Manmohan Singh

US Patent:

20220386862, Dec 8, 2022

Filed:

Aug 8, 2022

Appl. No.:

17/882682

Inventors:

- Houston TX, US
Achuth Nair - Houston TX, US
Manmohan Singh - Houston TX, US
Salavat Aglyamov - Friendswood TX, US

Assignee:

University of Houston System - Houston TX

International Classification:

A61B 3/00
A61B 3/10
A61B 3/16
A61B 5/00
A61B 8/10
A61B 8/08

Abstract:

A system and method for measuring biomechanical properties of tissues without external excitation are capable of measuring and quantifying these parameters of tissues in situ and in vivo. The system and method preferably utilize a phase-sensitive optical coherence tomography (OCT) system for measuring the displacement caused by the intrinsic heartbeat. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. Preferably, the method is used to detect tissue stiffness and to evaluate its stiffness due to intrinsic pulsatile motion from the heartbeat. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases and evaluating the efficacy of therapies.

US Patent:

20200329958, Oct 22, 2020

Filed:

Jun 22, 2020

Appl. No.:

16/907424

Inventors:

- Houston TX, US
Achuth Nair - Houston TX, US
Manmohan Singh - Houston TX, US
Salavat Aglyamov - Friendswood TX, US

Assignee:

University of Houston System - Houston TX

International Classification:

A61B 3/00
A61B 3/10
A61B 3/16
A61B 5/00
A61B 8/10
A61B 8/08

Abstract:

A system and method for measuring biomechanical properties of tissues without external excitation are capable of measuring and quantifying these parameters of tissues in situ and in vivo. The system and method preferably utilize a phase-sensitive optical coherence tomography (OCT) system for measuring the displacement caused by the intrinsic heartbeat. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. Preferably, the method is used to detect tissue stiffness and to evaluate its stiffness due to intrinsic pulsatile motion from the heartbeat. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases and evaluating the efficacy of therapies.

US Patent:

20200077881, Mar 12, 2020

Filed:

Sep 3, 2019

Appl. No.:

16/558413

Inventors:

- Houston TX, US
Jiasong Li - Houston TX, US
Manmohan Singh - Houston TX, US
Chen Wu - Houston TX, US
Salavat Aglyamov - Austin TX, US

Assignee:

University of Houston System - Houston TX

International Classification:

A61B 3/00
A61B 8/08
A61B 8/10
A61B 5/00
A61B 3/16
A61B 3/10

Abstract:

An excitation force (internal or external) and phase-sensitive optical coherence elastography (OCE) system, used in conjunction with a data analyzing algorithm, is capable of measuring and quantifying biomechanical parameters of tissues in situ and in vivo. The method was approbated and demonstrated on an example of the system that combines a pulsed ultrasound system capable of producing an acoustic radiation force on the crystalline lens surface and a phase-sensitive optical coherence tomography (OCT) system for measuring the lens displacement caused by the acoustic radiation force. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. The noninvasive measurement method also utilizes phase-stabilized swept source optical coherence elastography (PhS-SSOCE) to distinguish between tissue stiffness, such as that attributable to disease, and effects on measured stiffness that result from external factors, such as pressure applied to the tissue. Preferably, the method is used to detect tissue stiffness and to evaluate the presence of its stiffness even if it is affected by other factors such as intraocular pressure (TOP) in the case of cornea, sclera, or the lens. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases (such as keratoconus).

US Patent:

20190125185, May 2, 2019

Filed:

Dec 21, 2018

Appl. No.:

16/228979

Inventors:

Kirill V. Larin - Friendswood TX, US
Manmohan Singh - Houston TX, US
Jiasong Li - Pearland TX, US
Zhaolong Han - Shanghai, CN
Michael D. Twa - Birmingham AL, US

Assignee:

University of Houston System - Houston TX

International Classification:

A61B 3/16
A61B 3/10

Abstract:

Provided herein are systems and methods to measure the intraocular pressure, ocular tissue geometry and the biomechanical properties of an ocular tissue, such as an eye-globe or cornea, in one instrument. The system is an optical coherence tomography subsystem and an applanation tonometer subsystem housed as one instrument and interfaced with a computer for at least data processing and image display. The system utilizes an air-puff and a focused micro air-pulse to induce deformation and applanation and displacement in the ocular tissue. Pressure profiles of the air puff with applanation times are utilized to measure intraocular pressure. Temporal profiles of displacement and/or spatio-temporal profiles of a displacement-generated elastic wave are analyzed to calculate biomechanical properties.

