Marc W Graham

US Patent:

8100850, Jan 24, 2012

Filed:

Apr 9, 2009

Appl. No.:

12/384898

Inventors:

Buket Grau - Arlington MA, US
David Robert Gale - Cambridge, GB
Sam Anne Musgrave - Cambridge, GB
George McGee Perkins - Cambridge, GB
Mark Jeffrey Edhouse - Levin, NZ
Marc Graham - Somerville MA, US
Christopher Kadamus - Jamaica Plain MA, US

Assignee:

E2 LLC - Morris Plains NJ

International Classification:

A61M 5/00
A61B 17/08

US Classification:

604 9, 604 8, 606153

Abstract:

A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having at least one axially-aligned annular flange defining a central opening and a support having a rim and a support surface. The support may be disposed in a nested position wherein the support surface is disposed within the central opening and an inverted position wherein the support surface is disposed away from the central opening. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its inverted and nested positions. Insertion and removal systems are also provided for use with the pyloric valve.

US Patent:

8142385, Mar 27, 2012

Filed:

Apr 9, 2009

Appl. No.:

12/384890

Inventors:

Buket Grau - Arlington MA, US
David Robert Gale - Cambridge, GB
Sam Anne Musgrave - Cambridge, GB
George McGee Perkins - Cambridge, GB
Mark Jeffrey Edhouse - Levin, NZ
Marc Graham - Somerville MA, US
Christopher Kadamus - Jamaica Plain MA, US

Assignee:

E2 LLC - Morris Plains NJ

International Classification:

A61M 5/00
A61F 2/04

US Classification:

604 8, 604 9, 623 2365, 623 2368

Abstract:

A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having a disc-shaped inlet and a helical flange. The helical flange may be disposed in a contracted position defining a contracted length and a contracted diameter and an extended position defining an extended length and an extended diameter, wherein the extended length is longer than the contracted length and the extended diameter is smaller than the contracted diameter. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its contracted and extended positions. Insertion and removal systems are also provided for use with the pyloric valve.

US Patent:

8182442, May 22, 2012

Filed:

Apr 9, 2009

Appl. No.:

12/384889

Inventors:

Buket Grau - Arlington MA, US
David Robert Gale - Cambridge, GB
Sam Anne Musgrave - Cambridge, GB
George McGee Perkins - Cambridge, GB
Mark Jeffrey Edhouse - Levin, NZ
Marc Graham - Somerville MA, US
Christopher Kadamus - Jamaica Plain MA, US

Assignee:

ElectroCore LLC - Morris Plains NJ

International Classification:

A61M 5/00
A61B 17/08
A61F 2/04

US Classification:

604 9, 606153, 623 2365

Abstract:

A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having a plurality of disc-shaped flanges connected in series. The blocking portion may be disposed in a contracted position wherein the plurality of disc-shaped flanges is disposed in a stacked configuration and a resting position wherein the plurality of disc-shaped flanges is disposed in a linear configuration. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its resting and contracted positions. Insertion and removal systems are also provided for use with the pyloric valve.

US Patent:

8226593, Jul 24, 2012

Filed:

Apr 8, 2009

Appl. No.:

12/420219

Inventors:

Marc Graham - Somerville MA, US
Buket Grau - Arlington MA, US

Assignee:

E2 LLC - Morris Plains NJ

International Classification:

A61M 5/00
A61F 2/04

US Classification:

604 9, 604 8, 623 2368

Abstract:

A pyloric valve for regulating the flow of fluids in the pyloric region a patient's gastrointestinal tract is disclosed herein. In one embodiment, a pyloric valve includes a plurality of axially connected blocking members located along a longitudinal axis of the valve in a proximal to distal direction. Each blocking member of the valve preferably includes at least one blocking portion defining at least one entryway adapted to receive fluids such as chyme therethrough. The at least one entryway of each blocking member is preferably not aligned with the at least one entryway of each blocking member adjacent thereto along the longitudinal axis. The non-alignment of the at least one entryways of the blocking members preferably creates a non-linear path for fluids such as chyme to travel through the pyloric region of the patient.

