Clarence J. Maring - Palatine IL Yu Gui Gu - Grayslake IL Hui-Ju Chen - Grayslake IL Yuanwei Chen - North Haven CT David A. Degoey - Kenosha WI William J. Flosi - Des Plaines IL Vincent L. Giranda - Gurnee IL David J. Grampovnik - Waukegan IL Warren M. Kati - Gurnee IL Dale J. Kempf - Libertyville IL April Kennedy - Boulder CO Larry L. Klein - Lake Forest IL Allan C. Krueger - Gurnee IL Zhen Lin - Gurnee IL Darold L. Madigan - Elk Grove Village IL Keith F. McDaniel - Wauconda IL Steven W. Muchmore - Libertyville IL Hing L. Sham - Mundelein IL Kent D. Stewart - Gurnee IL Vincent S. Stoll - Libertyville IL Minghua Sun - Libertyville IL Noah P. Tu - Gurnee IL Frank L. Wagenaar - Gurnee IL Gary T. Wang - Niles IL Sheldon Wang - Grayslake IL Paul E. Wiedeman - Deerfield IL Yibo Xu - New Milford CT Ming C. Yeung - Grayslake IL Chen Zhao - Libertyville IL Stephen Hanessian - Beaconsfield, CA Malken Bayrakdarian - Verdun, CA Xuehong Luo - Montreal, CA
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
A61K 3140
US Classification:
514423
Abstract:
Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
Milan Bruncko - Green Oaks IL, US Hong Ding - Gurnee IL, US Steven Elmore - Northbrook IL, US Aaron Kunzer - Arlington Heights IL, US Christopher L. Lynch - Trevor WI, US William McClellan - Waukegan IL, US Cheol-Min Park - Singapore, SG Andrew Petros - Mundelein IL, US Xiaohong Song - Grayslake IL, US Xilu Wang - Grayslake IL, US Noah Tu - Gurnee IL, US Michael Wendt - Vernon Hills IL, US Alexander Shoemaker - Green Oaks IL, US Michael Mitten - Beach Park IL, US
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C07D 241/02 C07D 403/02
US Classification:
544393, 544121
Abstract:
Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
Milan Bruncko - Green Oaks IL, US Hong Ding - Gurnee IL, US Steven Elmore - Gurnee IL, US Aaron R. Kunzer - Schaumburg IL, US Christopher L. Lynch - Trevor WI, US William J. McClellan - Waukegan IL, US Cheol-min Park - Gurnee IL, US Andrew M. Petros - Mundelein IL, US Xiaohong Song - Grayslake IL, US Noah P. Tu - Gurnee IL, US Xilu Wang - Oakwood IL, US Michael D. Wendt - Vernon Hills IL, US
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C07D 241/04 C07D 295/00
US Classification:
544392, 544395
Abstract:
Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
Milan Bruncko - Green Oaks IL, US Hong Ding - Gurnee IL, US Steven Elmore - Northbrook IL, US Aaron Kunzer - Arlington Heights IL, US Christopher L. Lynch - Trevor WI, US William McClellan - Waukegan IL, US Cheol-Min Park - Singapore, SG Andrew Petros - Mundelein IL, US Xiaohong Song - Grayslake IL, US Xilu Wang - Grayslake IL, US Noah Tu - Gurnee IL, US Michael Wendt - Vernon Hills IL, US Alexander Shoemaker - Green Oaks IL, US Michael Mitten - Beach Park IL, US
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C07D 241/04 A61K 31/496
US Classification:
5142312, 51425212, 544129, 544392
Abstract:
Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
Milan Bruncko - Green Oaks IL, US Hong Ding - Gurnee IL, US Steven Elmore - Northbrook IL, US Aaron Kunzer - Schaumburg IL, US Christopher L. Lynch - Trevor WI, US William McClellan - Waukegan IL, US Cheol-Min Park - Gurnee IL, US Andrew Petros - Mundelein IL, US Xiaohong Song - Grayslake IL, US Xilu Wang - Grayslake IL, US Noah Tu - Gurnee IL, US Michael Wendt - Vernon Hills IL, US Alexander R. Shoemaker - Green Oaks IL, US Michael J. Mitten - Beach Park IL, US
Assignee:
AbbVie Inc. - North Chicago IL
International Classification:
C07D 211/06 C07D 413/02
US Classification:
544121, 544366, 544368, 546198, 546199
Abstract:
Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
NWE Y. BAMAUNG - NILES IL, US ANWER BASHA - LAKE FOREST IL, US STEVAN W. DJURIC - LIBERTYVILLE IL, US EARL J. GUBBINS - LIBERTYVILLE IL, US JAY R. LULY - WELLESLEY MA, US NOAH P. TU - GURNEE IL, US DAVID J. MADAR - GRAYSLAKE IL, US USHA WARRIOR - GREEN OAKS IL, US PAUL E. WIEDEMAN - LIBERTYVILLE IL, US XUN ZHOU - PARK CITY IL, US RICHARD J. SCIOTTI - GURNEE IL, US FRANK L. WAGENAAR - GURNEE IL, US
Compounds having the formula are useful for treating diseases that are prevented by or ameliorated with Interleukin-2, Interleukin-4, or Interleukin-5 production inhibitors.
Milan Bruncko - Green Oaks IL, US Hong Ding - Gurnee IL, US Steven Elmore - Gurnee IL, US Aaron Kunzer - Schaumburg IL, US Christopher Lynch - Trevor WI, US William McClellan - Waukegan IL, US Cheol-Min Park - Gurnee IL, US Andrew Petros - Mundelein IL, US Xiaohong Song - Grayslake IL, US Xilu Wang - Grayslake IL, US Noah Tu - Gurnee IL, US Michael Wendt - Vernon Hills IL, US Alexander Shoemaker - Green Oaks IL, US Michael Mitten - Beach Park IL, US
Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
Abbott Laboratories - Abbott Park IL, US Hong Ding - Gurnee IL, US Steven Elmore - Northbrook IL, US Aaron Kunzer - Schaumburg IL, US Christopher L. Lynch - Trevor WI, US William McClellan - Waukegan IL, US Cheol-Min Park - Singapore, SG Andrew Petros - Mundelein IL, US Xiaohong Song - Grayslake IL, US Xilu Wang - Grayslake IL, US Noah Tu - Gurnee IL, US Michael Wendt - Vernon Hills IL, US Alexander Shoemaker - Green Oaks IL, US Michael Mitten - Beach Park IL, US
Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
Abbvie
Senior Scientist
Abbott 2006 - 2011
Senior Research Chemist
S*Bio Pte Ltd Jan 2002 - Jun 2006
Scientist
Abbott Jul 1994 - Jan 2001
Research Chemist
Education:
University of Victoria Jan 1, 1991 - 1994
Master of Science, Masters
The University of Lethbridge Jan 1, 1989 - 1991
Bachelors, Bachelor of Science, Chemistry
Skills:
Microsoft Office Management Microsoft Excel Leadership Microsoft Word Powerpoint Research Training Process Improvement Project Management Medicinal Chemistry Lead Change Organic Synthesis Drug Discovery