US Patent:

20180214069, Aug 2, 2018

Filed:

Aug 25, 2016

Appl. No.:

15/748372

Inventors:

- Houston TX, US
Richard Yee - Houston TX, US
Manmohan Singh - Houston TX, US

Assignee:

University of Houston System - Houston TX

International Classification:

A61B 5/00

Abstract:

Methods and systems for providing depth-resolved real-time visual feedback to a physician during cosmetic dermal filler injections with micrometer spatial resolution utilizing a noninvasive optical coherence tomography/elastography, 2D-3D virtual and real time system. This system can be automated to direct proper volumes and viscosity of the necessary injection substances. The methods and systems allow for assessment of the elasticity of the tissue before and after the injection to evaluate the efficacy of the injection, with predetermined virtual results before and matched post injection images. The elasticity assessment method preferably utilizes a focused air-pulse to induce a micrometer scale displacement in the skin and the optical coherence tomography system to image this displacement. By utilizing a model-based reconstruction method, the viscoelasticity of the tissue at a specific measurement position can be obtained and virtual and post injection real time projections can be imaged.

US Patent:

20170290503, Oct 12, 2017

Filed:

Jun 26, 2017

Appl. No.:

15/632657

Inventors:

- Houston TX, US
Jiasong Li - Houston TX, US
Manmohan Singh - Houston TX, US
Chen Wu - Houston TX, US
Salavat Aglyamov - Austin TX, US

International Classification:

A61B 3/00
A61B 3/16
A61B 8/08
A61B 8/10
A61B 3/10
A61B 5/00

Abstract:

An excitation force (internal or external) and phase-sensitive optical coherence elastography (OCE) system, used in conjunction with a data analyzing algorithm, is capable of measuring and quantifying biomechanical parameters of tissues in situ and in vivo. The method was approbated and demonstrated on an example of the system that combines a pulsed ultrasound system capable of producing an acoustic radiation force on the crystalline lens surface and a phase-sensitive optical coherence tomography (OCT) system for measuring the lens displacement caused by the acoustic radiation force. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. The noninvasive measurement method also utilizes phase-stabilized swept source optical coherence elastography (PhS-SSOCE) to distinguish between tissue stiffness, such as that attributable to disease, and effects on measured stiffness that result from external factors, such as pressure applied to the tissue. Preferably, the method is used to detect tissue stiffness and to evaluate the presence of its stiffness even if it is affected by other factors such as intraocular pressure (IOP) in the case of cornea, sclera, or the lens. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases (such as keratoconus).

US Patent:

20160128558, May 12, 2016

Filed:

Nov 6, 2015

Appl. No.:

14/934663

Inventors:

- Houston TX, US
Jiasong Li - Houston TX, US
Manmohan Singh - Houston TX, US
Chen Wu - Houston TX, US
Salavat Aglyamov - Austin TX, US

International Classification:

A61B 3/00
A61B 8/08
A61B 5/00
A61B 8/10
A61B 3/10
A61B 3/16

Abstract:

An excitation force (internal or external) and phase-sensitive optical coherence elastography (OCE) system, used in conjunction with a data analyzing algorithm, is capable of measuring and quantifying biomechanical parameters of tissues in situ and in vivo. The method was approbated and demonstrated on an example of the system that combines a pulsed ultrasound system capable of producing an acoustic radiation force on the crystalline lens surface and a phase-sensitive optical coherence tomography (OCT) system for measuring the lens displacement caused by the acoustic radiation force. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. The noninvasive measurement method also utilizes phase-stabilized swept source optical coherence elastography (PhS-SSOCE) to distinguish between tissue stiffness, such as that attributable to disease, and effects on measured stiffness that result from external factors, such as pressure applied to the tissue. Preferably, the method is used to detect tissue stiffness and to evaluate the presence of its stiffness even if it is affected by other factors such as intraocular pressure (IOP) in the case of cornea, sclera, or the lens. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases (such as keratoconus).