Mustapha Soukri from Raleigh, NC, age 54

Director, Materials Chemistry

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Location:

Raleigh, NC

Industry:

Non-Profit Organization Management

Work:

Rti International
Director, Materials Chemistry
Discovery Innovations Mar 2012 - Dec 2014
Principal and Co-Founder
Scynexis, Inc. Oct 2003 - Jan 2012
Senior Research Scientist
University of Vermont Jun 2001 - Sep 2003
Post-Doc

Education:

University of Orleans - France 1996 - 2001
Doctorates, Doctor of Philosophy, Chemistry University Hassan Ii - Morocco 1995 - 1996
Master of Science, Masters, Chemistry, Organic Chemistry

Skills:

Medicinal Chemistry
Drug Design
Drug Discovery
Organic Chemistry
Synthetic Chemistry
Lead Optimization
R&D
Pharmacokinetics
Organic Synthesis
Heterocyclic Chemistry
Drug Metabolism
Chemistry
Cross Functional Team Leadership
Natural Products
Matrix Management
Supervisory Experience
Mentoring
Adme
Pharmaceutical Industry
Lead Change
Biotechnology
Drug Development
Purification
Synthetic Organic Chemistry
Clinical Development
Small Molecules

Sr. Research Scientist At Scynexis

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Location:

Raleigh-Durham, North Carolina Area

Industry:

Pharmaceuticals

Mustapha Soukri Raleigh, NC

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Work:

DISCOVERY INNOVATIONS, LLC

Mar 2012 to 2000
PRINCIPAL & CO-FOUNDER SCYNEXIS, Inc
Durham, NC
Oct 2003 to Jan 2012
Senior Research Scientist

Education:

University of Vermont
Burlington, VT
2001 to 2003
doctoral University of Orlans
1996 to 2001
Ph.D. in Chemistry University Hassan II
1995 to 1996
MSc in Chemistry

Mustapha Soukri

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Vehicle Records

Mustapha Soukri
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Address:

7815 Clover Crk Ct, Raleigh, NC 27613
VIN:

5FNYF3H47AB019108
Make:

HONDA
Model:

PILOT
Year:

2010

Us Patents

Fluoro-Substituted Inhibitors Of D-Amino Acid Oxidase
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US Patent:

7884124, Feb 8, 2011
Filed:

Jul 2, 2007
Appl. No.:

11/772798
Inventors:

Michele L. R. Heffernan - Worcester MA, US
Robert J. Foglesong - Durham NC, US
Seth C. Hopkins - Clinton MA, US
Mustapha Soukri - Raleigh NC, US
Steven W. Jones - Milford MA, US
Kerry L. Spear - Concord MA, US
Mark A. Varney - Laguna Niguel CA, US
Assignee:

Sepracor Inc. - Marlborough MA
International Classification:

A61K 31/40
C07D 487/02
C07D 491/02
C07D 495/02
C07D 497/02
US Classification:

514412, 548453
Abstract:

This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. The invention also provides methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure:.

Inhibitors Of D-Amino Acid Oxidase
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US Patent:

7902252, Mar 8, 2011
Filed:

Jul 20, 2009
Appl. No.:

12/506204
Inventors:

Michele L. R. Heffernan - Worcester MA, US
Qun Kevin Fang - Wellesley MA, US
Robert J. Foglesong - Durham NC, US
Seth C. Hopkins - Clinton MA, US
Cyprian O. Ogbu - Durham NC, US
Mustapha Soukri - Raleigh NC, US
Kerry L. Spear - Concord MA, US
Assignee:

Sepracor, Inc. - Marlborough MA
International Classification:

A61K 31/403
C07D 209/02
US Classification:

514423, 548531
Abstract:

The present invention provides novel inhibitors of the enzyme D-amino acid oxidase. The compounds of the invention are useful for treating or preventing diseases and/or condition, wherein modulation of D-serine levels, and/or its oxidative products, is effective in ameliorating symptoms. The invention further provides methods of enhancing learning, memory and/or cognition. For example, the invention provides methods for treating or preventing loss of memory and/or cognition associated with neurodegenerative diseases, such as Alzheimer's disease. The invention further provides methods for preventing loss of neuronal function characteristic of neurodegenerative diseases. In addition, methods are provided for the treatment or prevention of neuropsychiatric diseases (e. g. , schizophrenia) and for the treatment or prevention of pain and ataxia.