US Patent:

8517972, Aug 27, 2013

Filed:

Jun 22, 2012

Appl. No.:

13/530253

Inventors:

Marc Graham - Somerville MA, US
Buket Grau - Arlington MA, US

Assignee:

E2 LLC - Morris Plains NJ

International Classification:

A61F 2/04

US Classification:

604 8, 623 2368

Abstract:

A pyloric valve for regulating the flow of fluids in the pyloric region a patient's gastrointestinal tract is disclosed herein. In one embodiment, a pyloric valve includes a plurality of axially connected blocking members located along a longitudinal axis of the valve in a proximal to distal direction. Each blocking member of the valve preferably includes at least one blocking portion defining at least one entryway adapted to receive fluids such as chyme therethrough. The at least one entryway of each blocking member is preferably not aligned with the at least one entryway of each blocking member adjacent thereto along the longitudinal axis. The non-alignment of the at least one entryways of the blocking members preferably creates a non-linear path for fluids such as chyme to travel through the pyloric region of the patient.

US Patent:

8579849, Nov 12, 2013

Filed:

Feb 1, 2012

Appl. No.:

13/363509

Inventors:

Buket Grau - Arlington MA, US
David Robert Gale - Cambridge, GB
Sam Anne Musgrave - Cambridge, GB
George McGee Perkins - Cambridge, GB
Mark Jeffrey Edhouse - Levin, NZ
Marc Graham - Somerville MA, US
Christopher Kadamus - Jamaica Plain MA, US

Assignee:

E2 LLC - Morris Plains NJ

International Classification:

A61M 5/00
A61F 2/04

US Classification:

604 9, 604 8, 623 2365, 623 2368

Abstract:

A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having a disc-shaped inlet and a helical flange. The helical flange may be disposed in a contracted position defining a contracted length and a contracted diameter and an extended position defining an extended length and an extended diameter, wherein the extended length is longer than the contracted length and the extended diameter is smaller than the contracted diameter. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its contracted and extended positions. Insertion and removal systems are also provided for use with the pyloric valve.

US Patent:

20080125796, May 29, 2008

Filed:

Nov 28, 2007

Appl. No.:

11/998345

Inventors:

Marc Graham - Somerville MA, US

Assignee:

Stryker Development LLC - Cambridge MA

International Classification:

A61B 17/10
A61B 1/018
A61M 29/02

US Classification:

606142, 600153, 606192

Abstract:

Apparatus and methods for sealing an aperture in body tissue that extends from an outside surface to an inside surface of the body tissue is described. One embodiment of the apparatus includes an expandable material positioned against at least a portion of an expandable member, the expandable material having a sealing surface adapted to expand against the inside surface of the body tissue surrounding the aperture as the expandable member expands. In an alternative embodiment, tissue is pulled by a retractor mechanism between two biased legs of a deformable clip that is loaded on a trigger. As a base of the trigger is moved away from a base of a housing, the clip is released from the trigger causing the two biased legs of the clip to come together and seal tissue therebetween. Generally, the apparatus of each embodiment is delivered to an aperture site through an endoscope.

US Patent:

20130006381, Jan 3, 2013

Filed:

Dec 23, 2011

Appl. No.:

13/336196

Inventors:

Buket Grau - Arlington MA, US
David Robert Gale - Cambridge, GB
Sam Anne Musgrave - Cambridge, GB
George McGee Perkins - Cambridge, GB
Mark Jeffrey Edhouse - Levin, NZ
Marc Graham - Somerville MA, US
Christopher Kadamus - Jamaica Plain MA, US

Assignee:

E2 LLC - Morris Plains NJ

International Classification:

A61F 2/04

US Classification:

623 2368

Abstract:

A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having at least one axially-aligned annular flange defining a central opening and a support having a rim and a support surface. The support may be disposed in a nested position wherein the support surface is disposed within the central opening and an inverted position wherein the support surface is disposed away from the central opening. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its inverted and nested positions. Insertion and removal systems are also provided for use with the pyloric valve.