Nahum Sonenberg - Quebec, CA Anne-Claude Gingras - Quebec, CA Peter Bitterman - Edina MN, US
International Classification:
A61K038/17
US Classification:
514/012000
Abstract:
More than 30% of human malignancies harbor encogenic Ras. Both pro-apoptotic and anti-apoptotic pathways emanate from encogenic Ras with survival being dominant. Ras survival signaling is thought to be controlled by transcriptional and post-translational processes. The present invention shows that a repressor of cap-dependent translation initiation, 4E-BP1, selectively activates apoptosis in Ras-transformed fibroblasts and eliminates Ras-induced chemoresistance. These effects of 4E-BP1 are strictly dependent on its ability to sequester translation initiation factor eIF4E, thereby preventing its assembly into an active pre-initiation complex. These results suggest that translational control is critical for prevention of apoptosis and resistance to antitumor agents in Ras-transformed cells.
Name / Title
Company / Classification
Phones & Addresses
Peter Bruce Bitterman Medical Doctor
Bruce Cunningham Medical Doctor's Office · Surgeons · Plastic Surgery · Internist
516 Delaware St SE, Minneapolis, MN 55455 PO Box 195, Minneapolis, MN 55440 6126251188
Peter Bruce Bitterman
Peter Bitterman MD Dermatologist · Emergency Medicine · Pulmonologist · Plastic Surgery · Internist
420 Delaware St SE, Minneapolis, MN 55455 6126263003
Peter Bitterman Manager
Regents of The University of Minnesota Medical Doctor's Office
PO Box 99, Minneapolis, MN 55440 Minneapolis, MN 55440 6126265456
Medicine Doctors
Dr. Peter B Bitterman, Minneapolis MN - MD (Doctor of Medicine)
516 Delaware St Se, Minneapolis, MN 55455 6126266100 (Phone)
Certifications:
Critical Care Medicine, 1989 Internal Medicine, 1979 Pulmonary Disease, 1982
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School Yale University School Of Medicine Graduated: 1976 Medical School University Of Chicago Graduated: 1977 Medical School Nih Graduated: 1979 Medical School University Of Chicago Graduated: 1978 Medical School Nih Graduated: 1982
University Minnesota PhysiciansUniversity Of Minnesota Center For Lung Science & Health 909 Fulton St SE FL 3, Minneapolis, MN 55455 6126244040 (phone), 6126765081 (fax)
Education:
Medical School Yale University School of Medicine Graduated: 1976
720 Washington Ave Se, Minneapolis, MN 55414 420 Delaware St Se, Minneapolis, MN 55455
Education:
Yale University, School of Medicine - Doctor of Medicine
Board certifications:
American Board of Internal Medicine Certification in Internal Medicine American Board of Internal Medicine Sub-certificate in Pulmonary Disease (Internal Medicine)