Fused Heterocycles
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US Patent:

20080004328, Jan 3, 2008
Filed:

Aug 3, 2007
Appl. No.:

11/833903
Inventors:

James Dorsey - Durham NC, US
Michele Heffernan - Worcester MA, US
Qun Fang - Wellesley MA, US
Robert Foglesong - Durham NC, US
Seth Hopkins - Clinton MA, US
Cyprian Ogbu - Durham NC, US
Mustapha Soukri - Raleigh NC, US
Kerry Spear - Concord MA, US
Assignee:

SEPRACOR INC. - Marlborough MA
International Classification:

A61K 31/407
US Classification:

514412000
Abstract:

This invention provides fused heterocycles having the formula: in which Ris a member selected from the group consisting of H, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. Ris a member selected from the group consisting of H substituted or unsubstituted alkenyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. Ris a member selected from the group consisting of H, C-Csubstituted or unsubstituted alkyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. Ris a member selected from OH and OX, in which X is positive ion which is a member selected from organic positive ions and inorganic positive ions. Substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl moieties have the formula: in which Ar is a member selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl. The index n is an integer from 1 to 4.

Fused Heterocyclic Inhibitors Of D-Amino Acid Oxidase
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US Patent:

20080058395, Mar 6, 2008
Filed:

Jul 2, 2007
Appl. No.:

11/825093
Inventors:

Michele Heffernan - Worcester MA, US
James Dorsey - Durham NC, US
Qun Fang - Wellesley MA, US
Robert Foglesong - Durham NC, US
Seth Hopkins - Clinton MA, US
Michael Jones - Chapel Hill NC, US
Steven Jones - Milford MA, US
Cyprian Ogbu - Durham NC, US
Joe Perales - Durham NC, US
Mustapha Soukri - Raleigh NC, US
Kerry Spear - Concord MA, US
Mark Varney - Laguna Niguel CA, US
Assignee:

SEPRACOR INC. - Marlborough MA
International Classification:

A61K 31/40
A61K 31/415
A61K 31/425
A61K 31/48
A61P 43/00
C07D 231/02
C07D 303/02
C07D 487/02
C07D 513/00
US Classification:

514367000, 514403000, 514421000, 514443000, 548153000, 548356500, 548453000, 549550000
Abstract:

This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. Also provided are methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure: wherein Q is a member selected from O, S, CRand N, X and Y are members independently selected from CR, O, S, N and NR.

Inhibitors Of D-Amino Acid Oxidase
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US Patent:

20090099248, Apr 16, 2009
Filed:

Jan 18, 2008
Appl. No.:

12/016954
Inventors:

Michele L. R. Heffernan - Worcester MA, US
Qun Kevin Fang - Wellesley MA, US
Robert J. Foglesong - Durham NC, US
Seth C. Hopkins - Clinton MA, US
Cyprian O. Ogbu - Durham NC, US
Mustapha Soukri - Raleigh NC, US
Kerry L. Spear - Concord MA, US
Assignee:

SEPRACOR INC. - Marlborough MA
International Classification:

A61K 31/404
C07D 209/02
C07D 209/42
A61P 25/00
C12N 9/99
A61K 31/403
US Classification:

514419, 548516, 514412, 548492, 435184
Abstract:

The present invention provides novel inhibitors of the enzyme D-amino acid oxidase. The compounds of the invention are useful for treating or preventing diseases and/or condition, wherein modulation of D-serine levels, and/or its oxidative products, is effective in ameliorating symptoms. The invention further provides methods of enhancing learning, memory and/or cognition. For example, the invention provides methods for treating or preventing loss of memory and/or cognition associated with neurodegenerative diseases, such as Alzheimer's disease. The invention further provides methods for preventing loss of neuronal function characteristic of neurodegenerative diseases. In addition, methods are provided for the treatment or prevention of neuropsychiatric diseases (e.g., schizophrenia) and for the treatment or prevention of pain and ataxia.

