Richard S Rosen

US Patent:

20020095257, Jul 18, 2002

Filed:

Mar 26, 2001

Appl. No.:

09/817760

Inventors:

Richard Rosen - New York NY, US
Erik Kruger - Cambridge MA, US
Alvin Katz - Bronx NY, US
Robert Alfano - Bronx NY, US

International Classification:

G06F019/00
G01N033/48
G01N033/50
A61B003/10

US Classification:

702/019000, 351/205000

Abstract:

A system to detect eye disease in which monochromatic laser light is directed into the vitreous humor after passing through the front of the eye. A very sensitive detection system then detects the light scattered from the vitreous humor as it exits the eye. The light is scattered at a wavelength different from that of the laser in a manner known as Raman scattering. The wavelength of the Raman scattered photons are shifted by vibrational modes of the molecules, and this shift is a characteristic feature of the molecules interacting with the light. In this way, the Raman scattered light is essentially imprinted with a fingerprint of relevant molecules. As it exits the eye, this Raman scattered light can be separated from other types of scattered light and then routed to a detection system, wherein the results are calibrated against actual standards for the particular vitreous substances being analyzed. An optic arrangement tightly focuses the laser into the vitreous humor and thereby reduces the spectral fingerprints or noise from proteins and other molecules normally present in the lens, cornea, retina and other eye components.

US Patent:

20040176752, Sep 9, 2004

Filed:

Mar 6, 2003

Appl. No.:

10/383124

Inventors:

Robert Alfano - Bronx NY, US
Tapan Gayen - Brooklyn NY, US
Steven McCormick - New York NY, US
Richard Rosen - New York NY, US
Alvin Katz - Bronx NY, US
Howard Savage - Ossining NY, US

International Classification:

A61B018/20

US Classification:

606/004000, 606/008000

Abstract:

A system and method for exposing ocular tissue to a beam of electromagnetic radiation tuned to an NIR wavelength between about 1380 nm and about 1600 nm in the water absorption band. The laser energy is absorbed by the water, which in turn, transfers the energy to collagen molecules. The helical collagen molecules partially denature and then re-nature to form a weld across the region of the tissues to be joined. In a preferred embodiment, the electromagnetic radiation originates from a laser. The lasers may be Cr doped crystals, Erbium fibers, and alloys of semiconductor laser diodes.