Lu Liu

US Patent:

6670168, Dec 30, 2003

Filed:

Oct 30, 2000

Appl. No.:

09/702029

Inventors:

Leonard Katz - Oakland CA
Lu Liu - Redwood City CA
Loleta M. Chung - San Francisco CA

Assignee:

Kosan Bioscience, Inc. - Hayward CA

International Classification:

C12N 120

US Classification:

43525235

Abstract:

Recombinant host cells that produce rapamycin analogues are constructed by deleting or modifying rapamycin biosynthetic gene cluster genes and are useful in the production of compounds used as antifungals, anticancers, immunosuppressants, and neurotrophins.

US Patent:

8129512, Mar 6, 2012

Filed:

Apr 14, 2008

Appl. No.:

12/102639

Inventors:

Genhai Zhu - San Jose CA, US
Itzhak Kurek - San Francisco CA, US
Lu Liu - Palo Alto CA, US

Assignee:

Pioneer Hi-Bred International, Inc. - Johnston IA

International Classification:

C12N 15/29
C12N 15/52
C12N 15/82
A01H 5/00
A01H 5/10

US Classification:

536 236, 4352572, 4353201, 435419, 800284

Abstract:

Methods for identifying one or more amino acid substitutions in a Rubisco large subunit polypeptide (variant) that confer increased Rubisco activity in a unicellular photosynthetic organism and transferring those substitutions to a Rubisco large subunit polypeptide of a higher plant cell are described herein. Methods and compositions for modulating plant productivity using the modified Rubisco large subunit polypeptide variants are provided. The Rubisco large subunit sequences are used in a variety of methods including increasing plant productivity in a plant. Transformed plants, plant cell, tissues, seed, and expression vectors are also provided.

US Patent:

8546648, Oct 1, 2013

Filed:

Sep 18, 2012

Appl. No.:

13/621895

Inventors:

Lu Liu - Palo Alto CA, US
Genhai Zhu - San Jose CA, US

Assignee:

Pioneer Hi Bred International Inc - Johnston IA

International Classification:

A01H 1/00
C12N 15/00
C07H 21/04
C07K 14/415
C12N 15/29
C12N 15/52
C12N 15/63

US Classification:

800295, 435 618, 435468, 435183, 435419, 4353201, 530370, 536 232, 536 236, 800278

Abstract:

The present invention provides thermostable polypeptides related to Rubisco Activase polypeptides. Nucleic acids encoding the polypeptides of the invention are also provided. Methods for using the polypeptides and nuclei acids of the invention to enhance resistance of plants to heat stress are encompassed.

US Patent:

8592649, Nov 26, 2013

Filed:

Aug 20, 2010

Appl. No.:

12/860265

Inventors:

Lu Liu - Palo Alto CA, US
Hoa Giang - Oakland CA, US
Dale F. Loussaert - Clive IA, US
Haiyin Wang - Johnston IA, US

Assignee:

Pioneer Hi Bred International Inc - Johnston IA

International Classification:

A01H 5/00
C12N 15/82
C12N 5/04
C07H 21/04

US Classification:

800298, 800278, 800306, 800312, 800320, 435419, 536 2374

Abstract:

The present invention provides methods and compositions relating to altering NT activity, nitrogen utilization efficiency and/or uptake in plants. The invention relates to a method for the production of plants with maintained or increased yield under low nitrogen fertility. The invention provides isolated nitrate transporter variant (NT variant) nucleic acids and their encoded proteins. The invention further provides recombinant expression cassettes, host cells, and transgenic plants. Plants transformed with nucleotide sequences encoding the NT variant enzyme show improved properties, for example, increased yield.

US Patent:

20010032342, Oct 18, 2001

Filed:

Mar 5, 2001

Appl. No.:

09/800123

Inventors:

Willem Stemmer - Los Gatos CA, US
Genhai Zhu - Sunnyvale CA, US
Lu Liu - Redwood City CA, US
Sergey Selifonov - Los Altos CA, US

Assignee:

Maxygen. Inc.

International Classification:

A01H005/00
C12N015/82

US Classification:

800/298000, 800/278000, 435/440000

Abstract:

The invention relates to methods and compositions for generating, modifying, adapting, and optimizing polynucleotide sequences that encode proteins having Rubisco biosynthetic enzyme activities which are useful for,introduction into plant species, agronomically-important microorganisms, and other hosts, and related aspects.

US Patent:

20020132308, Sep 19, 2002

Filed:

Aug 16, 2001

Appl. No.:

09/932254

Inventors:

Lu Liu - Redwood City CA, US
Genhai Zhu - San Jose CA, US

Assignee:

MPEP @ Page 300-M

International Classification:

C12P019/34
C12N015/82

US Classification:

435/091200, 435/468000

Abstract:

The present invention relates generally to methods and techniques for the expression of metabolic pathways, novel gene fusion constructs encoding multi-functional enzymatic domains, and related hybrid proteins.

US Patent:

20020151017, Oct 17, 2002

Filed:

Nov 9, 1999

Appl. No.:

09/437726

Inventors:

WILLEM P. C. STEMMER - LOS GATOS CA, US
GENHAI ZHU - SUNNYVALE CA, US
LU LIU - REDWOOD CITY CA, US
SERGEY A. SELIFONOV - LOS ALTOS CA, US

International Classification:

A01H005/00
C07H021/04
C12N009/02
C12N005/04

US Classification:

435/189000, 435/069100, 435/320100, 435/419000, 800/288000, 536/023200

Abstract:

The invention relates to methods and compositions for generating, modifying, adapting, and optimizing polynucleotide sequences that encode proteins having Rubisco biosynthetic enzyme activities which are useful for introduction into plant species, agronomically-important microorganisms, and other hosts, and related aspects.

US Patent:

20040224394, Nov 11, 2004

Filed:

Oct 21, 2003

Appl. No.:

10/690949

Inventors:

Leonard Katz - Oakland CA, US
Lu Liu - Redwood City CA, US
Loleta Chung - San Francesco CA, US

International Classification:

C12P017/18
A61K031/4745
C12N001/21
C07D487/14

US Classification:

435/119000, 435/252300, 540/456000

Abstract:

Recombinant host cells that produce rapamycin analogues are constructed by deleting or modifying rapamycin biosynthetic gene cluster genes and are useful in the production of compounds used as antifungals, anticancers, immunosuppressants, and neurotrophins.