Lisa Liu

US Patent:

20230065628, Mar 2, 2023

Filed:

Feb 19, 2021

Appl. No.:

17/759592

Inventors:

- Boston MA, US
Paul Brown - Boston MA, US
Chase Spenser Coffman - Newton MA, US
James W. Ivey - Reading MA, US
Lisa Liu - Somerville MA, US
Shankul Vartak - Cambridge MA, US

International Classification:

A61K 9/16
C07K 16/28

Abstract:

The present disclosure relates to compositions and methods that enable the formation of pharmaceutically relevant particles that can be used for therapy. In particular, the methods disclosed herein allow the controlled formation of circular particles having low internal void spaces comprising bioactive therapeutic biologies.

US Patent:

20210322317, Oct 21, 2021

Filed:

Jun 30, 2021

Appl. No.:

17/364770

Inventors:

- Boston MA, US
Paul Brown - Boston MA, US
Daniel Benjamin Dadon - East Boston MA, US
Lisa Liu - Somerville MA, US
Cory Robinson - Cambridge MA, US

International Classification:

A61K 9/14
B01J 2/06

Abstract:

The invention provides methods for the preparation of particles including one or more agents, e.g., therapeutic or diagnostic agents. The particles can be formed by creating droplets of a first liquid, e.g., including an agent, and removing the first liquid, e.g., through its dispersal in a second liquid and/or evaporation, to solidify the droplets. Advantageously, the process of forming the particles does not significantly alter the structure or activity of the agents and may enhance the stability of the agents. For example, the particles may be stored for long periods of time without significant loss of activity, and in some embodiments, without the need for refrigeration. These particles may be used to generate stabilized pharmaceutical compositions for storage or other logistical purposes, pharmaceutical suspensions, pharmaceutical powder formulations (e.g., inhalable powders, injectable powders), creams or other topical pastes, nutraceuticals, or cosmetics.

US Patent:

20210315827, Oct 14, 2021

Filed:

Jun 18, 2021

Appl. No.:

17/351937

Inventors:

- Boston MA, US
Chase Spenser Coffman - Newton MA, US
Daniel Benjamin Dadon - East Boston MA, US
James Ivey - Somerville MA, US
Lisa Liu - Somerville MA, US
Chaitanya Sudrik - Stoneham MA, US

International Classification:

A61K 9/51
C07K 16/00

Abstract:

The present disclosure relates to compositions and methods that enable the formation of pharmaceutically relevant particles that can be used for therapy. In particular, the methods disclosed herein allow the controlled formation of circular particles having low internal void spaces comprising bioactive therapeutic agents.

US Patent:

20210220289, Jul 22, 2021

Filed:

May 24, 2019

Appl. No.:

17/058339

Inventors:

- Boston MA, US
Lyndon CHARLES, Jr. - Medford MA, US
Paul BROWN - Boston MA, US
Daniel Benjamin DADON - East Boston MA, US
Lisa LIU - Somerville MA, US
Sadiqua SHADBAR - Allston MA, US
Chaitanya SUDRIK - Cambridge MA, US

International Classification:

A61K 9/51
A61K 47/02
A61K 47/26
A61K 47/14
A61K 47/18
A61K 31/167
A61K 45/06

Abstract:

The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.

US Patent:

20200253875, Aug 13, 2020

Filed:

Jul 25, 2018

Appl. No.:

16/633097

Inventors:

- Boston MA, US
Paul Brown - Boston MA, US
Daniel Benjamin Dadon - Cambridge MA, US
Lisa Liu - Cambridge MA, US
Cory Robinson - Cambridge MA, US

International Classification:

A61K 9/14
B01J 2/06

Abstract:

The invention provides methods for the preparation of particles including one or more agents, e.g., therapeutic or diagnostic agents. The particles can be formed by creating droplets of a first liquid, e.g., including an agent, and removing the first liquid, e.g., through its dispersal in a second liquid and/or evaporation, to solidify the droplets. Advantageously, the process of forming the particles does not significantly alter the structure or activity of the agents and may enhance the stability of the agents. For example, the particles may be stored for long periods of time without significant loss of activity, and in some embodiments, without the need for refrigeration. These particles may be used to generate stabilized pharmaceutical compositions for storage or other logistical purposes, pharmaceutical suspensions, pharmaceutical powder formulations (e.g., inhalable powders, injectable powders), creams or other topical pastes, nutraceuticals, or cosmetics.

US Patent:

20200247009, Aug 6, 2020

Filed:

Jun 29, 2018

Appl. No.:

16/635090

Inventors:

- Baytown TX, US
Lisa Liu - Houston TX, US

International Classification:

B29B 7/74
B29B 7/90
B29B 7/94
B29B 7/48
C08K 5/01

Abstract:

Methods of making thermoplastic vulcanizate are provided, including the steps of (a) extruding an elastomeric component and a thermoplastic polymer component to form a dynamically vulcanized melt; (b) passing the dynamically vulcanized melt into a vessel, comprising two intermeshing, counter-rotating twin screws, to produce a uniform dynamically vulcanized melt; and (c) filtering the uniform dynamically vulcanized melt and recovering a thermoplastic vulcanizate.

US Patent:

20190374470, Dec 12, 2019

Filed:

Nov 22, 2017

Appl. No.:

16/463238

Inventors:

- Boston MA, US
Lyndon CHARLES - Medford MA, US
Paul BROWN - Boston MA, US
Daniel Benjamin DADON - Cambridge MA, US
Lisa LIU - Somerville MA, US
Cory ROBINSON - Cambridge MA, US

International Classification:

A61K 9/16
A61K 39/395
B05B 5/025

Abstract:

The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.