Fused Heterocycles
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US Patent:

20100022612, Jan 28, 2010
Filed:

Aug 7, 2009
Appl. No.:

12/537925
Inventors:

James M. Dorsey - Durham NC, US
Michele L. R. Heffernan - Worcester MA, US
Qun Kevin Fang - Wellesley MA, US
Robert J. Foglesong - Durham NC, US
Seth C. Hopkins - Clinton MA, US
Cyprian O. Ogbu - Durham NC, US
Mustapha Soukri - Raleigh NC, US
Kerry L. Spear - Concord MA, US
Assignee:

Sepracor Inc. - Marlborough MA
International Classification:

A61K 31/407
A61P 29/00
US Classification:

514412
Abstract:

This invention provides fused heterocycles having the formula:in which Ris a member selected from the group consisting of H, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. Ris a member selected from the group consisting of H substituted or unsubstituted alkenyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. Ris a member selected from the group consisting of H, C-Csubstituted or unsubstituted alkyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. Ris a member selected from OH and OX, in which X is positive ion which is a member selected from organic positive ions and inorganic positive ions. Substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl moieties have the formula:in which Ar is a member selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl. The index n is an integer from 1 to 4.

Fused Heterocycles
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US Patent:

20100029741, Feb 4, 2010
Filed:

Aug 7, 2009
Appl. No.:

12/537896
Inventors:

James M. Dorsey - Durham NC, US
Michele L. R. Heffernan - Worcester MA, US
Qun Kevin Fang - Wellesley MA, US
Robert J. Foglesong - Durham NC, US
Seth C. Hopkins - Clinton MA, US
Cyprian O. Ogbu - Durham NC, US
Mustapha Soukri - Raleigh NC, US
Kerry L. Spear - Concord MA, US
Assignee:

Sepracor Inc. - Marlborough MA
International Classification:

A61K 31/407
A61P 25/00
US Classification:

514412
Abstract:

This invention provides methods of improving cognitive function by administering to a subject a therapeutically effective amount of a fused heterocycle having the formula:in which Ris a member selected from the group consisting of H, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. Ris a member selected from the group consisting of H substituted or unsubstituted alkenyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. Ris a member selected from the group consisting of H, C-Csubstituted or unsubstituted alkyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. Ris a member selected from OH and OX, in which X is positive ion which is a member selected from organic positive ions and inorganic positive ions. Substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl moieties have the formula:in which Ar is a member selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl. The index n is an integer from 1 to 4.

Prodrugs Of Fused Heterocyclic Inhibitors Of D-Amino Acid Oxidase
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US Patent:

20100120740, May 13, 2010
Filed:

Aug 6, 2009
Appl. No.:

12/537104
Inventors:

Michele L. R. Heffernan - Worcester MA, US
Richard Dennis - Garner NC, US
James M. Dorsey - Durham NC, US
Robert J. Foglesong - Durham NC, US
Michael L. Jones - Chapel Hill NC, US
Cyprian O. Ogbu - Durham NC, US
Mustapha Soukri - Raleigh NC, US
Kerry L. Spear - Concord MA, US
H. Scott Wilkinson - Westborough MA, US
Michael Anthony Orsini - Leominster MA, US
Assignee:

SEPRACOR INC. - Marlborough MA
International Classification:

A61K 31/407
C07D 491/048
A61K 31/497
A61K 31/5377
US Classification:

51421018, 548453, 514414, 544373, 51425304, 544143, 5142338
Abstract:

The invention relates to prodrugs of fused heterocyclic inhibitors of D-amino oxidase (DAAO) and methods of treating diseases and conditions, wherein modulation of D-amino acid oxidase activity, D-serine levels, D-serine oxidative products and NMDA receptor activity in the nervous system of a mammalian subject is effective.