Mark J Fitzgerald

US Patent:

20220372016, Nov 24, 2022

Filed:

Jun 18, 2021

Appl. No.:

17/351935

Inventors:

- Watertown MA, US
Christopher G. Nasveschuk - Stoneham MA, US
James A. Henderson - Watertown MA, US
Katrina L. Jackson - Weston MA, US
Minsheng He - Andover MA, US
Yanke Liang - Belmont MA, US
Mark E. Fitzgerald - Newton MA, US
Victoria Garza - Chelsea MA, US

Assignee:

C4 Therapeutics, Inc. - Watertown MA

International Classification:

C07D 401/14
C07D 401/04
C07D 401/10
C07D 239/22

Abstract:

This invention provides pharmaceutical protein degraders and E3 ubiquitin ligase binders for therapeutic applications as described further herein.

US Patent:

20220281891, Sep 8, 2022

Filed:

Mar 10, 2022

Appl. No.:

17/691862

Inventors:

- Cambridge MA, US
- Leverkusen, DE
- Berlin, DE
David McKinney - Cambridge MA, US
Mark Fitzgerald - Cambridge MA, US
Christopher Nasveschuk - Cambridge MA, US
Kiel Lazarski - Cambridge MA, US
Laura Furst - Cambridgge MA, US
Guo Wei - Cambridge MA, US
Patrick Ryan McCarren - Cambridge MA, US
Kai Thede - Leverkusen, DE
Anne Mengel - Leverkusen, DE
Clara Christ - Leverkusen, DE
Joachim Kuhnke - Leverkusen, DE
Sarah Anna Liesa Johannes - Leverkusen, DE
Philipp Buchgraber - Leverkusen, DE
Ulrich Klar - Leverkusen, DE
Ulrike Rauh - Leverkusen, DE
Stefan Kaulfuss - Leverkusen, DE
Amaury Ernesto Fernandez-Montalvan - Leverkusen, DE
Nicolas Werbeck - Werbeck, DE
Ursula Mönning - Leverkusen, DE

International Classification:

C07D 498/14
A61P 35/00
C07D 487/14

Abstract:

The present invention relates to macrocyclic indole derivatives of general formula (I):in which R, R, R, R, R, R, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

US Patent:

20230112244, Apr 13, 2023

Filed:

Sep 8, 2022

Appl. No.:

17/940617

Inventors:

- Leverkusen, DE
- Berlin, DE
- Cambridge MA, US
Joachim Kuhnke - Leverkusen, DE
Sarah Anna Liesa Johannes - Leverkusen, DE
Philipp Buchgraber - Leverkusen, DE
Ulrich Klar - Leverkusen, DE
Ulrike Rauh - Leverkusen, DE
Stefan Kaulfuss - Leverkusen, DE
Amaury Ernesto Fernandez-Montalvan - Leverkusen, DE
Nicolas Werbeck - Leverkusen, DE
Ursula Moenning - Leverkusen, DE
Katrin Nowak-Reppel - Leverkusen, DE
Sven Wittrock - Leverkusen, DE
David McKinney - Cambridge MA, US
Michael H. Serrano-Wu - Cambridge MA, US
Chris Lemke - Cambridge MA, US
Mark Fitzgerald - Cambridge MA, US
Christopher Nasveschuk - Cambridge MA, US
Kiel Lazarski - Cambridge MA, US
Steven James Ferrara - Cambridge MA, US
Laura Furst - Cambridge MA, US
Guo Wei - Cambridge MA, US
Patrick Ryan McCarren - Cambridge MA, US
Rebecca Ann Harvey - Lancashire, GB

International Classification:

C07D 498/14
A61P 35/02
A61P 35/00
A61K 31/4162
A61K 31/437
A61K 31/496
A61K 31/5377
A61K 45/06
C07D 471/22
C07D 487/14
C07D 487/22
C07D 498/22

Abstract:

The present invention relates to substituted macrocyclic indole derivatives of general formula (I):in which R, R, R, R, R, R, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

US Patent:

20230014124, Jan 19, 2023

Filed:

Feb 1, 2021

Appl. No.:

17/164446

Inventors:

- Watertwon MA, US
Christopher G. Nasveschuk - Syoneham MA, US
James A. Henderson - Weston MA, US
Yanke Liang - Brookline MA, US
Mark E. Fitzgerald - Watertown MA, US
Minsheng He - Watertown MA, US
Ryan E. Michael - Newton MA, US

Assignee:

C4 Therapeutics, Inc. - Watertown MA

International Classification:

A61K 47/54
C07D 403/04
A61K 31/454
A61K 31/4035
A61K 31/438
A61K 31/439
A61K 31/547
A61K 31/55

Abstract:

This invention provides heterocyclic compounds that bind to E3 Ubiquitin Ligase (typically through cereblon) (“Degrons”), which can be used as is or linked to a Targeting Ligand for a selected Target Protein for therapeutic purposes and methods of use and compositions thereof as well as methods for their preparation.

US Patent:

20210292341, Sep 23, 2021

Filed:

Nov 15, 2018

Appl. No.:

16/764672

Inventors:

- Cambridge MA, US
- Leverkusen, DE
- Berlin, DE
David McKinney - Cambridge MA, US
Mark Fitzgerald - Cambridge MA, US
Christopher Nasveschuk - Cambridge MA, US
Kiel Lazarski - Cambridge MA, US
Steven James Ferrara - Cambridge MA, US
Guo Wei - Cambridge MA, US
Patrick Ryan McCarren - Cambridge MA, US
Kai Thede - Leverkusen, DE
Anne Mengel - Leverkusen, DE
Clara Christ - Leverkusen, DE
Joachim Kuhnke - Leverkusen, DE
Sarah Anna Liesa Johannes - Leverkusen, DE
Philipp Buchgraber - Leverkusen, DE
Ulrich Klar - Leverkusen, DE
Ulrike Sack - Leverkusen, DE
Stefan Kaulfuss - Leverkusen, DE
Amaury Ernesto Fernandez-Montalvan - Leverkusen, DE
Nicolas Werbeck - Leverkusen, DE
Ursula Mönning - Leverkusen, DE
Katrin Nowak-Reppel - Leverkusen, DE

International Classification:

C07D 513/14
A61K 31/5377
A61K 31/4162
A61K 31/454
A61K 45/06
A61P 35/02
A61P 35/00

Abstract:

The present invention relates to macrocyclic indole derivatives of general formula (I):in which R, R, R, R, R, R, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

US Patent:

20210277022, Sep 9, 2021

Filed:

Nov 15, 2018

Appl. No.:

16/764675

Inventors:

- Leverkusen, DE
- Berlin, DE
- Cambridge MA, US
Joachim Kuhnke - Leverkusen, DE
Sarah Anna Liesa Johannes - Leverkusen, DE
Philipp Buchgraber - Leverkusen, DE
Ulrich Klar - Leverkusen, DE
Ulrike Sack - Leverkusen, DE
Stefan Kaulfuss - Leverkusen, DE
Amaury Ernesto Fernandez-Montalvan - Leverkusen, DE
Nicolas Werbeck - Leverkusen, DE
Ursula Mönning - Leverkusen, DE
Katrin Nowak-Reppel - Leverkusen, DE
Jeremie Xavier Mortier - Leverkusen, DE
Patrick Ryan McCarren - Cambridge MA, US
Michael H. Serrano-Wu - Cambridge MA, US
Christopher Lemke - Cambridge MA, US
David McKinney - Cambridge MA, US
Mark Fitzgerald - Cambridge MA, US
Christopher Nasveschuk - Cambridge MA, US
Kiel Lazarski - Cambridge MA, US
Steven James Ferrara - Cambridge MA, US
Laura Furst - Cambridge MA, US
Guo Wei - Cambridge MA, US
Rebecca Ann Flarvey - Lancashire, GB
Daniel Payne - Oldbury, GB
Thomas Pesnot - Chester, GB
Craig Wilson - Buxton, GB

