Mark W Mclaughlin

US Patent:

20090176986, Jul 9, 2009

Filed:

Apr 6, 2007

Appl. No.:

12/226126

Inventors:

Mark McLaughlin - Summit NJ, US
Michael Palucki - Hillsborough NJ, US
Karen Marcantonio - New York NY, US

International Classification:

C07D 471/04

US Classification:

546118

Abstract:

An efficient syntheses for the preparation of the intermediate 2-oxo-1-(4-piperidinyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridine dihydrochloride, and other salt forms of 2-oxo-1-(4-piperidinyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridine.

US Patent:

20100234603, Sep 16, 2010

Filed:

Mar 12, 2010

Appl. No.:

12/722779

Inventors:

Xin Linghu - Edison NJ, US
Kathleen Linn - North Brunswick NJ, US
Kevin M. Maloney - Piscataway NJ, US
Mark McLaughlin - Summit NJ, US
Gang Qian - Kendall Park NJ, US

International Classification:

C07D 211/14

US Classification:

546194

Abstract:

The present invention relates to novel substituted aryl sulfone intermediates and processes for preparing the same. An aspect of this invention relates to a process for making substituted aryl sulfone intermediates utilizing a one-pot deacylation-carbon/sulfur bond formation step. The invention also relates to a process for preparing intermediates that are used to make the compounds of formula I. Some of the advantages of the present invention include manufacturing flexibility and efficiency, high yield synthesis using a one pot deacylation and carbon-sulfur bond formation step of a thioester intermediate and the like. This and other aspects of the invention will be realized upon review of the specification as a whole.

US Patent:

20100234604, Sep 16, 2010

Filed:

Mar 12, 2010

Appl. No.:

12/722711

Inventors:

Xin Linghu - Edison NJ, US
Kathleen Linn - North Brunswick NJ, US
Kevin M. Maloney - Piscataway NJ, US
Mark McLaughlin - Summit NJ, US
Gang Qian - Kendall Park NJ, US

International Classification:

C07D 211/20
C07D 213/62

US Classification:

546248, 546294

Abstract:

The present invention relates to novel substituted aryl sulfone intermediates and processes for preparing the same. An aspect of this invention relates to a process for making substituted aryl sulfone intermediates utilizing a one-pot deacylation-carbon/sulfur bond formation step. The invention also relates to a process for preparing intermediates that are used to make the compounds of formula I. Some of the advantages of the present invention include manufacturing flexibility and efficiency, high yield synthesis using a one pot deacylation and carbon-sulfur bond formation step of a thioester intermediate and the like. This and other aspects of the invention will be realized upon review of the specification as a whole.

US Patent:

20180346429, Dec 6, 2018

Filed:

Nov 18, 2016

Appl. No.:

15/778505

Inventors:

Cheol K. CHUNG - Rahway NJ, US
Guy R. HUMPHREY - Rahway NJ, US
Zhijian LIU - Rahway NJ, US
Mark MCLAUGHLIN - Rahway NJ, US
Yingju XU - Rahway NJ, US
Younong YU - Kenilworth NJ, US
- Rahway NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 239/84

Abstract:

Disclosed herein is a novel process for preparing substituted quinazoline compounds of formula (I) using a hydrogen bonding catalyst.

US Patent:

20180093992, Apr 5, 2018

Filed:

Dec 5, 2017

Appl. No.:

15/831895

Inventors:

- Rahway NJ, US
Feng Peng - Edison NJ, US
Yonggang Chen - Westfield NJ, US
Amude Mahmoud Kassim - Fairless Hills PA, US
Cheng-yi Chen - Princeton NJ, US
Mathew Maust - Manville NJ, US
Mark McLaughlin - Summit NJ, US
Michael J. Zacuto - Jersey City NJ, US
Qinghao Chen - Edison NJ, US
Lushi Tan - Edison NJ, US
Zhiguo Jake Song - Edison NJ, US
Yang Cao - Scotch Plains NJ, US
Feng Xu - Staten Island NY, US

International Classification:

C07D 487/04
A61K 31/4162

Abstract:

A process for preparing a compound of structural Formula Ia:

US Patent:

20170334926, Nov 23, 2017

Filed:

Nov 5, 2015

Appl. No.:

15/524872

Inventors:

Daniel A. DIROCCO - Rahway NJ, US
Ian DAVIES - Rahway NJ, US
Feng PENG - Rahway NJ, US
Mark MCLAUGHLIN - Rahway NJ, US
Louis-Charles CAMPEAU - Rahway NJ, US
Yingju XU - Rahway NJ, US
- Rahway NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 498/04
B01J 31/18
B01J 35/00

Abstract:

The present invention is directed to a process for preparing Substituted Indole Compounds of Formula (I): wherein R, R, Rand Rare as defined herein. These indole compounds are useful as synthetic intermediates for making inhibitors of HCV NS5A.

US Patent:

20170158701, Jun 8, 2017

Filed:

Jul 16, 2015

Appl. No.:

15/325100

Inventors:

- Rahway NJ, US
Feng Peng - Edison NJ, US
Yonggang Chen - Westfield NJ, US
Amude Mahmoud Kassim - Fairless Hills PA, US
Cheng-yi Chen - Princeton NJ, US
Mathew Maust - Manville NJ, US
Mark McLaughlin - Summit NJ, US
Michael J. Zacuto - Jersey City NJ, US
Qinghao Chen - Edison NJ, US
Lushi Tan - Edison NJ, US
Zhiguo Jake Song - Edison NJ, US
Yang Cao - Scotch Plains NJ, US
Feng Xu - Staten Island NY, US

International Classification:

C07D 487/04
A61K 31/4162

Abstract:

A process for preparing a compound of structural Formula Ia: comprising Boc deprotection with TFA of, reductive amination of: