Michael Wei Liu

US Patent:

8410133, Apr 2, 2013

Filed:

Jun 2, 2010

Appl. No.:

12/792044

Inventors:

Juan-Miguel Jimenez - Abingdon, GB
Philip Collier - Cambridge MA, US
Jeremy Green - Waltham MA, US
Gregory Henkel - Carlsbad CA, US
Michael Liu - Oceanside CA, US
Timothy Neuberger - San Diego CA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

C07D 513/02
C07D 515/02
A01N 43/42
A61K 31/44

US Classification:

514303, 546119

Abstract:

The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds, the methods of using the aforementioned compounds, and compounds in the treatment of various diseases, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

US Patent:

8518953, Aug 27, 2013

Filed:

Jun 2, 2010

Appl. No.:

12/792050

Inventors:

Albert Pierce - Cambridge MA, US
Jon Come - Cambridge MA, US
John Court - Littleton MA, US
Gregory Henkel - Carlsbad CA, US
Michael Liu - Oceanside CA, US
Timothy Neuberger - San Diego CA, US
Huai Gao - Arlington MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

C07D 471/04
A61K 31/506

US Classification:

514256, 544328

Abstract:

The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

US Patent:

20110020376, Jan 27, 2011

Filed:

Jun 2, 2010

Appl. No.:

12/791976

Inventors:

Juan-Miguel Jimenez - Abingdon, GB
Andrew Miller - Upton, GB
Jeremy Green - Waltham MA, US
Huai Gao - Arlington MA, US
Gregory Henkel - Carlsbad CA, US
Michael Liu - Oceanside CA, US
Timothy Neuberger - San Diego CA, US

Assignee:

VERTEX PHARMACEUTICALS INCORPORATED - Cambridge MA

International Classification:

A61K 31/506
C07D 471/04
C07D 403/14
C07D 403/12
C07D 413/14
A61K 31/496
A61K 31/5377
A61K 39/00
A61P 3/10
A61P 19/10
A61P 25/28
A61P 25/16
A61P 25/00
A61P 25/18
A61P 19/02
A61P 7/00
C12N 9/99
C12N 5/02

US Classification:

4241841, 544328, 544295, 544294, 544122, 514256, 51425219, 5142345, 435184, 435375

Abstract:

The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

US Patent:

20110224197, Sep 15, 2011

Filed:

Sep 9, 2010

Appl. No.:

12/878246

Inventors:

Gregory William Henkel - Carlsbad CA, US
Michael Liu - Oceanside CA, US
Timothy Neuberger - San Diego CA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

A61K 31/541
A61K 31/517
A61K 31/506
A61K 31/5377
A61K 31/496
A61K 31/4439
A61K 31/444
C12N 9/99
C12Q 1/48
C07D 471/04
C07D 417/14
C07D 495/04
C07D 403/12
A61P 25/00
A61P 25/28
A61P 25/16
A61P 19/10
A61P 7/00
A61P 3/10
A61P 19/02
A61P 25/18
A61P 9/00

US Classification:

5142282, 5142581, 514256, 51426623, 5142345, 51425219, 514342, 514303, 435184, 435 15, 544279, 544 62, 544278, 544328, 544295

Abstract:

The present invention relates to compounds useful as inhibitors of protein kinases, such as inhibitors of GSK-3. The invention provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. The invention provides processes for preparing compounds of the invention. The invention provides methods of identifying compounds useful for treatment of diabetes, diabetic neuropathy, osteoporosis, Alzheimer's disease, Huntington's disease, Parkinson's disease, AIDS-associated dementia, bipolar disorder, amyotrophic lateral sclerosis, multiple sclerosis, schizophrenia, leukocytopenia, cardiomyocyte hypertrophy, stroke, post-stroke, spinal cord injury, traumatic brain injury, Charcot-Marie-Tooth, peripheral nerve regeneration, and rheumatoid arthritis.

US Patent:

20130245273, Sep 19, 2013

Filed:

Mar 5, 2013

Appl. No.:

13/785019

Inventors:

Philip Collier - Arlington MA, US
Jeremy Green - Waltham MA, US
Gregory Henkel - Carlsbad CA, US
Michael Liu - Oceanside CA, US
Timothy Neuberger - San Diego CA, US

Assignee:

VERTEX PHARMACEUTICALS INCORPORATED - Cambridge MA

International Classification:

C07D 417/12

US Classification:

5462707

Abstract:

The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

US Patent:

20140364450, Dec 11, 2014

Filed:

Apr 15, 2014

Appl. No.:

14/253054

Inventors:

- Boston MA, US
Philip Collier - Arlington MA, US
Gregory Henkel - Carlsbad CA, US
Michael Liu - Oceanside CA, US
Timothy Neuberger - San Diego CA, US
Jeremy Green - Waltham MA, US

International Classification:

C07D 471/04
A61K 45/06
C07D 417/12
A61K 31/437
A61K 31/4439

US Classification:

514303, 514342, 546119, 5462707, 435184

Abstract:

The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

US Patent:

20140194444, Jul 10, 2014

Filed:

Jan 15, 2014

Appl. No.:

14/155624

Inventors:

- Boston MA, US
Andrew Miller - Upton Didcot, GB
Jeremy Green - Waltham MA, US
Huai Gao - Arlington MA, US
Gregory Henkel - Carlsbad CA, US
Michael Liu - Oceanside CA, US
Timothy Neuberger - San Diego CA, US

International Classification:

C07D 471/04
C07D 405/14

US Classification:

514256, 544328

Abstract:

The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.