University of Nebraska Lincoln 1993 - 1998
PhD, Organic Chemistry
Skills:
Pharmaceutical Industry Biotechnology Life Sciences Drug Discovery Drug Development Validation Oncology Hplc Medicinal Chemistry Drug Design Organic Chemistry Chemistry Organic Synthesis Lc Ms
Us Patents
Haloaryl Substituted Aminopurines, Compositions Thereof, And Methods Of Treatment Therewith
Ronald J. Albers - San Diego CA, US Leticia Ayala - San Carlos CA, US Steven S. Clareen - San Diego CA, US Maria Mercedes Delgado Mederos - San Diego CA, US Robert Hilgraf - San Diego CA, US Sayee G. Hegde - San Diego CA, US Kevin Hughes - San Antonio TX, US Adam Kois - San Diego CA, US Meg McCarrick - San Diego CA, US Lisa Nadolny - San Diego CA, US Moorthy S. S. Palanki - Encinitas CA, US Kiran Sahasrabudhe - San Diego CA, US John Sapienza - Chula Vista CA, US Yoshitaka Satoh - Poway CA, US Marianne K. Sloss - San Diego CA, US Elise Sudbeck - San Diego CA, US Jonathan Wright - San Diego CA, US Ian Henderson - Hopewell NJ, US Andrew G. Cole - Robbinsville NJ, US
Assignee:
Signal Pharmaceuticals, LLC - San Diego CA Pharmacopeia Drug Discovery, Inc. - Cranbury NJ
Ronald J. Albers - San Diego CA, US Leticia Ayala - San Diego CA, US Steven S. Clareen - San Diego CA, US Maria Mercedes Delgado Mederos - San Diego CA, US Robert Hilgraf - San Diego CA, US Sayee G. Hegde - San Diego CA, US Kevin Hughes - San Antonio TX, US Adam Kois - San Diego CA, US Meg McCarrick - San Diego CA, US Lisa Nadolny - San Diego CA, US Moorthy S. S. Palanki - Encinitas CA, US Kiran Sahasrabudhe - San Diego CA, US John Sapienza - Chula Vista CA, US Yoshitaka Satoh - Poway CA, US Marianne K. Sloss - San Diego CA, US Elise Sudbeck - San Diego CA, US Jonathan Wright - San Diego CA, US
Ronald Albers - San Diego CA, US Leticia Ayala - San Diego CA, US Steven Clareen - San Diego CA, US Maria Delgado Mederos - San Diego CA, US Robert Hilgraf - San Diego CA, US Sayee Hegde - San Diego CA, US Kevin Hughes - San Antonio TX, US Adam Kois - San Diego CA, US Meg McCarrick - San Diego CA, US Lisa Nadolny - San Diego CA, US Moorthy Palanki - Encinitas CA, US Kiran Sahasrabudhe - San Diego CA, US John Sapienza - Chula Vista CA, US Yoshitaka Satoh - Poway CA, US Marianne Sloss - San Diego CA, US Elise Sudbeck - San Diego CA, US Jonathan Wright - San Diego CA, US
International Classification:
A61K 31/52 C07D 473/14
US Classification:
514263230, 544277000
Abstract:
Provided herein are Aminopurine Compounds having the following structure: wherein R, Rand Rare as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
Pyrazole Pyrazine Amine Compounds As Kinase Inhibitors, Compositions Thereof And Methods Of Treatment Therewith
Marianne Sloss - San Diego CA, US Jeffrey McKenna - Horsham, GB Won Hyung Yoon - San Diego CA, US Stephen Norris - San Diego CA, US Dale Robinson - Carlsbad CA, US Jason Parnes - San Diego CA, US Graziella Shevlin - San Diego CA, US Paul Erdman - San Diego CA, US Robert Hilgraf - San Diego CA, US Ronald Albers - San Diego CA, US Sayee Hegde - San Diego CA, US Andrew Wallace - San Diego CA, US Henry Chan - San Diego CA, US Loui Madakamutil - San Diego CA, US Heather Raymon - San Diego CA, US
International Classification:
A61K 31/497 C07D 403/12 A61P 35/00 C12N 9/99
US Classification:
51425505, 544405, 435184
Abstract:
Provided herein are Pyrazole Pyrazine Amine Compounds having the following structure:
Methods Of Treatment Comprising The Administration Of Haloaryl Substituted Aminopurines Or Compositions Thereof
Ronald J. Albers - San Diego CA, US Leticia Ayala - San Carlos CA, US Steven S. Clareen - San Diego CA, US Maria Mercedes Delgado Mederos - San Diego CA, US Robert Hilgraf - San Diego CA, US Sayee G. Hegde - San Diego CA, US Kevin Hughes - San Antonio TX, US Adam Kois - San Diego CA, US Meg McCarrick - San Diego CA, US Lisa Nadolny - San Diego CA, US Moorthy S.S. Palanki - Encinitas CA, US Kiran Sahasrabudhe - San Mateo CA, US John Sapienza - Chula Vista CA, US Yoshitaka Satoh - Poway CA, US Marianne K. Sloss - San Diego CA, US Elise Sudbeck - San Diego CA, US Jonathan Wright - San Diego CA, US Ian Henderson - Hopewell NJ, US Andrew G. Cole - Robbinsville NJ, US
Provided herein are Aminopurine Compounds having the following structure:wherein R, Rand and Rare as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
Substituted Diaminocarboxamide And Diaminocarbonitrile Pyrimidines, Compositions Thereof, And Methods Of Treatment Therewith
Brydon L. Bennett - San Diego CA, US Jan Elsner - San Diego CA, US Paul Erdman - San Diego CA, US Robert Hilgraf - San Diego CA, US Laurie Ann LeBrun - San Diego CA, US Meg McCarrick - San Diego CA, US Mehran F. Moghaddam - Carlsbad CA, US Mark A. Nagy - San Diego CA, US Stephen Norris - San Diego CA, US David A. Paisner - Portland OR, US Marianne Sloss - San Diego CA, US William J. Romanow - San Diego CA, US Yoshitaka Satoh - Poway CA, US Jayashree Tikhe - San Diego CA, US Won Hyung Yoon - San Diego CA, US Mercedes Delgado - San Diego CA, US
- San Diego CA, US Mercedes Delgado - San Diego CA, US Jan Elsner - Solana Beach CA, US Paul Erdman - San Diego CA, US Robert Hilgraf - San Diego CA, US Laurie Ann LeBrun - San Diego CA, US Meg McCarrick - San Diego CA, US Mehran F. Moghaddam - Carlsbad CA, US Mark A. Nagy - Encinitas CA, US Stephen Norris - San Diego CA, US David A. Paisner - Portland OR, US William J. Romanow - San Diego CA, US Yoshitaka Satoh - Poway CA, US Marianne Sloss - San Diego CA, US Jayashree Tikhe - San Diego CA, US Won Hyung Yoon - San Diego CA, US
Provided herein are Diaminopyrimidine Compounds having the following structures:wherein R, R, R, and Rare as defined herein, compositions comprising an effective amount of a Diaminopyrimidine Compound, and methods for treating or preventing liver fibrotic disorders or a condition treatable or preventable by inhibition of a JNK pathway.
Substituted Aminopurine Compounds, Compositions Thereof, And Methods Of Treatment Therewith
- San Diego CA, US Sogole Bahmanyar - Rancho Santa Fe CA, US John Frederick Boylan - Bedminster NJ, US Joshua Hansen - La Jolla CA, US Dehua Huang - San Diego CA, US Robert Hubbard - San Diego CA, US Brandon Jeffy - San Diego CA, US Jim Leisten - San Marcos CA, US Mehran Moghaddam - Carlsbad CA, US Raj K. Raheja - Poway CA, US Heather Raymon - San Diego CA, US Kimberly Schwarz - San Diego CA, US Marianne Sloss - San Diego CA, US Eduardo Torres - San Diego CA, US Tam Minh Tran - San Diego CA, US Shuichan Xu - San Diego CA, US JingJing Zhao - San Diego CA, US
International Classification:
A61K 31/52 C07D 473/32 A61P 35/00 A61K 31/5377
Abstract:
Provided herein are Aminopurine Compounds having the following structures:
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