Michael L Fitzgerald

US Patent:

6418481, Jul 9, 2002

Filed:

Aug 3, 2000

Appl. No.:

09/632284

Inventors:

Michael D. Mancusi - Holliston MA
Joseph E. Massery - Westborough MA
Roger F. Osmond - Littleton MA
Michael J. Fitzgerald - Framingham MA

Assignee:

Storage Technology Corporation - Louisville CO

International Classification:

G06F 1516

US Classification:

709250, 709220, 709224

Abstract:

A wiring hub for interconnecting a plurality of network components to form a local area network, the wiring hub including a data signal bus and a programmable switching mechanism connected to the data signal bus. The switching mechanism includes a plurality of ports each of which can be electrically coupled to a different one of the plurality of network components so as to pass communications signals to and receive communications signals from the network component to which it is coupled. The programmable switching mechanism interconnects a selectable set of the plurality of ports together through the data signal bus and in any user selectable ordered sequence.

US Patent:

6681261, Jan 20, 2004

Filed:

Feb 1, 2002

Appl. No.:

10/061929

Inventors:

Michael D. Mancusi - Holliston MA
Joseph E. Massery - Westborough MA
Roger F. Osmond - Littleton MA
Michael J. Fitzgerald - Framingham MA

Assignee:

Storage Technology Corporation - Louisville CO

International Classification:

G06F 1516

US Classification:

709250, 709220, 709249

Abstract:

A system and method for interconnecting a plurality of network components to form a local area network (LAN) include a wiring manager having at least one port module connected to a controller via a data signal bus on a passive backplane. Each port module includes a plurality of ports which can be programmed to electrically couple selected sets of the plurality of network components without physically rerouting network cabling. A LAN management system provides a graphical user interface to communicate with the wiring manager and provide network status information and control the wiring manager to configure the network.

US Patent:

20020128215, Sep 12, 2002

Filed:

Feb 2, 2001

Appl. No.:

09/776407

Inventors:

Hans-Ulrich Thomann - Lexington MA, US
Kristen Wall - Hingham MA, US
Michael Fitzgerald - Waltham MA, US

International Classification:

A61K048/00
C12Q001/68
C07H021/04
C12N009/00
C12N005/06

US Classification:

514/044000, 435/183000, 435/325000, 435/320100, 536/023200, 435/006000

Abstract:

This invention relates to novel polymorphisms of the NAT-2 gene which can be involved in drug metabolism and various disorders.

US Patent:

20030082550, May 1, 2003

Filed:

Sep 7, 2001

Appl. No.:

09/949293

Inventors:

Hans-Ulrich Thomann - Lexington MA, US
Kristen Diamond - Duxbury MA, US
Michael FitzGerald - Waltham MA, US

International Classification:

C12Q001/68
C12N009/02
C07H021/04

US Classification:

435/006000, 435/189000, 536/023200

Abstract:

This invention relates to isolated nucleic acids comprising single nucleotide polymorphisms of the human COX-2 gene and the proteins encoded by these nucleotides. The invention also relates to pharmacogenomics. The invention provides methods of using the polymorphisms in diagnostics and therapeutics.

US Patent:

20030211504, Nov 13, 2003

Filed:

Oct 9, 2002

Appl. No.:

10/268058

Inventors:

Kim Fechtel - Arlington MA, US
Shashi Prabhakar - Burlington MA, US
Hui Huang - Newton MA, US
Michael FitzGerald - Waltham MA, US
Joann Prescott-Roy - Concord MA, US
Michelle Runge - Bedford NH, US
Huajun Wang - Newton MA, US
Rene Gibson - Bedford MA, US

International Classification:

C12Q001/68
G06F019/00
G01N033/48
G01N033/50

US Classification:

435/006000, 702/020000

Abstract:

The invention provides an automated method of identifying a plurality of different polymorphisms within two or more related nucleic acid sequences. The method consists of: (a) obtaining a data set comprising a nucleic acid sequence assembly and a plurality of sequence characteristic parameters associated with said assembly; (b) indexing said nucleic acid assembly and said plurality of sequence characteristic parameters in a database; (c) selecting a region of said nucleic acid assembly having sequence characteristic parameters indicative of a polymorphic sequence, and (d) displaying two or more nucleic acid sequences of said region, said two or more sequences identifying different polymorphisms within said nucleic acid assembly. Also provided is a method of identifying a nucleic acid containing an indel region within a set of related nucleic acid sequences. The method consists of comprising: (a) dentifying a nucleic acid within two or more related nucleic acid sequences suspected of containing an indel region, said nucleic acid containing one or more regions having a plurality of polymorphisms, and (b) determining the occurrence of two or more criteria indicating the presence of an indel region associated with said one or more regions having a plurality of polymorphisms, said occurrence characterizing said nucleic acid as containing an indel region. Further provides is a method of determining the sequence of an allele containing an indel region within a set of related nucleic acid sequences. The method consists of comprising: (a) identifying a nucleic acid containing an indel region within two or more related nucleic acid sequences; (b) generating a consensus sequence within said indel region for said two or more related nucleic acid sequences; (c) identifying a matching string to said consensus sequence within at least one of said two or more related nucleic acid sequences, and (d) subtracting said consensus sequence from said two or more related nucleic acid sequences, the presence or absence of a unique sequence in one of said related nucleic acid sequences indicating the presence of an actual indel region. The invention additionally provides an automated system for identifying a plurality of different polymorphisms within two or more related nucleic acid sequences. The system consists of: (a) a sample submission module capable of transmitting data; (b) a core statistics loading and post processing module containing sequence characteristic parameters; (c) an assembly module capable constructing sequence assemblies from sequence database extracted data; (d) a SNP prospector module capable of identifying polymorphisms; (e) a polymorphism loader submodule capable of parsing polymorphic region sequence and sequence characteristic parameters from sequence assemblies; (f) a SNP database structured to contain the information produced in steps (a) through (e), and (g) an output module for display or further manipulation of specified data in step (f).

US Patent:

20050095239, May 5, 2005

Filed:

Sep 17, 2003

Appl. No.:

10/664414

Inventors:

G. Rebeck - Washington DC, US
Amy Deng - Charlestown MA, US
Hiroaki Fukumoto - Charlestown MA, US
Michael Irizarry - Charlestown MA, US
Michael Fitzgerald - Boston MA, US

International Classification:

A61K039/395

US Classification:

424143100

Abstract:

The present invention provides methods for reducing the efflux of cholesterol and/or secreted Aβ in the brain, as well as methods for treating Alzheimer's disease, by inhibit the expression and/or activity of LXR and/or ABCA1. Compositions comprising agents for performing the methods also are provided.

US Patent:

20130012883, Jan 10, 2013

Filed:

Jul 10, 2012

Appl. No.:

13/545937

Inventors:

Michael Fitzgerald - Danvers MA, US
Kezia Fitzgerald - Danvers MA, US

International Classification:

A61M 25/02
A61M 5/32

US Classification:

604179

Abstract:

An easily removable, non-irritating stretchable sleeve or chest wrap for protecting and securing a PICC line or chest catheter tubing and cap extending externally from the insertion point. The sleeve or chest wrap is easily attached to a patient's arm or body, securing the small length of the external PICC line or the central venous catheter, protecting the tubing and cap from external contaminants, and allowing easy access to the PICC line or the central venous catheter for administration of drugs or nutrients, and access for blood draws. This sleeve allows the patient freedom of movement and is comfortable enough to prevent skin irritation over long-term usage.

US Patent:

62758640, Aug 14, 2001

Filed:

Aug 23, 1994

Appl. No.:

8/294882

Inventors:

Michael D. Mancusi - Holliston MA
Joseph E. Massery - Westborough MA
Roger F. Osmond - Littleton MA
Michael J. Fitzgerald - Framingham MA

Assignee:

Storage Technology Corporation - Louisville CO

International Classification:

G06F 15177
G06F 1516

US Classification:

709250

Abstract:

A wiring hub for interconnecting a plurality of network components to form a local area network, the wiring hub including a data signal bus and a programmable switching mechanism connected to the data signal bus. The switching mechanism includes a plurality of ports each of which can be electrically coupled to a different one of the plurality of network components so as to pass communications signals to and receive communications signals from the network component to which it is coupled. The programmable switching mechanism interconnects a selectable set of the plurality of ports together through the data signal bus and in any user selectable ordered sequence.