Anders - Pittsford NY, US Lin Xu - Lexington MA, US Virendra K. Sharma - Pittsford NY, US Dhananjaya Nauduri - Galveston TX, US
Assignee:
UNIVERSITY OF ROCHESTER - Rochester NY
International Classification:
A61K 38/05 A61K 31/22 A61K 31/425 C12N 5/02
US Classification:
514 19, 514551, 514365, 435375
Abstract:
Disclosed are compounds containing single amino acids, peptides, or derivatives thereof which are selectively delivered to the mitochondria of a cell. Compounds of the invention exhibit antioxidant activity thereby reducing reactive oxygen species in cells. These compounds are useful for inhibiting oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.
Compounds For Delivering Amino Acids Or Peptides With Antioxidant Activity Into Mitochondria
Shey-Shing Sheu - Pittsford NY, US Marion W. Anders - Pittsford NY, US Lin Xu - Lexington MA, US Virendra K. Sharma - Pittsford NY, US Dhanajaya Nauduri - Galveston TX, US
Disclosed are compounds containing single amino acids, peptides, or derivatives thereof which are selectively delivered to the mitochondria of a cell. Compounds of the invention exhibit antioxidant activity thereby reducing reactive oxygen species in cells. These compounds are useful for inhibiting oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.