Miroslav Petro

US Patent:

6345528, Feb 12, 2002

Filed:

May 24, 2001

Appl. No.:

09/866428

Inventors:

Miroslav Petro - Sunnyvale CA
Adam Safir - Oakland CA
Ralph B. Nielsen - San Jose CA
Eric D. Carlson - Palo Alto CA

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

G01N 3030

US Classification:

73 6152, 73 6157, 73 6156, 422 70, 210663, 95 87

Abstract:

Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.

US Patent:

6436292, Aug 20, 2002

Filed:

Sep 26, 2000

Appl. No.:

09/670503

Inventors:

Miroslav Petro - Sunnyvale CA

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

B01D 1508

US Classification:

210656, 210659, 210143, 2101982, 73 6152, 436161, 422 70

Abstract:

High-performance liquid chromatography (HPLC) methods and systems are disclosed that combine parallel chromatographic separation of a plurality of samples with a detection technique that involves post-separation treatment of the plurality of samples to enhance one or more properties of the sample or of a component thereof, followed by detection of the one or more enhanced properties. Selective, tunable detection schemes are achievable, and are particularly advantageous as applied in connection with combinatorial chemistry, combinatorial material science and more particularly, combinatorial synthesis and screening of polymeric materials.

US Patent:

6491816, Dec 10, 2002

Filed:

Sep 18, 2001

Appl. No.:

09/956199

Inventors:

Miroslav Petro - Santa Clara CA

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

B01D 1508

US Classification:

2101982, 210143, 210656, 210659, 73 6152, 422 70

Abstract:

High-performance liquid chromatography (HPLC) methods and systems are disclosed that combine sequential, serial injection of a plurality of samples into mobile-phases supplied in parallel to two or more chromatographic columns, such that staggered, parallel separation of the plurality of samples is effected. Because injection of samples is relatively fast as compared to separation, substantial efficiencies are gained with respect to overall sample throughput. The disclosed HPLC methods and systems are preferably applied in connection with combinatorial chemistry, combinatorial material science and more particularly, combinatorial synthesis and screening of polymeric materials.

US Patent:

6492184, Dec 10, 2002

Filed:

Jun 21, 2001

Appl. No.:

09/886331

Inventors:

Miroslav Petro - Sunnyvale CA
Adam Safir - Oakland CA
Ralph B. Nielsen - San Jose CA
Thomas S. Lee - Palo Alto CA

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

G01N 110

US Classification:

436180, 436179, 436 43, 436 50

Abstract:

Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.

US Patent:

6577392, Jun 10, 2003

Filed:

Nov 28, 2000

Appl. No.:

09/728374

Inventors:

Ralph B. Nielsen - San Jose CA
Sigrid C. Kuebler - Sunnyvale CA
Thomas S. Lee - Los Gatos CA
Adam Safir - Berkeley CA
Miroslav Petro - San Jose CA

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

G01N 2100

US Classification:

356338, 356337

Abstract:

Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.

US Patent:

6584832, Jul 1, 2003

Filed:

Feb 11, 2002

Appl. No.:

10/073687

Inventors:

Miroslav Petro - Sunnyvale CA
Adam Safir - Oakland CA
Ralph B. Nielsen - San Jose CA
G. Cameron Dales - Palo Alto CA
Eric D. Carlson - Palo Alto CA
Thomas S. Lee - Palo Alto CA

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

B01D 1508

US Classification:

73 6152, 73 6155, 7386472, 73 5404, 73 6456, 73 6141, 422 681, 422 70, 210659, 210181, 210DIG 13, 210 96

Abstract:

Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed, where the polymer sample, solvent, liquid chromatograph column and/or mobile phase eluant is heated to temperatures of at least 75 degrees Celsius during the sample injection or elution process. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.

US Patent:

6632404, Oct 14, 2003

Filed:

Aug 2, 2000

Appl. No.:

09/631442

Inventors:

J. Christopher Freitag - Santa Clara CA
Miroslav Petro - San Jose CA

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

B01L 1100

US Classification:

422103, 7386372, 7386373, 137247, 13724713, 422 88, 422 89, 422 90, 422 91, 422 92, 422 93, 422 70

Abstract:

A sample injector valve capable of introducing multiple samples of material into multiple liquid or gas streams is provided. Such a valve is particularly useful for injecting multiple samples under pressure into a combinatorial chemistry system with moving streams of fluid, such as a parallel pressure reactor or a rapid flow analysis system using multi-channel or parallel chromatography and related techniques. The valve is further capable of functioning on a small scale with automatic sampling equipment.

US Patent:

6716948, Apr 6, 2004

Filed:

Jul 31, 2000

Appl. No.:

09/630328

Inventors:

Gerrit Klaerner - Campbell CA
Miroslav Petro - San Jose CA
Dominique Charmot - Los Gatos CA
Didier Benoit - San Jose CA

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

C08F12054

US Classification:

5263031, 526209, 526210, 526217, 526222, 526236, 524555

Abstract:

Controlled architecture polymers made preferably with acrylamide type monomers are prepared in living-type or semi-living-type free radical polymerizations, with the architecture preferably being other than linear, such as star, branched, grafted or hyper-branched. The controlled architecture polymers have high weight average molecular weights and low viscosities, which make they particularly useful in replaceable capillary electrophoresis separation media for biological molecules, such as DNA fragments.