Lisa F Fitzgerald

US Patent:

6475487, Nov 5, 2002

Filed:

Sep 18, 2001

Appl. No.:

09/953956

Inventors:

Gregg A. Hastings - Westlake Village CA
Mark D. Adams - North Potomac MD
Claire M. Fraser - Potomac MD
Norman H. Lee - Woodstock MD
Ewen F. Kirkness - Olney MD
Judith A. Blake - Laurel MD
Lisa M. Fitzgerald - Germantown MD
Fred H Drake - Glenmore PA
Maxine Gowan - Valley Forge PA

Assignee:

Human Genome Sciences, Inc. - Rockville MD
SmithKline Beecham Corporation - Philadelphia PA

International Classification:

A61K 39395

US Classification:

4241301, 435 691, 4352523, 43525411, 4353201, 536 232, 536 243

Abstract:

Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases. A patient is treated by administering an antibody produced against a polypeptide consisting of SEQ ID NO: 2.

US Patent:

6680375, Jan 20, 2004

Filed:

Apr 3, 2002

Appl. No.:

10/114464

Inventors:

Gregg A. Hastings - Westlake Village CA
Mark D. Adams - North Potomac MD
Claire M. Fraser - Potomac MD
Norman H. Lee - Woodstock MD
Ewen F. Kirkness - Olney MD
Judith A. Blake - Laurel MD
Lisa M. Fitzgerald - Germantown MD
Fred H. Drake - Glenmore PA
Maxine Gowan - Valley Forge PA

Assignee:

Human Genome Sciences, Inc. - Rockville MD
SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07K 1600

US Classification:

5303891, 5303881, 5303911, 5303871

Abstract:

Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.

US Patent:

6994978, Feb 7, 2006

Filed:

Dec 4, 2003

Appl. No.:

10/726645

Inventors:

Gregg A. Hastings - Westlake Village CA, US
Mark D. Adams - North Potomac MD, US
Claire M. Fraser - Potomac MD, US
Norman H. Lee - Woodstock MD, US
Ewen F. Kirkness - Olney MD, US
Judith A. Blake - Laurel MD, US
Lisa M. Fitzgerald - Germantown MD, US
Fred H. Drake - Glenmore PA, US
Maxine Gowan - Valley Forge PA, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD
SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C01N 33/53
C07K 16/00

US Classification:

435 71, 5303891, 5303881, 5303911

Abstract:

Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.

US Patent:

7235371, Jun 26, 2007

Filed:

Jul 21, 2005

Appl. No.:

11/185877

Inventors:

Gregg A. Hastings - Westlake Village CA, US
Mark D. Adams - Cleveland Heights OH, US
Claire M. Fraser - Potomac MD, US
Norman H. Lee - Rockville MD, US
Ewen F. Kirkness - Olney MD, US
Judith A. Blake - Laurel MD, US
Lisa M. Fitzgerald - Germantown MD, US
Fred H. Drake - Glenmore PA, US
Maxine Gowan - Valley Forge PA, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD
SmithKline Beecham Corp. - Philadelphia PA

International Classification:

C01N 33/53
C07K 16/00

US Classification:

435 71, 5303881, 5303891, 5303911

Abstract:

Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.

US Patent:

20080317754, Dec 25, 2008

Filed:

Jun 1, 2007

Appl. No.:

11/756638

Inventors:

Gregg A. Hastings - Westlake Village CA, US
Mark D. Adams - Cleveland Heights OH, US
Claire M. Fraser - Potomac MD, US
Norman H. Lee - Rockville MD, US
Ewen F. Kirkness - Olney MD, US
Judith A. Blake - Laurel MD, US
Lisa M. Fitzgerald - Germantown MD, US
Fred H. Drake - Glenmore PA, US
Maxine Gowan - Valley Forge PA, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD
SmithKline Beecham Corp. - Philadelphia PA

International Classification:

A61K 39/395
C12N 15/11
C12N 15/00
C12N 1/20
C12P 21/04
G01N 33/53
A61P 31/00
C12N 9/50
C07K 16/18
A61K 38/43
A61K 31/7088

US Classification:

4241391, 536 232, 4353201, 43525233, 435 691, 435219, 5303879, 424 9463, 514 44, 435 71

Abstract:

Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.