Min Lu

US Patent:

6506554, Jan 14, 2003

Filed:

Jan 18, 2000

Appl. No.:

09/484925

Inventors:

David C. Chan - Brookline MA
Deborah Fass - Cambridge MA
Min Lu - New York NY
James M. Berger - Cambridge MA
Peter S. Kim - Lexington MA

Assignee:

Whitehead Institute for Biomedical Research - Cambridge MA

International Classification:

C12Q 170

US Classification:

435 5, 435236, 530350, 436501, 436 86

Abstract:

Described are the crystal structure of the -helical domain of the gp41 component of HIV-1 envelope glycoprotein which represents the core of fusion-active gp41, methods of identifying and designing drugs which inhibit gp41 function and drugs which do so.

US Patent:

7179468, Feb 20, 2007

Filed:

Jun 8, 2001

Appl. No.:

09/877606

Inventors:

Min Lu - New York NY, US
Hong Ji - New York NY, US

Assignee:

Cornell Research Foundation, Inc. - Ithaca NY

International Classification:

A61K 39/21

US Classification:

4241881, 4241921, 4242081, 530300, 530350

Abstract:

The present invention provides polypeptides comprising a stabilized trimer of the carboxyl-terminal core region of the ectodomain of an enveloped virus, such as HIV. A subject polypeptide comprises three monomers that form a trimeric coiled coil in a prefusogenic conformation of an enveloped virus such as HIV. The subject polypeptides are useful as vacciness against enveloped virus, such as HIV, which vaccines are also provided. The present invention also provides methods of vaccinating an individual to prevent or treat HIV infection or prevent or treat infection by another enveloped virus, using a subject vaccine. Antibodies or binding portions thereof raised against a C-terminus trimeric coiled coil motif of an HIV gp41 ectodomain, or carboxyl-terminal core region of the ectodomain of another enveloped virus, are also provided as are methods of making such antibodies. Methods for detecting HIV or other enveloped viruses in a sample, as well as methods of screening for drugs which can inhibit HIV infection or other enveloped virus infection, are also provided by the present invention.

US Patent:

7402396, Jul 22, 2008

Filed:

Oct 7, 2003

Appl. No.:

10/680853

Inventors:

David C. Chan - Brookline MA, US
Deborah Fass - Cambridge MA, US
Min Lu - New York NY, US
James M. Berger - Cambridge MA, US
Peter S. Kim - Lexington MA, US

Assignee:

Whitehead Institute for Biomedical Research - Cambridge MA

International Classification:

G01N 33/53

US Classification:

435 71, 435 5

Abstract:

Described are the crystal structure of the α-helical domain of the gp41 component of HIV-1 envelope glycoprotein which represents the core of fusion-active gp41, methods of identifying and designing drugs which inhibit gp41 function and drugs which do so.

US Patent:

8532700, Sep 10, 2013

Filed:

Dec 1, 2009

Appl. No.:

12/628407

Inventors:

Stephanie P. Parlamas - Colts Neck NJ, US
Christina I. Cacioppo - Freehold NJ, US
Min Lu - Freehold NJ, US

Assignee:

AT&T Intellectual Property I, L.P. - Atlanta GA

International Classification:

H04M 1/00
H04B 1/38

US Classification:

4555521, 455557

Abstract:

A method and apparatus for initiating a call are disclosed. For example, the method receives via a tri-mode mobile endpoint device a request for initiating a call and a selection of an access mode from a user, wherein the tri-mode mobile endpoint device is capable of operating in a cellular mode, a Wi-Fi mode, and a wire-based mode for initiating the call. The method then provides the call using the selection of the access mode.

US Patent:

8533340, Sep 10, 2013

Filed:

Apr 11, 2007

Appl. No.:

11/786568

Inventors:

Mark Ratcliffe - Oakhurst NJ, US
Gerald L. Hoover - Middletown Township NJ, US
Min Lu - Freehold NJ, US

Assignee:

AT&T Intellectual Property I, L.P. - Atlanta GA

International Classification:

G06F 15/16

US Classification:

709227, 709223

Abstract:

Systems and methods provide virtual CSCFs in an IMS system. The Virtual CSCFs may be virtual S-CSCFs or virtual P-CSCFs. A master virtual CSCF may be used to distribute subscriber data and initial filter criteria to the virtual CSCFs in a group. Thus one of multiple servers may be used for processing call sessions for the same subscriber, thereby avoiding overloading a particular CSCF in an IMS system.

US Patent:

8583102, Nov 12, 2013

Filed:

Nov 30, 2012

Appl. No.:

13/691671

Inventors:

Min Lu - Holmdel NJ, US
Stephanie Parlamas - Colts Neck NJ, US

Assignee:

AT&T Intellectual Property II, L.P. - Atlanta GA

International Classification:

H04W 4/00

US Classification:

4554221, 4554144, 455522, 4554521, 455423, 455461, 455 69, 455 67

Abstract:

A method for determining an amount of time required to download a data file to a wireless device includes receiving information indicating a first amount of wireless bandwidth allocated for the download of the data file, calculating a first length of time required to download the data file to the wireless device based on the first amount of wireless bandwidth allocated, and comparing the first length of time required to a predetermined amount of time. If the first length of time required is less than the predetermined amount of time, the download begins. If the first length of time required is more than the predetermined amount of time, information indicating the first length of time required is sent to the wireless device, a start download signal is received from the wireless device, and download of the data file to the wireless device begins in response to the start download signal.

US Patent:

20030099935, May 29, 2003

Filed:

Jul 18, 2002

Appl. No.:

10/200007

Inventors:

David Chan - Brookline MA, US
Deborah Fass - Cambridge MA, US
Min Lu - New York NY, US
James Berger - Cambridge MA, US
Peter Kim - Lexington MA, US

Assignee:

Whitehead Institute for Biomedical Research - Cambridge MA

International Classification:

C12Q001/70

US Classification:

435/005000

Abstract:

Described are the crystal structure of the -helical domain of the gp41 component of HIV-1 envelope glycoprotein which represents the core of fusion-active gp41, methods of identifying and designing drugs which inhibit gp41 function and drugs which do so.

US Patent:

20050089526, Apr 28, 2005

Filed:

Sep 6, 2002

Appl. No.:

10/489040

Inventors:

John Moore - New York NY, US
James Binley - San Diego CA, US
Min Lu - New York NY, US
William Olson - New York NY, US
Norbert Schulke - New City NY, US
Jason Gardner - Ardsley NY, US
Paul Maddon - Scarsdale NY, US
Rogier Sanders - Amsterdam, NL

International Classification:

A61K039/21
C07K014/16

US Classification:

424188100, 530395000

Abstract:

This invention provides stable HIV-1 pre-fusion envelope glycoprotein trimeric complexes. This invention also provides related polypeptides and compositions comprising pharmaceutically acceptable particles and the trimeric complexes operably affixed thereto. This invention further provides related nucleic acids, vectors, host cells, compositions, production methods, and prophylactic and therapeutic methods.