Min Matthew Lu

age ~51

from Newton, MA

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Also known as:

Lu Min

Connected to:

Min Lu Phones & Addresses

Newton, MA
76 Boylston St APT 3, Chestnut Hill, MA 02467
San Diego, CA
180 Big Springs Rd, Riverside, CA 92507
Del Mar, CA
Newton Hlds, MA

Work

Company:

Ucsd
2008
Position:

Direct supervisor

Education

School / High School:

University of California- San Diego, CA
2010
Specialities:

Project Scientist in Endocrinology and Metabolism

Skills

REVIEW EXPERIENCE: Invited reviewer for ... • retro-orbital • saphenous vein • cardiac puncture Immunohistochemistry Pr... • hepatocyte • and macrophage isolation Drug dosing: subQ • IV • IP and oral gavage Dietary manipulation:... • high cholesterol feeding • caloric restriction Insulin tolerance test • glucose tolerance test • and pyruvate tolerance test Leptin sensi... • Dual-emission X-ray absorptiometry • and rodent MRI Bone barrow transplantati... • NAD+ • lactate • pyruvate • glycerol • FFA • TG etc) MOLECULAR BIOLOGY TECHNIQUES: L... • Northern Blotting • and Western Blotting PCR and qPCR DNA su... • purification and infection Immunostainin... • macrophage • myocyte • and neuronal cell differentiation Glucos...

Us Patents

Core Structure Of Gp41 From The Hiv Envelope Glycoprotein
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US Patent:

6506554, Jan 14, 2003
Filed:

Jan 18, 2000
Appl. No.:

09/484925
Inventors:

David C. Chan - Brookline MA
Deborah Fass - Cambridge MA
Min Lu - New York NY
James M. Berger - Cambridge MA
Peter S. Kim - Lexington MA
Assignee:

Whitehead Institute for Biomedical Research - Cambridge MA
International Classification:

C12Q 170
US Classification:

435 5, 435236, 530350, 436501, 436 86
Abstract:

Described are the crystal structure of the -helical domain of the gp41 component of HIV-1 envelope glycoprotein which represents the core of fusion-active gp41, methods of identifying and designing drugs which inhibit gp41 function and drugs which do so.

Polynucleotide Sequences From Rice
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US Patent:

6544783, Apr 8, 2003
Filed:

Apr 26, 2001
Appl. No.:

09/843472
Inventors:

J. Ranjan Perera - Carlsbad CA 92009
Min Lu - San Diego CA 92129
Animesh Ray - San Diego CA 92130
International Classification:

C12N 1563
US Classification:

4353201, 536 231, 536 241
Abstract:

The present invention provides polynucleotides isolated from eucaryotic organisms which are structural genes or promoters. Such isolated polynucleotides are particularly useful in the modification of gene expression in plants. This invention also relates to compositions isolated from plants and their use in the modification of gene activation and/or expression. In a specific embodiment, the subject invention provides plant polynucleotide sequences enconding promoters that are components of the cellular activation and transcription apparatus and the use of such polynucleotide sequences in the modification of expression of genes.

Polynucleotide Sequences From Rice
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US Patent:

7232940, Jun 19, 2007
Filed:

Mar 17, 2003
Appl. No.:

10/356820
Inventors:

J. Ranjan Perera - Carlsbad CA, US
Min Lu - San Diego CA, US
Animesh Ray - San Diego CA, US
Assignee:

Missouri Board of Curators - Columbia MO
International Classification:

C07H 21/04
C12N 15/11
C12N 5/04
C12N 15/82
C12P 21/00
A01H 1/00
US Classification:

800287, 4353201, 435 691, 435419, 435468, 536 241
Abstract:

The present invention provides polynucleotides isolated from eucaryotic organisms which are structural genes or promoters. Such isolated polynucleotides are particularly useful in the modification of gene expression in plants. This invention also relates to compositions isolated from plants and their use in the modification of gene activation and/or expression. In a specific embodiment, the subject invention provides plant polynucleotide sequences encoding promoters that are components of the cellular activation and transcription apparatus and the use of such polynucleotide sequences in the modification of expression of genes.

Core Structure Of Gp41 From The Hiv Envelope Glycoprotein
view source
US Patent:

7402396, Jul 22, 2008
Filed:

Oct 7, 2003
Appl. No.:

10/680853
Inventors:

David C. Chan - Brookline MA, US
Deborah Fass - Cambridge MA, US
Min Lu - New York NY, US
James M. Berger - Cambridge MA, US
Peter S. Kim - Lexington MA, US
Assignee:

Whitehead Institute for Biomedical Research - Cambridge MA
International Classification:

G01N 33/53
US Classification:

435 71, 435 5
Abstract:

Described are the crystal structure of the α-helical domain of the gp41 component of HIV-1 envelope glycoprotein which represents the core of fusion-active gp41, methods of identifying and designing drugs which inhibit gp41 function and drugs which do so.

