Ratnesh Singh

US Patent:

20220354896, Nov 10, 2022

Filed:

Apr 28, 2020

Appl. No.:

17/606990

Inventors:

- Carlsbad CA, US
Ratnesh SINGH - Carlsbad CA, US
Francois BINETTE - Carlsbad CA, US

International Classification:

A61K 35/30
C12N 5/079
A61P 27/02
A61K 9/00

Abstract:

Presented herein are compositions and methods for generating stem cell derived retinal tissue and isolated retinal progenitor cells for use in the treatment of retinal degenerative diseases and disorders.

US Patent:

20200368394, Nov 26, 2020

Filed:

Jul 31, 2018

Appl. No.:

16/635473

Inventors:

- Alameda CA, US
Ratnesh SINGH - San Ramon CA, US
Oscar CUZZANI - Walnut Creek CA, US
Michael ONORATO - San Francisco CA, US
Francois BINETTE - Napa CA, US

Assignee:

Lineage Therapeutics, Inc. - Carlsbad CA

International Classification:

A61L 27/36
A61K 35/545
A61K 31/137
A61F 2/14
A61L 27/54

Abstract:

Bioprosthetic retinal grafts (or devices) comprising stem cell derived tissues and/or cells may be used to slow the progression of retinal degenerative disease, slow the progression of retinal degenerative disease after traumatic injury, slow the progression of age related macular degeneration (AMD), prevent retinal degenerative disease, prevent retinal degenerative disease after traumatic injury, prevent AMD, restore retinal pigment epithelium (RPE), photoreceptor cells (PRCs) and retinal ganglion cells (RGCs) lost from disease, injury or genetic abnormalities, increasing RPE, PRCs and RCGs, treat RPE, PRCs and RCG defects in a subject, or for other purposes. Bioprosthetic retinal grafts may comprise a bioprosthetic carrier or scaffold suitable for implantation into the ocular space of a subject's eye, to form a bioprosthetic retinal patch. In certain embodiments, the bioprosthetic retinal patch may comprise multiple pieces of stem cell derived tissues or cells on a carrier or scaffold, which may be used to treat large areas of retinal degeneration or damage, or for other purposes.