Michael J Hunter

US Patent:

8001417, Aug 16, 2011

Filed:

Dec 30, 2007

Appl. No.:

11/967248

Inventors:

Richard J. Byrne - Hillsborough NJ, US
Thomas Klucsarits - Northampton PA, US
Nevin C. Heintze - Sunnyvale CA, US
Ambalavanar Arulambalam - Macungie PA, US
Michael J. Hunter - Mertztown PA, US
Xing Zhao - Shanghai, CN
Zhi Ping He - Shanghai, CN
Yun Peng - Shanghai, CN
Qian Gao Xu - Shanghai, CN
Eu Gene Goh - Singapore, SG
Silvester Tjandra - Singapore, SG

Assignee:

Agere Systems Inc. - Allentown PA

International Classification:

G06F 11/00

US Classification:

714 613, 714 51, 714 611

Abstract:

In one embodiment, the invention provides a method for repairing a defective storage device in a physical storage-device array having a plurality of storage devices. The method comprises the steps of identifying a disk error associated with the defective storage device; effecting an error recovery pause based on the disk error; processing one or more outstanding data storage or retrieval requests; and generating a new data storage request instructing the physical disk device array having the defective storage device to store valid data associated with the data storage or retrieval request corresponding to the disk device error, whereby the defective storage device is repaired.

US Patent:

20110091971, Apr 21, 2011

Filed:

Jun 29, 2009

Appl. No.:

12/493741

Inventors:

Janet Davis - Skillman NJ, US
Jiajian Liu - Skillman NJ, US
Gopalan Raghunathan - San Diego CA, US
Michael Joseph Hunter - San Diego CA, US
Jose Pardinas - San Diego CA, US
Judith Ann Connor - San Diego CA, US
Ronald Vernon Swanson - San Diego CA, US
Ellen Chi - San Diego CA, US

International Classification:

C12N 5/0735
C12N 5/071

US Classification:

435377

Abstract:

The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage. The present invention also provides methods to generate and purify agents capable of differentiating pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.

US Patent:

20210163566, Jun 3, 2021

Filed:

Feb 5, 2021

Appl. No.:

17/168503

Inventors:

- Beerse, BE
Raymond J. PATCH - Yardley PA, US
Rui ZHANG - Belle Mead NJ, US
Martin A. CASE - San Diego CA, US
Shamina M. RANGWALA - Furlong PA, US
James N. LEONARD - Ambler PA, US
Raul C. CAMACHO - Philadelphia PA, US
Michael J. HUNTER - Santee CA, US
Katharine E. D'AQUINO - Perkasie PA, US
Wilson EDWARDS - Cardiff-by the-Sea CA, US
Ronald V. SWANSON - Del Mar CA, US
Wenying JIAN - Princeton NJ, US
Yue-Mei ZHANG - Wellesley MA, US
Mark J. WALL - Lansdale PA, US
Ellen CHI - San Diego CA, US

International Classification:

C07K 14/575
A61K 47/68
C07K 16/24
A61K 9/00
A61K 38/17
A61K 38/26
C07K 1/06
C07K 1/107
A61K 47/64
A61P 3/10
A61K 49/00
C07K 1/12
C07K 1/18
C07K 5/02
A61K 47/60
A61P 3/08
A61P 3/00
A61P 3/04
A61P 3/06
A61K 38/22
A61K 45/06
C07K 16/00

Abstract:

The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.

US Patent:

20210094998, Apr 1, 2021

Filed:

Oct 30, 2020

Appl. No.:

17/085128

Inventors:

- Beerse, BE
Raymond J. PATCH - Yardley PA, US
Rui ZHANG - Belle Mead NJ, US
Martin A. CASE - San Diego CA, US
Mark J. WALL - Lansdale PA, US
Yue-Mei ZHANG - Wellesley MA, US
Shamina M. RANGWALA - Furlong PA, US
James N. LEONARD - Ambler PA, US
Raul C. CAMACHO - Philadelphia PA, US
Michael J. HUNTER - Santee CA, US
Katharine E. D'AQUINO - Perkasie PA, US
Wilson EDWARDS - Cardiff-by the-Sea CA, US
Ronald V. SWANSON - Del Mar CA, US
Wenying JIAN - Princeton NJ, US
Ellen CHI - San Diego CA, US

International Classification:

C07K 14/575
A61K 47/68
C07K 16/24
A61K 9/00
A61K 38/17
A61K 38/26
C07K 1/06
C07K 1/107
A61K 47/64
A61P 3/10
A61K 49/00
C07K 1/12
C07K 1/18
C07K 5/02
A61K 47/60
A61P 3/08
A61P 3/00
A61P 3/04
A61P 3/06
A61K 38/22
A61K 45/06
C07K 16/00

Abstract:

The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.