Rationale, Methods, And Assays For Identifying Human And Non-Human Primate Taste Specific Genes And Use Thereof In Taste Modulator And Therapeutic Screening Assays
view source
US Patent:

7932058, Apr 26, 2011
Filed:

Jun 6, 2008
Appl. No.:

12/134302
Inventors:

Bryan Moyer - San Diego CA, US
Albert Zlotnik - San Diego CA, US
Peter Hevezi - Encinitas CA, US
Hortensia Soto - San Diego CA, US
Dalia Kalabat - El Cajon CA, US
Min Lu - San Diego CA, US
Na Gao - San Diego CA, US
Evan Carl White - Fair Oaks CA, US
Assignee:

Senomyx, Inc. - San Diego CA
International Classification:

C12N 15/10
C07K 14/705
US Classification:

435 911, 435 78
Abstract:

This invention relates to novel rationale and methods for identifying human and primate taste-specific genes, including genes involved in salty taste perception, especially human salty taste perception, but also genes involved in sweet, bitter, umami, and sour taste perception, and genes involved in other taste cell or taste receptor related activities such as digestive function and digestive related diseases, taste cell turnover, immunoregulation of the oral and digestive tract, and metabolic regulation such as in diabetes and obesity, the genes identified using these methods, and assays for identifying taste modulators (enhancers or blockers) and potential therapeutics using these genes. These compounds have potential application in modulating (enhancing or blocking) taste perception, especially salty taste perception and as potential therapeutics. In addition, this invention relates to novel methods for identifying taste-specific genes that can be used as markers for different taste cell types, including sweet, bitter, umami, sour, salty, and other taste cells in mammals as well as assays that measure the activity of the sweet, bitter, umami, or sour receptor in the presence of these genes to identify modulators of sweet, bitter, umami, and sour taste and to identify therapeutics especially for treating digestive or metabolic disorders, taste loss, and oral infections. Particularly, the genes identified herein and antibodies or oligos thereto can be used as markers to identify and/or purify specific taste cells e. g.

Core Structure Of Gp41 From The Hiv Envelope Glycoprotein
view source
US Patent:

20030099935, May 29, 2003
Filed:

Jul 18, 2002
Appl. No.:

10/200007
Inventors:

David Chan - Brookline MA, US
Deborah Fass - Cambridge MA, US
Min Lu - New York NY, US
James Berger - Cambridge MA, US
Peter Kim - Lexington MA, US
Assignee:

Whitehead Institute for Biomedical Research - Cambridge MA
International Classification:

C12Q001/70
US Classification:

435/005000
Abstract:

Described are the crystal structure of the -helical domain of the gp41 component of HIV-1 envelope glycoprotein which represents the core of fusion-active gp41, methods of identifying and designing drugs which inhibit gp41 function and drugs which do so.

Novel Splice Variants Of Human Epithelial Sodium Channel Genes Expressed In Human Taste Tissue And Uses Thereof
view source
US Patent:

20060223117, Oct 5, 2006
Filed:

Feb 2, 2006
Appl. No.:

11/345403
Inventors:

Bryan Moyer - San Diego CA, US
Fernando Echeverri - Chula Vista CA, US
Min Lu - San Diego CA, US
Bianca Laita - Oceanside CA, US
Assignee:

SENOMYX, INC. - LaJolla CA
International Classification:

G01N 33/53
C07H 21/04
C07K 14/705
C07K 16/28
C12P 21/06
US Classification:

435007100, 530350000, 530388220, 435320100, 435325000, 536023500, 435069100
Abstract:

Nucleic acid sequences encoding novel splice variants that encode subunits of an ENaC expressed in human taste tissue are provided. These splice variants when expressed in association with other ENaC subunits, i.e., α, β and γ subunits or α, β and Δ subunits may be used to produce amiloride-insensitive ENACs. The resultant amiloride-insensitive ENaCs are useful in in vitro assays for identifying ENaC modulators that modulate taste (enhance or inhibit), particularly human salty taste.

Optimized Trpm8 Nucleic Acid Sequences And Their Use In Cell Based Assays And Test Kits To Identify Trpm8 Modulators
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US Patent:

20070259354, Nov 8, 2007
Filed:

Sep 28, 2006
Appl. No.:

11/536394
Inventors:

Guy Servant - San Diego CA, US
Paul Brust - San Diego CA, US
Bryan Moyer - San Diego CA, US
Min Lu - San Diego CA, US
Fernando Echeverri - Chula Vista CA, US
David Dahan - Oceanside CA, US
Mark Zoller - La Jolla CA, US
Mark Williams - Carlsbad CA, US
Rachel Kimmich - Carlsbad CA, US
Poonit Kamdar - San Diego CA, US
Tanya Ditschun - San Diego CA, US
Andrew Patron - San Marcos CA, US
Assignee:

