Mark Andrew Cowan

Address:

1742 Dumbarton St, Mc Lean, VA 22101

Phone:

7039426992

VIN:

WMWRH33517TJ45174

Make:

MINI

Model:

COOPER

Year:

2007

US Patent:

6524271, Feb 25, 2003

Filed:

Jul 2, 2001

Appl. No.:

09/898306

Inventors:

Axel F. Brisken - Fremont CA
John R. McKenzie - San Carlos CA
Robert F. Zuk - Atherton CA
Menahem Nassi - Palo Alto CA
Mark W. Cowan - Fremont CA
Paul D. Corl - Palo Alto CA

Assignee:

Pharmasonics, Inc. - Sunnyvale CA

International Classification:

A61B 1720

US Classification:

604 22, 600466

Abstract:

A method of treating a target region in a body lumen, said method comprising: directing a uniform dose of ultrasonic energy from an interior of the lumen radially outward over a treatment length of the lumen, wherein the dosage of ultrasonic energy received at any one point along the length varies by no more than plus or minus 6 decibels from that received at any other point along the length.

US Patent:

6575956, Jun 10, 2003

Filed:

Nov 5, 1999

Appl. No.:

09/435095

Inventors:

Axel F. Brisken - Fremont CA
Robert Zuk - Atherton CA
John R. McKenzie - San Carlos CA
Mark W. Cowan - Fremont CA

Assignee:

Pharmasonics, Inc. - Sunnyvale CA

International Classification:

A61M 3100

US Classification:

604500, 604 22

Abstract:

A wide beam ultrasound delivery system providing a uniform exposure field is used to enhance the uptake of injected substances and/or to enhance the transfection of DNA in the tissues of human subject, or reduce the amount of vascular intimal hyperplasia in human subjects following vascular injury.

US Patent:

7050849, May 23, 2006

Filed:

Jun 15, 2004

Appl. No.:

10/869705

Inventors:

Debra S. Echt - Woodside CA, US
Axel F. Brisken - Fremont CA, US
Richard E. Riley - Palo Alto CA, US
Mark W. Cowan - Fremont CA, US

Assignee:

EBR Systems, Inc. - Sunnyvale CA

International Classification:

A61N 1/362

US Classification:

607 3, 607 9, 601 46

Abstract:

Systems for pacing the heart include a vibrational transducer which directs energy at the heart, usually at at least a ventricle, to pace the heart and to promote synchronized contraction of the ventricles. Optionally, additional vibrational and/or electrical stimulation may be provided. The vibrational transducers are usually implantable at a location proximate the heart.

US Patent:

7558631, Jul 7, 2009

Filed:

Sep 27, 2006

Appl. No.:

11/535857

Inventors:

Mark W. Cowan - Fremont CA, US
Debra S. Echt - Woodside CA, US
Richard E. Riley - Palo Alto CA, US
Axel F. Brisken - Fremont CA, US

Assignee:

EBR Systems, Inc. - Sunnyvale CA

International Classification:

A61N 1/368

US Classification:

607122, 607123, 607129, 128898

Abstract:

Systems including an implantable receiver-stimulator and an external controller-transmitter system are used for leadless acute stimulation of the heart, particularly after heart surgery. Cardiac pacing and arrhythmia control is accomplished with one or more implantable receiver-stimulators and an external system that alternatively includes the use of an external pacemaker. Receiver-stimulators are implanted in the heart during surgery or during an acute interventional procedure and then a triggered for stimulation by using the external system. In one embodiment of these systems, a controller-transmitter is activated by an external pacemaker to time the delivery of acoustic energy transmission through the body to a receiver-stimulator at a target tissue location. The receiver-stimulator converts the acoustic energy to electrical energy for electrical stimulation of the heart tissue.