International Classification:

C07D 498/14
C07D 487/14
A61K 45/06

Abstract:

The present invention relates to macrocyclic indole derivatives of general formula (I):in which R, R, R, R, R, R, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

US Patent:

20210269456, Sep 2, 2021

Filed:

Nov 15, 2018

Appl. No.:

16/764668

Inventors:

- Leverkusen, DE
- Berlin, DE
- Cambridge MA, US
Joachim Kuhnke - Leverkusen, DE
Sarah Anna Liesa Johannes - Leverkusen, DE
Philipp Buchgraber - Leverkusen, DE
Ulrich Klar - Leverkusen, DE
Ulrike Sack - Leverkusen, DE
Stefan Kaulfuss - Leverkusen, DE
Amaury Ernesto Fernandez-Montalvan - Leverkusen, DE
Nicolas Werbeck - Leverkusen, DE
Ursula Mönning - Leverkusen, DE
Katrin Nowak-Reppel - Leverkusen, DE
Sven Wittrock - Leverkusen, DE
David McKinney - Cambridge MA, US
Michael H. Serrano-Wu - Cambridge MA, US
Christopher Lemke - Cambridge MA, US
Mark Fitzgerald - Cambridge MA, US
Christopher Nasveschuk - Cambridge MA, US
Kiel Lazarski - Cambridge MA, US
Steven James Ferrara - Cambridge MA, US
Laura Furst - Cambridge MA, US
Guo Wei - Cambridge MA, US
Patrick Ryan McCarren - Cambridge MA, US
Rebecca Ann Harvey - Lancashire, GB

International Classification:

C07D 498/14
A61K 31/4162
A61K 31/5377
C07D 498/22
C07D 487/14
C07D 471/22
C07D 487/22
A61P 35/00
A61P 35/02
A61K 45/06
A61K 31/496
A61K 31/437

Abstract:

The present invention relates to substituted macrocyclic indole derivatives of general formula (I):in which R, R, R, R, R, R, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

US Patent:

20210253598, Aug 19, 2021

Filed:

Nov 15, 2018

Appl. No.:

16/764560

Inventors:

- Leverkusen, DE
- Berlin, DE
- Cambridge MA, US
Joachim Kuhnke - Leverkusen, DE
Sarah Anna Liesa Johannes - Leverkusen, DE
Philipp Buchgraber - Leverkusen, DE
Ulrich Klar - Leverkusen, DE
Ulrike Sack - Leverkusen, DE
Stefan Kaulfuss - Leverkusen, DE
Amaury Ernesto Fernandez-Montalvan - Leverkusen, DE
Nicolas Werbeck - Leverkusen, DE
Ursula Mönning - Leverkusen, DE
Steven James Ferrara - Cambridge MA, US
Michael H. Serrano-Wu - Cambridge MA, US
Christopher Lemke - Cambridge MA, US
David McKinney - Cambridge MA, US
Mark Fitzgerald - Cambridge MA, US
Christopher Nasveschuk - Cambridge MA, US
Kiel Lazarski - Cambridge MA, US
Laura Furst - Cambridge MA, US
Guo Wei - Cambridge MA, US
Patrick Ryan MacCarren - Cambridge MA, US
Rebecca Ann Harvey - Lancashire, GB
Craig Wilson - Buxton, GB

International Classification:

C07D 498/14
A61K 45/06
C07D 498/22
A61K 31/437
A61K 31/4162
A61K 31/4985
C07D 487/14
A61K 31/424
A61P 35/00
A61P 35/02

Abstract:

The present invention relates to aryl annulated macrocyclic indole derivatives of general formula (I):in which R, R, R, R, R, R, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.