Senomyx, Inc. - San Diego CA
International Classification:

C12Q 1/68
C07H 21/02
C07H 21/04
C12N 15/85
C12N 5/10
US Classification:

435006000, 435320100, 435358000, 435363000, 435365000, 435366000, 435367000, 536023100, 536024100
Abstract:

Modified human TRPM8 nucleic acid sequences which are efficiently expressed in human cells and cell-based assays and test kits containing same are provided. These assays identify TRPM8 modulators using cells that express a modified human TRPM8 nucleic acid sequence according to the invention, wherein said sequence has been modified relative to a wild-type human TRPM8 nucleic acid sequence in order to optimize ion channel expression in desired cells. Assays using these modified TRPM8 sequences have been shown to identify compounds that modulate the human TRPM8 ion channel better or comparably to known coolants such as menthol and icilin.

Name / Title

Company / Classification

Phones & Addresses

Min Lu
Owner

Impressa
Second Hand Stores

530 Craigflower Road, Victoria, BC V9A 2V9
2502940406

Min Lu
Owner

Impressa
Second Hand Stores

2502940406

MIN Lu
COO

Realty Benefit

8794 19 St, Rancho Cucamonga, CA 91701
9494617900

Min J. Lu
Principal

Clw Restaurant, Inc
Eating Place

31 Howard St, Milford, MA 01757

Resumes

Min Lu La Jolla, CA

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Work:

UCSD

2008 to 2000
Direct supervisor UCSD

2008 to 2000
In vivo research manager University of California, Riverside
Riverside, CA
2000 to 2001
Teaching assistant at UC Department of General Surgery, Shanghai Jing-An District Central Hospital

Jul 1997 to Jul 1999
Residency 6th People's Hospital

Jul 1995 to Jul 1997
Internship

Education:

University of California
San Diego, CA
2010 to 2012
Project Scientist in Endocrinology and Metabolism University of California
San Diego, CA
2005 to 2010
Post-doctoral fellow in Endocrinology and Metabolism University of California
Riverside, CA
Sep 1999 to Apr 2005
Ph.D. in Division of Biomedical Sciences Shanghai Second Medical University
Sep 1992 to Jul 1997
M.D. in Department of Clinical Medicine

Skills:

REVIEW EXPERIENCE: Invited reviewer for Diabetes and Endocrinology IN VIVO TECHNIQUES: Transgene and gene-targeting vector construction Mouse embryonic stem cell screening Breeding and handling Tissue harvesting and sectioning Blood collection: tail, retro-orbital, saphenous vein, cardiac puncture Immunohistochemistry Primary adipocyte, hepatocyte, and macrophage isolation Drug dosing: subQ, IV, IP and oral gavage Dietary manipulation: high fat feeding, high cholesterol feeding, caloric restriction Insulin tolerance test, glucose tolerance test, and pyruvate tolerance test Leptin sensitivity test Hyperinsulinemic euglycemic clamp in mice and rats Hyperglycemic and hypoglycemic step clamp in mice and rats Metabolic cage, Dual-emission X-ray absorptiometry, and rodent MRI Bone barrow transplantation En face staining for aortic atherosclerotic plaques Vaginal lavage for mouse estrous cycle Metabolite measurement (ATP, NAD+, lactate, pyruvate, glycerol, FFA, TG etc) MOLECULAR BIOLOGY TECHNIQUES: Luciferase reporter assay and compound screening Southern Blotting, Northern Blotting, and Western Blotting PCR and qPCR DNA subcloning and site-directed mutagenesis Recombinant protein expression and purification FPLC GST pull-down assay In vitro kinase assay EMSA and ChIP assay siRNA design and construction ELISA Immunoprecipitation and co-IP CELL BIOLOGY TECHNIQUES: Mammalian cell culture Adenovirus construction, purification and infection Immunostaining and Oil Red O staining Cytosol and nuclear fractionation Stable and transient transfection Adipocyte, macrophage, myocyte, and neuronal cell differentiation Glucose uptake assay In vitro hemodynamic flow chamber Chemotaxis and cell migration bioassay Deconvolution and confocal microscopy

Medicine Doctors

Min J. Lu

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Specialties:

Hematology/Oncology

Work:

USC Norris Comprehensive Cancer Center
1441 Eastlake Ave, Los Angeles, CA 90089
3238653900 (phone), 3238650061 (fax)

Education:

Medical School
Beijing Med Univ, Beijing City, Beijing, China
Graduated: 1995

Languages:

Chinese
English
Spanish

Description:

Dr. Lu graduated from the Beijing Med Univ, Beijing City, Beijing, China in 1995. She works in Los Angeles, CA and specializes in Hematology/Oncology. Dr. Lu is affiliated with Keck Medical Center Of USC and LAC USC Medical Center.