US Patent:

7606621, Oct 20, 2009

Filed:

Dec 21, 2005

Appl. No.:

11/315524

Inventors:

Axel F. Brisken - Fremont CA, US
Mark W. Cowan - Fremont CA, US
Debra S. Echt - Woodside CA, US
Richard E. Riley - Palo Alto CA, US

Assignee:

EBR Systems, Inc. - Sunnyvale CA

International Classification:

A61N 1/00

US Classification:

607 33, 607 57

Abstract:

Receiver-stimulators comprise a nearly isotropic transducer assembly, demodulator circuitry, and at least two tissue contacting electrodes. Use of near isotropic transducers allows the devices to be implanted with less concern regarding the orientation relative to an acoustic energy source. Transducers or transducer elements having relatively small sizes, typically less than the wavelength of the acoustic source, enhance isotropy. The use of single crystal piezoelectric materials enhance sensitivity.

US Patent:

7610092, Oct 27, 2009

Filed:

Dec 21, 2005

Appl. No.:

11/315023

Inventors:

Mark W. Cowan - Fremont CA, US
Debra S. Echt - Woodside CA, US
Richard E. Riley - Palo Alto CA, US
Axel F. Brisken - Fremont CA, US

Assignee:

EBR Systems, Inc. - Sunnyvale CA

International Classification:

A61N 1/372

US Classification:

607 33, 607 9

Abstract:

Systems including an implantable receiver-stimulator and an implantable controller-transmitter are used for leadless electrical stimulation of body tissues. Cardiac pacing and arrhythmia control is accomplished with one or more implantable receiver-stimulators and an external or implantable controller-transmitter. Systems are implanted by testing external or implantable devices at different tissue sites, observing physiologic and device responses, and selecting sites with preferred performance for implanting the systems. In these systems, a controller-transmitter is activated at a remote tissue location to transmit/deliver acoustic energy through the body to a receiver-stimulator at a target tissue location. The receiver-stimulator converts the acoustic energy to electrical energy for electrical stimulation of the body tissue. The tissue locations(s) can be optimized by moving either or both of the controller-transmitter and the receiver-stimulator to determine the best patient and device responses.

US Patent:

7702392, Apr 20, 2010

Filed:

Feb 10, 2006

Appl. No.:

11/351569

Inventors:

Debra S. Echt - Woodside CA, US
Richard E. Riley - Palo Alto CA, US
Mark W. Cowan - Fremont CA, US
Axel F. Brisken - Fremont CA, US

Assignee:

EBR Systems, Inc. - Sunnyvale CA

International Classification:

A61N 1/00

US Classification:

607 27

Abstract:

Methods and apparatus for determining an endocardial implantation site for implanting an electrode, such as a leadless stimulation electrode. An embodiment of one method in accordance with the invention includes delivering sufficient electrical energy for initiation of cardiac activation to a plurality of different test locations at the heart of a patient, and determining hemodynamic responses in reaction to that the stimulus delivered to the different test locations. This method further includes identifying an implantation site for implanting the electrode by selecting at least one of the test locations corresponding to a favorable hemodynamic response.

US Patent:

7751881, Jul 6, 2010

Filed:

Jun 18, 2007

Appl. No.:

11/764546

Inventors:

Mark W. Cowan - Fremont CA, US
Axel F. Brisken - Fremont CA, US

Assignee:

EBR Systems, Inc. - Sunnyvale CA

International Classification:

A61N 1/00

US Classification:

607 5

Abstract:

An acoustic transmitter produces a pulsed ultrasound waveform which is transmitted through body tissues to an implanted receiver-stimulator device. The waveform has an acoustic amplitude, pulse width, and pulse repetition period, which corresponds to a pacing pulse electrical amplitude, pacing pulse width, and pacing cycle length, respectively. The receiver-stimulator device intercepts at least a portion of the transmitted acoustic energy and coverts that acoustic energy into electrical energy using piezoelectric or other devices. This electrical energy is applied to circuitry, which produces a desired stimulating pulse waveform, which is then applied to tissue-contacting electrodes.