Linh Tung Le

US Patent:

8546108, Oct 1, 2013

Filed:

Jan 24, 2011

Appl. No.:

13/575222

Inventors:

Sanjiv Ghanshani - Irvine CA, US
Linh Q. Le - Tustin CA, US
Yi Liu - Irvine CA, US
Lance E. Steward - Irvine CA, US

Assignee:

Allergan, Inc. - Irvine CA

International Classification:

C12N 9/52

US Classification:

435 711, 435 691, 435220, 435471

Abstract:

The present specification discloses expression constructs comprising single-chain proteins comprising a di-chain loop region comprising an exogenous protease cleavage site and a protease that can cleave the exogenous protease cleavage site located within the di-chain loop, cell compositions comprising such expression construct, and intracellular methods of converting the single-chain protein into its di-chain form.

US Patent:

20110189162, Aug 4, 2011

Filed:

Dec 16, 2010

Appl. No.:

12/970239

Inventors:

Sanjiv Ghanshani - Irvine CA, US
Linh Q. Le - Tustin CA, US
Yi Liu - Irvine CA, US
Lance E. Steward - Irvine CA, US

Assignee:

ALLERGAN, INC. - Irvine CA

International Classification:

A61K 38/48
C07H 21/00
A61K 8/66
A61Q 19/08
A61P 29/00
C12N 15/63
C12N 9/52

US Classification:

424 9467, 536 232, 4353201, 435220

Abstract:

The present specification discloses modified Clostridial toxins, compositions comprising an integrated protease cleavage site-binding domain, polynucleotide molecules encoding such modified Clostridial toxins and compositions comprising di-chain forms of such modified Clostridial toxins.

US Patent:

20120170171, Jul 5, 2012

Filed:

Nov 21, 2011

Appl. No.:

13/301124

Inventors:

Woo Young Lee - Ridgewood NJ, US
Linh Le - New York NY, US
De Kong - Hoboken NJ, US
Matthew Henderson Ervin - Clarksville MD, US
Brian E. Fuchs - Hackettstown NJ, US

International Classification:

H01G 9/155
H01G 9/145
H01G 9/15
H05K 1/00

US Classification:

361502, 174254, 361503, 361523

Abstract:

An electrical component includes an inkjet-printed graphene electrode. Graphene oxide flakes are deposited on a substrate in a graphene oxide ink using an inkjet printer. The deposited graphene oxide is thermally reduced to graphene. The electrical properties of the electrode are comparable to those of electrodes made using activated carbon, carbon nanotubes or graphene made by other methods. The electrical properties of the graphene electrodes may be tailored by adding nanoparticles of other materials to the ink to serve as conductivity enhancers, spacers, or to confer pseudocapacitance. Inkjet-printing can be used to make graphene electrodes of a desired thickness in preselected patterns. Inkjet printing can be used to make highly-transparent graphene electrodes. Inkjet-printed graphene electrodes may be used to fabricate double-layer capacitors that store energy by nanoscale charge separation at the electrode-electrolyte interface (i.e., “supercapacitors”).

US Patent:

20140030759, Jan 30, 2014

Filed:

Sep 26, 2013

Appl. No.:

14/038328

Inventors:

Linh Q. Le - Tustin CA, US
Yi Liu - Irvine CA, US
Lance E. Steward - Irvine CA, US

Assignee:

Allergan, Inc. - Irvine CA

International Classification:

C12P 21/00

US Classification:

435 681

Abstract:

The present specification discloses expression constructs comprising single-chain proteins comprising a di-chain loop region comprising an exogenous protease cleavage site and a protease that can cleave the exogenous protease cleavage site located within the di-chain loop, cell compositions comprising such expression construct, and intracellular methods of converting the single-chain protein into its di-chain form.

US Patent:

20210162027, Jun 3, 2021

Filed:

Feb 3, 2021

Appl. No.:

17/166386

Inventors:

- Irvine CA, US
Joanne Wang - Irvine CA, US
Yi Liu - Irvine CA, US
Amy Brideau-Andersen - San Clemente CA, US
Lance E. Steward - Irvine CA, US
Linh Q. Le - Tustin CA, US
Edward C. Hsia - Irvine CA, US

International Classification:

A61K 38/48
A61K 8/99
A61Q 19/02
A61P 17/00
A61K 9/00

Abstract:

Methods for treating melanin-related afflictions of the skin, such as hyperpigmentation, are provided. The methods comprise administering a composition comprising BoNT/DC.

US Patent:

20180344820, Dec 6, 2018

Filed:

May 30, 2018

Appl. No.:

15/992627

Inventors:

- Irvine CA, US
Joanne Wang - Irvine CA, US
Yi Liu - Irvine CA, US
Amy Brideau-Andersen - San Clemente CA, US
Lance E. Steward - Irvine CA, US
Linh Q. Le - Tustin CA, US
Edward C. Hsai - Irvine CA, US

International Classification:

A61K 38/48
A61K 9/00
A61P 17/00

Abstract:

Methods for treating melanin-related afflictions of the skin, such as hyperpigmentation, are provided. The methods comprise administering a composition comprising BoNT/DC.

US Patent:

20160319265, Nov 3, 2016

Filed:

May 16, 2016

Appl. No.:

15/155302

Inventors:

- Irvine CA, US
Linh Q. Le - Tustin CA, US
Yi Liu - Irvine CA, US
Lance E. Steward - Irvine CA, US

International Classification:

C12N 9/52
C12N 9/50
C12N 15/70
C12P 21/06
C07K 14/33

Abstract:

The present specification discloses expression constructs comprising single-chain proteins comprising a di-chain loop region comprising an exogenous protease cleavage site and a protease that can cleave the exogenous protease cleavage site located within the di-chain loop, cell compositions comprising such expression construct, and intracellular methods of converting the single-chain protein into its di-chain form.

US Patent:

20160016802, Jan 21, 2016

Filed:

Sep 25, 2015

Appl. No.:

14/865844

Inventors:

- Hoboken NJ, US
Thomas A. Bechtold - Morristown NJ, US
Linh Tung Le - New York NY, US
Woo Young Lee - Ridgewood NJ, US

Assignee:

THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY - Hoboken NJ

International Classification:

C01B 31/04

Abstract:

Granules of graphene oxide may be produced from a dispersion of nanoscale graphene oxide sheets by a spray drying method. Such granules have a three-dimensional corrugated morphology. The complexity of the corrugations, and the s size distribution of the granules can be varied through selection of the spray-drying equipment used, and variation of the composition of the dispersion and the spray-drying parameters. Structural modifiers may be included in the graphene oxide dispersion to control the ultimate morphology of the granules. The granules of graphene oxide may be thermally reduced at a moderate temperature of 220 C. to increase the granules' electrical conductivity. The reduced granules may be used to fabricate electrodes for supercapacitors. The power and energy density of such an electrode material is comparable to those of conventional/commercial activated carbon-based electrodes.