Michael Wen Liu

US Patent:

8410133, Apr 2, 2013

Filed:

Jun 2, 2010

Appl. No.:

12/792044

Inventors:

Juan-Miguel Jimenez - Abingdon, GB
Philip Collier - Cambridge MA, US
Jeremy Green - Waltham MA, US
Gregory Henkel - Carlsbad CA, US
Michael Liu - Oceanside CA, US
Timothy Neuberger - San Diego CA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

C07D 513/02
C07D 515/02
A01N 43/42
A61K 31/44

US Classification:

514303, 546119

Abstract:

The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds, the methods of using the aforementioned compounds, and compounds in the treatment of various diseases, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

US Patent:

8518953, Aug 27, 2013

Filed:

Jun 2, 2010

Appl. No.:

12/792050

Inventors:

Albert Pierce - Cambridge MA, US
Jon Come - Cambridge MA, US
John Court - Littleton MA, US
Gregory Henkel - Carlsbad CA, US
Michael Liu - Oceanside CA, US
Timothy Neuberger - San Diego CA, US
Huai Gao - Arlington MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

C07D 471/04
A61K 31/506

US Classification:

514256, 544328

Abstract:

The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

US Patent:

20040030428, Feb 12, 2004

Filed:

May 5, 2003

Appl. No.:

10/429235

Inventors:

Myrick Crampton - Mt. Pleasant SC, US
Michael Liu - Germantown MD, US
Jay Harrison - Mount Airy MD, US

Assignee:

Manugistics, Inc.

International Classification:

G06F019/00

US Classification:

700/101000

Abstract:

The present invention optimizes shop floor operations by generating production schedules that respect the complex manufacturing rules of specified production operations. The invention utilizes attribute-sensitive changeover models that consider both the duration and cost of each changeover. Since the invention considers more than just the item, changeover models can be based at the item level and the item attribute level. The invention includes realistic models that simulate operations for a variety of process and discrete manufacturing work centers and departments. These models support reusable and auxiliary resources, resource groups, user-defined units of measure, detailed bills of material (BOMs), production rate models, and production method models. The sequencing invention can be integrated with other planning optimization systems, including planning and scheduling engines, to provide further shop floor optimization to productively drive the sequencing of a complex business.

US Patent:

20110020376, Jan 27, 2011

Filed:

Jun 2, 2010

Appl. No.:

12/791976

Inventors:

Juan-Miguel Jimenez - Abingdon, GB
Andrew Miller - Upton, GB
Jeremy Green - Waltham MA, US
Huai Gao - Arlington MA, US
Gregory Henkel - Carlsbad CA, US
Michael Liu - Oceanside CA, US
Timothy Neuberger - San Diego CA, US

Assignee:

VERTEX PHARMACEUTICALS INCORPORATED - Cambridge MA

International Classification:

A61K 31/506
C07D 471/04
C07D 403/14
C07D 403/12
C07D 413/14
A61K 31/496
A61K 31/5377
A61K 39/00
A61P 3/10
A61P 19/10
A61P 25/28
A61P 25/16
A61P 25/00
A61P 25/18
A61P 19/02
A61P 7/00
C12N 9/99
C12N 5/02

US Classification:

4241841, 544328, 544295, 544294, 544122, 514256, 51425219, 5142345, 435184, 435375

Abstract:

The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

US Patent:

20130245273, Sep 19, 2013

Filed:

Mar 5, 2013

Appl. No.:

13/785019

Inventors:

Philip Collier - Arlington MA, US
Jeremy Green - Waltham MA, US
Gregory Henkel - Carlsbad CA, US
Michael Liu - Oceanside CA, US
Timothy Neuberger - San Diego CA, US

Assignee:

VERTEX PHARMACEUTICALS INCORPORATED - Cambridge MA

International Classification:

C07D 417/12

US Classification:

5462707

Abstract:

The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

US Patent:

20140364450, Dec 11, 2014

Filed:

Apr 15, 2014

Appl. No.:

14/253054

Inventors:

- Boston MA, US
Philip Collier - Arlington MA, US
Gregory Henkel - Carlsbad CA, US
Michael Liu - Oceanside CA, US
Timothy Neuberger - San Diego CA, US
Jeremy Green - Waltham MA, US

International Classification:

C07D 471/04
A61K 45/06
C07D 417/12
A61K 31/437
A61K 31/4439

US Classification:

514303, 514342, 546119, 5462707, 435184

Abstract:

The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

US Patent:

20140194444, Jul 10, 2014

Filed:

Jan 15, 2014

Appl. No.:

14/155624

Inventors:

- Boston MA, US
Andrew Miller - Upton Didcot, GB
Jeremy Green - Waltham MA, US
Huai Gao - Arlington MA, US
Gregory Henkel - Carlsbad CA, US
Michael Liu - Oceanside CA, US
Timothy Neuberger - San Diego CA, US

International Classification:

C07D 471/04
C07D 405/14

US Classification:

514256, 544328

Abstract:

The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.