Michael Roy Mclaughlin

US Patent:

8620749, Dec 31, 2013

Filed:

Jun 20, 2011

Appl. No.:

13/164385

Inventors:

Simon Rothman - Palo Alto CA, US
Michael McLaughlin - Menlo Park CA, US

Assignee:

Glyde Corporation - Palo Alto CA

International Classification:

G06Q 30/00

US Classification:

705 1453

Abstract:

Systems, apparatuses, and methods are provided for facilitating electronic commerce via a web banner. Entire purchase transactions may be provided via the web banner, where an end user purchases products sold from third parties via the web banner. Entire sale listing transactions may also be provided via the web banner, where an end user lists products for sale via the web banner. Further, users may be identified when they access third party web sites, and customized offers may be generated and communicated to the identified users.

US Patent:

20120323732, Dec 20, 2012

Filed:

Jun 20, 2011

Appl. No.:

13/164353

Inventors:

Simon Rothman - Palo Alto CA, US
Michael McLaughlin - Menlo Park CA, US

Assignee:

Glyde Corporation - Palo Alto CA

International Classification:

G06Q 30/00

US Classification:

705 2641, 705 272

Abstract:

Systems, apparatuses, and methods are provided for facilitating electronic commerce via a web banner. Entire purchase transactions may be provided via the web banner, where an end user purchases products sold from third parties via the web banner. Entire sale listing transactions may also be provided via the web banner, where an end user lists products for sale via the web banner. Further, users may be identified when they access third party web sites, and customized offers may be generated and communicated to the identified users.

US Patent:

20220214335, Jul 7, 2022

Filed:

Feb 9, 2022

Appl. No.:

17/650443

Inventors:

- Pleasanton CA, US
Niandong LIU - San Ramon CA, US
Bart Lee STAKER - Poulsbo WA, US
Michael David MCLAUGHLIN - San Jose CA, US

International Classification:

G01N 33/536
C12Q 1/6825
G01N 21/64
G01N 1/30
H03M 13/15
G16B 40/00

Abstract:

Methods are provided for detecting a single compound analyte immobilized to a solid substrate by serially contacting and removing different probes to the same analyte.

US Patent:

20220206006, Jun 30, 2022

Filed:

Mar 16, 2022

Appl. No.:

17/696631

Inventors:

- Pleasanton CA, US
Niandong LIU - San Ramon CA, US
Bart Lee STAKER - Poulsbo WA, US
Michael David MCLAUGHLIN - San Jose CA, US

International Classification:

G01N 33/58
G01N 27/414
C12Q 1/6837
C12Q 1/6825
C12Q 1/6804

Abstract:

Electrical detection methods are used to identify and further characterize single-molecule target analytes such as proteins and nucleic acids. A composition including a probe region and a tail region is contacted with a target analyte. The probe region specifically binds to the target analyte. The tail region is coupled to the probe region, and includes a nucleic acid template for polynucleotide synthesis. When conditions are such that polynucleotide synthesis occurs along the tail region, one hydrogen ion is released for every nucleotide that is incorporated into the tail region. A transistor such as an ISFET detects and measures changes in ion concentration, and these measurements can be used to identify the tail region and thus characterize the corresponding target analyte.

US Patent:

20210325397, Oct 21, 2021

Filed:

Feb 17, 2021

Appl. No.:

17/178203

Inventors:

- Pleasanton CA, US
Niandong LIU - San Ramon CA, US
Bart Lee STAKER - Poulsbo WA, US
Michael David MCLAUGHLIN - San Jose CA, US

International Classification:

G01N 33/58
G01N 27/414
C12Q 1/6837
C12Q 1/6825
C12Q 1/6804

Abstract:

Electrical detection methods are used to identify and further characterize single-molecule target analytes such as proteins and nucleic acids. A composition including a probe region and a tail region is contacted with a target analyte. The probe region specifically binds to the target analyte. The tail region is coupled to the probe region, and includes a nucleic acid template for polynucleotide synthesis. When conditions are such that polynucleotide synthesis occurs along the tail region, one hydrogen ion is released for every nucleotide that is incorporated into the tail region. A transistor such as an ISFET detects and measures changes in ion concentration, and these measurements can be used to identify the tail region and thus characterize the corresponding target analyte.

US Patent:

20210087626, Mar 25, 2021

Filed:

Oct 1, 2020

Appl. No.:

17/061023

Inventors:

- Pleasanton CA, US
Niandong LIU - San Ramon CA, US
Michael David MCLAUGHLIN - San Jose CA, US
Bart Lee STAKER - Poulsbo WA, US

International Classification:

C12Q 1/6874
G16B 30/00
G16B 25/30
G06K 9/00
G06T 7/73

Abstract:

Disclosed herein are methods and systems for detection and discrimination of optical signals from a densely packed substrate. These have broad applications for biomolecule detection near or below the diffraction limit of optical systems, including in improving the efficiency and accuracy of polynucleotide sequencing applications.

US Patent:

20210072233, Mar 11, 2021

Filed:

Dec 26, 2019

Appl. No.:

16/727732

Inventors:

- Pleasanton CA, US
Niandong LIU - San Ramon CA, US
Bart Lee STAKER - Poulsbo WA, US
Michael David MCLAUGHLIN - San Jose CA, US

International Classification:

G01N 33/536
H03M 13/15
G01N 1/30
G01N 21/64
C12Q 1/6825
G16B 40/00

Abstract:

Methods and systems are provided for small molecule analyte detection using digital signals, key encryption, and communications protocols. The methods provide detection of a large numbers of proteins, peptides, RNA molecules, and DNA molecules in a single optical or electrical detection assay within a large dynamic range.

US Patent:

20170032428, Feb 2, 2017

Filed:

Jul 31, 2015

Appl. No.:

14/815791

Inventors:

- Scottsdale AZ, US
Michael McLaughlin - Menlo Park CA, US
Greg Hollingsworth - Cedar Rapids IA, US

International Classification:

G06Q 30/02
G06F 17/30

Abstract:

A registrant may register a domain name with a registrar. A domain name industry may be determined based on one or more keywords parsed from the domain name. A hosting provider may host a website (which is preferably a parked page) pointed to by the domain name. Advertisers may provide advertisements that are suitable to be displayed on a website and a corresponding advertisement geo-location and an advertisement industry for each advertisement. The hosting provider may receive the website visitor at the website and determine a visitor geo-location. The website visitor may enter a search query in a search field on the website and determine a search query industry based on parsed keywords from the search query. The hosting provider may select one or more advertisements to display to the visitor on the website by 1) comparing the domain name industry to the advertisement industries, 2) comparing the search query industry to the advertisement industries and/or 3) comparing the visitor geo-location to the advertisement geo-locations. In this manner, advertisements may be selected that most closely match the website visitor in location and industry. The hosting provider may then display the website, with the selected advertisements, to the website visitor.