Dr. Liu graduated from the Tongji Med Univ, Wuhan City, Hubei, China in 1992. She works in Newton, NJ and specializes in Internal Medicine. Dr. Liu is affiliated with Overlook Medical Center.
William K. Hagmann - Westfield NJ, US Linus S. Lin - Westfield NJ, US Shrenik K. Shah - Metuchen NJ, US Ravindra N. Guthikonda - Edison NJ, US Hongbo Qi - Edison NJ, US Linda L. Chang - Wayne NJ, US Ping Liu - Edison NJ, US Helen M. Armstrong - Westfield NJ, US James P. Jewell - Jersey City NJ, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K031/4412 C07D213/70
US Classification:
514345, 546290
Abstract:
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
William K. Hagmann - Westfield NJ, US Linus S. Lin - Westfield NJ, US Ping Liu - Westfield NJ, US Richard A. Mumford - Red Bank NJ, US Thomas S. Reger - San Diego CA, US Nicholas D. Smith - San Diego CA, US Nicholas S. Stock - San Diego CA, US Jasmine Zunic - San Diego CA, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 38/05
US Classification:
514 19
Abstract:
Compounds of Formula I are antagonists of VLA-4, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of inflammatory bowel disease including ulcerative colitis and Crohn's disease, multiple sclerosis, asthma, and rheumatoid arthritis.
William K. Hagmann - Westfield NJ, US Linus S. Lin - Westfield NJ, US Shrenik K. Shah - Metuchen NJ, US Ravindra N. Guthikonda - Edison NJ, US Hongbo Qi - Edison NJ, US Linda L. Chang - Wayne NJ, US Ping Liu - Edison NJ, US Helen M. Armstrong - Westfield NJ, US James P. Jewell - Jersey City NJ, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 31/435
US Classification:
514354, 514355
Abstract:
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
William K. Hagmann - Westfield NJ, US Linus S. Lin - Westfield NJ, US Shrenik K. Shah - Metuchen NJ, US Ravindra N. Guthikonda - Edison NJ, US Hongbo Qi - Edison NJ, US Linda L. Chang - Wayne NJ, US Ping Liu - Edison NJ, US Helen M. Armstrong - Westfield NJ, US James P. Jewell - Jersey City NJ, US
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
Substituted Diazepine Sulfonamides As Bombesin Receptor Subtype-3 Modulators
Robert K. Baker - Cranford NJ, US Linda L. Chang - Wayne NJ, US Marc Chioda - Metuchen NJ, US Harry R. Chobanian - Aberdeen NJ, US Yan Guo - Westfield NJ, US Linus S. Lin - Westfield NJ, US Ping Liu - Westfield NJ, US Ravi P. Nargund - East Brunswick NJ, US Kathleen M. Rupprecht - Cranford NJ, US Shouwu Miao - Edison NJ, US
Certain novel substituted diazepine sulfonamides are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.
Imidazole Derivatives Useful As Inhibitors Of Faah
Linus S. Lin - Westfield NJ, US Marc D. Chioda - Metuchen NJ, US Ping Liu - Westfield NJ, US Ravi P. Nargund - East Brunswick NJ, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
A61K 31/4174 A61K 31/4178 C07D 233/84
US Classification:
514397, 5483111
Abstract:
The present invention is directed to certain imidazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzeimer Disease, and Parkinson's Disease.
William Hagmann - Westfield NJ, US Linus Lin - Westfield NJ, US Shrenik Shah - Metuchen NJ, US Ravindra Guthikonda - Edison NJ, US Hongbo Qi - Edison NJ, US Linda Chang - Wayne NJ, US Ping Liu - Edison NJ, US Helen Armstrong - Westfield NJ, US James Jewell - Jersey City NJ, US Thomas Lanza - Edison NJ, US
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
Acyclic Hydrazides As Cannabinoid Receptor Modulators
The acyclic hydrazides of the invention are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders (including smoking cessation), the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
2014 to 2000 Principal Statistician3M Pharmaceuticals, Inc
May 2005 to Feb 2012 Statistician/lead statistician on severalUS and Europe
Aug 2000 to Apr 2005 Lead statistician in Actinic Keratosis projectUniversity of Minnesota
Sep 1998 to Jun 2000 Consultant
Education:
The University of Texas 2007 to 2012 Ph.D in BiostatisticsUniversity of Minnesota 1998 to 2000 M.S in BiostatisticsFudan University 1992 to 1997 B.S in Genetics & Genetic EngineeringFudan University