Mary T Samuel

US Patent:

62076612, Mar 27, 2001

Filed:

Feb 22, 1999

Appl. No.:

9/255513

Inventors:

Stacey S. Thompson - Wheeling IL
Rao Chilamkurti - Gurnee IL
Mary Samuel - Lindenhurst IL
Norma Stephens - Skokie IL

Assignee:

Baxter International Inc. - Deerfield IL

International Classification:

A61K31/43

US Classification:

514192

Abstract:

The present invention provides a premixed form of a buffered piperacillin product having a near neutral pH and capable of a shelf life of at least nine months, with freezer storage (-20. degree. C. or lower), or a refrigerated shelf life of up to 14 days at about 5. degree. C. The piperacillin may additionally contain a tazobactam component to inactivate beta-lactamases that commonly cause resistance to penicillins, allowing the piperacillin component to destroy susceptible bacteria. With the addition of dextrose, the premixed composition is physiologically isosmotic.