Richard J Gross

Address:

2391 Lakeside Mews, Sarasota, FL 34235

Phone:

9413202700

VIN:

5NPDH4AE8CH108966

Make:

HYUNDAI

Model:

ELANTRA

Year:

2012

US Patent:

6566469, May 20, 2003

Filed:

Jun 22, 2000

Appl. No.:

09/602649

Inventors:

David Kaplan - Loveland MA
Graham Swift - Brooklyn NY
Richard A. Gross - Brooklyn NY
Bhanu Kalra - Blue Bell PA

Assignee:

Trustees of Tufts College - Medford MA
Rohm Haas Company - Philadelphia PA
Polytechnic Institute of New York - Brooklyn NY

International Classification:

C08F 430

US Classification:

526229, 526 89, 526199, 526208, 5263031, 526310, 5263171, 526318, 526319, 5263292, 526227

Abstract:

A method for polymerization of substituted ethylene monomers in an enzyme-mediated process is disclosed. The reaction proceeds under mild conditions with a wide variety of monomers, and is capable of producing stereoregular polymers. In certain embodiments, no organic solvent is necessary.

US Patent:

7485743, Feb 3, 2009

Filed:

Jul 19, 2005

Appl. No.:

11/632995

Inventors:

Richard A. Gross - Brooklyn NY, US

Assignee:

BTG International Limited - London

International Classification:

C07C 69/66
A61K 31/215
A61K 31/12
A61K 47/00

US Classification:

560174, 560185, 514529, 514675, 424439

Abstract:

A novel keto8enic compound is provided having general: Formula R(OCH(CH)CHC(O))—O-A wherein n is an integer of 3 to 10, A is the residue of a 3-keto alkan-1-ol and R is selected from the group consisting of H, C1-C6 alkyl and acetoacetyl- Preferred compounds are those wherein A is a residue is of 4-hydroxy-2 butanone. A particularly preferred compound is a 4-hydroxy-2-butanone ester of an R-3-hydroxybutyrate oligomer having general: Formula H(OCH(CH)CHC(O))—O—CH—CH—(CO)—CHNutraceutical and pharmaceutical compositions are provided for use in treating one or more of acute trauma, hemorrhagic shock, neurodegeneration, diabetes, and epilepsy, stroke, head trauma, myocardial infraction, congestive heart failure, pulmonary failure, kidney failure, obesity depression, pain and impaired cognition.

US Patent:

7947736, May 24, 2011

Filed:

Jul 15, 2005

Appl. No.:

11/632638

Inventors:

Richard A. Gross - Brooklyn NY, US

Assignee:

BTG International Limited - London

International Classification:

A61K 31/225
A61K 47/00
C07C 69/66

US Classification:

514547, 560185, 424439

Abstract:

Method for the synthesis of a compound of formula H(OCH[CH]CHC[O])—O-A-O—R wherein A is the residue of 1,3-butandiol and R is H or H(OCH[CH]CHC[O]—. The method comprises reacting a cyclic oligomer of (R)-3-hydroxybutyrate consisting of (R)-3-hydroxybutyrate moieties with a 1,3-butandiol in an organic solvent in the presence of lipase type B in a furan or pyran solvent.

US Patent:

8137688, Mar 20, 2012

Filed:

Feb 27, 2009

Appl. No.:

12/380469

Inventors:

Peter A. Zahos - Harrington Park NJ, US
Anthony Calabro - Cleveland Heights OH, US
Aniq B. Darr - Piscataway NJ, US
Richard A. Gross - Plainview NY, US

Assignee:

The Cleveland Clinic Foundation - Cleveland OH

International Classification:

C08G 63/91
C08G 65/48
A61K 31/775

US Classification:

424423, 424426, 514 53, 514 54, 525 541, 525 542, 5253262, 525420, 525540

Abstract:

A synthetic nucleus pulposus is provided that is useful in treatment of degenerative disc disease, augmentation of a degenerate disc, and alleviation of back pain. In an embodiment the synthetic nucleus pulposus comprises hyaluronan macromolecules that have been cross-linked via dihydroxyphenyl linkages. The synthetic nucleus pulposus restores or improves the water-retention capability of the disc. A method of treating an intervertebral disc with the cross-linked hyaluronan macromolecules is also provided. A method of regenerative therapy to address loss of cells of nucleus pulposus of an intervertebral disc based on treatment with the cross-linked hyaluronan macromolecules and mesenchymal stem cells is also provided.

US Patent:

8158391, Apr 17, 2012

Filed:

May 6, 2009

Appl. No.:

12/436729

Inventors:

Richard A. Gross - New York NY, US
Wenhua Lu - Brooklyn NY, US
Jon Ness - Redwood City CA, US
Jeremy Minshull - Los Altos CA, US

Assignee:

DNA Twopointo, Inc. - Menlo Park CA

International Classification:

C12P 7/64
C12N 9/00
C12N 1/00
C12N 15/00
C12N 15/74

US Classification:

435134, 435183, 43525422, 4353201, 435471, 536 232

Abstract:

A substantially pure host cell for the production of a α-carboxyl-ω-hydroxy fatty acid having a carbon chain length in the range from C6 to C22, a α,ω-dicarboxylic fatty acid having a carbon chain length in the range from C6 to C22, or mixtures thereof, is provided. The host cell is characterized by a first genetic modification class and a second genetic modification class. The first genetic modification class comprises one or more genetic modifications that disrupt the peroxisomal β-oxidation pathway. The second genetic modification class comprises one or more genetic modifications that collectively or individually disrupt at least one gene selected from the group consisting of a CYP52A type cytochrome P450, a fatty alcohol oxidase, and an alcohol dehydrogenase.

US Patent:

20070225252, Sep 27, 2007

Filed:

Jul 22, 2005

Appl. No.:

11/658154

Inventors:

Richard Gross - Brooklyn NY, US

International Classification:

A61K 31/715
A61K 31/7004
C07H 3/02

US Classification:

514054000, 514023000, 536001110, 536123100

Abstract:

A novel ketogenic compound is provided having general formula (R(OCH(CH)CHC(O))O)-A wherein n is a integer between 1 and 10, m is an integer of 1 to 200,000, A is a monsaccharide, polysaccharide or oligosaccharide residue and R is selected from the group consisting of H, C-Calkyl and acetoacetyl-.

US Patent:

20080182982, Jul 31, 2008

Filed:

Jan 23, 2008

Appl. No.:

12/018238

Inventors:

Vineer Kumar - East Brunswick NJ, US
Fanny Longin - Frederiksberg, DK
Khadija Schwach-Abdellaoui - Frederiksberg, DK
Richard A. Gross - Plainview NY, US

Assignee:

Novozymes Biolpolymer A/S - Bagsvaerd

International Classification:

C08B 37/00

US Classification:

536 553

Abstract:

The present invention relates to a method of producing methyl esters of a hyaluronic acid, said method comprising the steps of:

US Patent:

20090186835, Jul 23, 2009

Filed:

Jan 14, 2009

Appl. No.:

12/353571

Inventors:

Richard A. Gross - New York NY, US
Martin H. Bluth - Detroit MI, US

International Classification:

A61K 31/7028
A61P 35/00

US Classification:

514 25

Abstract:

A method and composition for the prophylaxis or treatment of humans or animals for cancer using a mixture of sophorolipids.