US Patent:

20200385439, Dec 10, 2020

Filed:

Aug 21, 2020

Appl. No.:

16/947875

Inventors:

- Beerse, BE
Raymond J. Patch - Yardley PA, US
Rui Zhang - Belle Mead NJ, US
Martin A. Case - San Diego CA, US
Shamina M. Rangwala - Furlong PA, US
James N. Leonard - Ambler PA, US
Raul C. Camacho - Philadelphia PA, US
Michael J. Hunter - Santee CA, US
Katharine E. D'Aquino - Perkasie PA, US
Wilson Edwards - Cardiff-by the-Sea CA, US
Ronald V. Swanson - Del Mar CA, US
Wenying Jian - Princeton NJ, US
Yue-Mei Zhang - Wellesley MA, US
Mark J. Wall - Lansdale PA, US
Ellen Chi - San Diego CA, US

International Classification:

C07K 14/575
A61K 47/68
C07K 16/24
A61K 9/00
A61K 38/17
A61K 38/26
C07K 1/06
C07K 1/107
A61K 47/64
A61P 3/10
A61K 49/00
C07K 1/12
C07K 1/18
C07K 5/02
A61K 47/60
A61P 3/08
A61P 3/00
A61P 3/04
A61P 3/06
A61K 38/22
A61K 45/06
C07K 16/00

Abstract:

The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.

US Patent:

20200283491, Sep 10, 2020

Filed:

Mar 16, 2020

Appl. No.:

16/820174

Inventors:

- Beerse, BE
Raymond J. PATCH - Yardley PA, US
Rui ZHANG - Belle Mead NJ, US
Martin A. CASE - San Diego CA, US
Shamina M. RANGWALA - Furlong PA, US
James N. LEONARD - Ambler PA, US
Raul C. CAMACHO - Philadelphia PA, US
Michael J. HUNTER - Santee CA, US
Katharine E. D'AQUINO - Perkasie PA, US
Wilson EDWARDS - Cardiff-by the-Sea CA, US
Ronald V. SWANSON - Del Mar CA, US
Wenying JIAN - Princeton NJ, US
Yue-Mei ZHANG - Wellesley MA, US
Mark J. WALL - Lansdale PA, US
Ellen CHI - San Diego CA, US

International Classification:

C07K 14/575
A61K 47/68
C07K 16/24
A61K 9/00
A61K 38/17
A61K 38/26
C07K 1/06
C07K 1/107
A61K 47/64
A61P 3/10
A61K 49/00
C07K 1/12
C07K 1/18
C07K 5/02
A61K 47/60
A61P 3/08
A61P 3/00
A61P 3/04
A61P 3/06
A61K 38/22
A61K 45/06
C07K 16/00

Abstract:

The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.

US Patent:

20190367577, Dec 5, 2019

Filed:

Aug 16, 2019

Appl. No.:

16/542751

Inventors:

- Beerse, BE
Raymond J. PATCH - Yardley PA, US
Rui ZHANG - Belle Mead NJ, US
Martin A. CASE - San Diego CA, US
Shamina M. RANGWALA - Furlong PA, US
James N. LEONARD - Ambler PA, US
Raul C. CAMACHO - Philadelphia PA, US
Michael J. HUNTER - Santee CA, US
Katharine E. D'AQUINO - Perkasie PA, US
Wilson EDWARDS - Cardiff-by the-Sea CA, US
Ronald V. SWANSON - Del Mar CA, US
Wenying JIAN - Princeton NJ, US
Yue-Mei ZHANG - Wellesley MA, US
Mark J. WALL - Lansdale PA, US
Ellen CHI - San Diego CA, US

International Classification:

C07K 14/575
A61K 47/64
A61P 3/10
A61K 38/17
A61K 49/00
C07K 1/12
C07K 1/18
C07K 5/02
A61K 47/60
A61P 3/08
A61P 3/00
A61P 3/04
A61P 3/06
A61K 38/22
A61K 45/06
A61K 47/68
C07K 16/00

Abstract:

The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.

US Patent:

20190298849, Oct 3, 2019

Filed:

Oct 26, 2017

Appl. No.:

16/344174

Inventors:

- Beerse, BE
Raymond J. PATCH - Yardley PA, US
Rui ZHANG - Belle Mead NJ, US
Martin A. CASE - San Diego CA, US
Shamina M. RANGWALA - Furlong PA, US
James N. LEONARD - Ambler PA, US
Raul C. CAMACHO - Philadelphia PA, US
Michael J. HUNTER - Santee CA, US
Katharine E. D'AQUINO - Perkasie PA, US
Wilson EDWARDS - Cardiff-by the-Sea CA, US
Ronald V. SWANSON - Del Mar CA, US
Wenying JIAN - Princeton NJ, US
Yue-Mei ZHANG - Wellesley MA, US
Mark J. WALL - Lansdale PA, US
Ellen CHI - San Diego CA, US

International Classification:

A61K 47/68
A61K 9/00
A61K 38/26
A61K 38/17
A61P 3/04

Abstract:

The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.