Neel K Krishna

US Patent:

20080286294, Nov 20, 2008

Filed:

May 19, 2005

Appl. No.:

11/596860

Inventors:

Richard Thiery - Biot, FR
Marine Baud - Brest, FR
Joelle Cabon - Plabennec, FR
Joelle Cozien - Ploumoguer, FR
Francois Lamour - Brest, FR
Chan-Shing Lin - Surrey, CA
Neel Krishna - Norfolk VA, US
John E. Johnson - San Diego CA, US
Anette Schneemann - San Diego CA, US

Assignee:

AGENCE FRANCAISE DE SECURITE SANITAIRE DES ALIMENT - Maisons-Alfort
THE SCRIPPS RESEARCH INSTITUTE - La Jolla CA

International Classification:

A61K 39/12

US Classification:

4241861, 4242041

Abstract:

The present invention relates to an immunogenic composition for fish comprising nodavirus virus-like particles (VLPs) formed with nodavirus capsid protein assembly, for use as a vaccine. This composition is suitable for administration to fish via the intramuscular or intraperitoneal route, or by bath and/or via the oral route. The invention also relates to the use of such VPLs for the manufacturing of a vaccine for treating or preventing fish against a nodavirus infection. Fish farming baths and concentrates comprising the nodavirus VLP composition, as well as fish farming methods, are also encompassed in the present invention.

US Patent:

20100055106, Mar 4, 2010

Filed:

May 25, 2007

Appl. No.:

12/304717

Inventors:

Neel K. Krishna - Norfolk VA, US
Kenji Cunnion - Norfolk VA, US

Assignee:

EASTERN VIRGINIA MEDICAL SCHOOL - Norfolk VA

International Classification:

A61K 39/12
C07K 14/005
A61K 38/16
A61K 39/395
A61P 31/12

US Classification:

4241411, 530350, 530300, 514 12, 4242041, 4241991

Abstract:

The present invention provides a method for modulating the complement cascade by depleting the plasma of the functional activity of complement proteins and thereby reducing or eliminating complement-mediated cell lysis. The invention provides a method for the therapeutic use of coat proteins and derivatives thereof from the Astroviradae family of viruses in the treatment of complement-mediated cell lysis and peptide mediators of inflammation. The invention provides a method for the therapeutic use of coat proteins and derivatives thereof from the Astroviradae family of viruses in the treatment of complement-mediated diseases. Methods are described herein where complement cascade, triggered by either the classical or alternative complement pathways, is prevented from effecting cell lysis and inflammation due to inhibition or depletion of one or more complement components in the serum following administration of astrovirus coat proteins or derivatives.

US Patent:

20130058972, Mar 7, 2013

Filed:

Jul 17, 2012

Appl. No.:

13/551478

Inventors:

Neel K. KRISHNA - Norfolk VA, US
Kenji CUNNION - Norfolk VA, US

Assignee:

EASTERN VIRGINIA MEDICAL SCHOOL - Norfolk VA

International Classification:

A61K 39/12
A61P 19/04
A61P 25/00
A61P 21/04
A61P 7/06
A61P 17/02
A61P 31/12
A61P 11/00
A61P 9/10
A61P 37/06
A61P 25/28
A61P 29/00
A61P 13/12

US Classification:

4242041

Abstract:

The present invention provides a method for modulating the complement cascade by depleting the plasma of the functional activity of complement proteins and thereby reducing or eliminating complement-mediated cell lysis. The invention provides a method for the therapeutic use of coat proteins and derivatives thereof from the Astroviradae family of viruses in the treatment of complement-mediated cell lysis and peptide mediators of inflammation. The invention provides a method for the therapeutic use of coat proteins and derivatives thereof from the Astroviradae family of viruses in the treatment of complement-mediated diseases. Methods are described herein where complement cascade, triggered by either the classical or alternative complement pathways, is prevented from effecting cell lysis and inflammation due to inhibition or depletion of one or more complement components in the serum following administration of astrovirus coat proteins or derivatives.

US Patent:

20130244924, Sep 19, 2013

Filed:

Jul 21, 2011

Appl. No.:

13/809371

Inventors:

Neel K. Krishna - Norfolk VA, US
Kenji M. Cunnion - Norfolk VA, US

International Classification:

C07K 14/08
A61K 45/06
A61K 38/16

US Classification:

514 11, 530324, 530326

Abstract:

The disclosure provides peptide compounds that regulate the complement system and methods of using these compounds. Specifically the disclosure provides an isolated, purified peptide of 30 amino acids derived from human astrovirus protein, called CP1. The peptide compounds disclosed include peptide mimetics, peptide analogs and/or synthetic derivatives of CP1 having, for example, internal peptide deletions and/or substitutions, deletions and/or substitutions at the N-terminus and C-terminus, and that are able to regulate complement activation. The disclosure further provides pharmaceutical compositions comprising therapeutically effective amounts of the peptide compounds and a pharmaceutically acceptable carrier, diluent, or excipient for treating a disease or condition associated with complement-mediated tissue damage.