Robert J Cain

US Patent:

20050164912, Jul 28, 2005

Filed:

Dec 23, 2004

Appl. No.:

11/022197

Inventors:

Roger Bigelow - Boulder CO, US
Robert Cain - Boulder CO, US

International Classification:

C07K001/02

US Classification:

514002000, 530333000

Abstract:

Methods for the solid phase synthesis of peptides and peptide intermediates, in particular methods involving recovering peptides from resin supports at excellent yield. In this invention, an alternating at least partially repeating cycle of shrinking and swelling treatments are used. Each shrinking or swelling part of a cycle may involve one or more washes. The process provides excellent recovery of peptide in a very efficient manner in terms of the number of individual washes and the total volume of wash reagents used.

US Patent:

20080154063, Jun 26, 2008

Filed:

Dec 20, 2007

Appl. No.:

12/004190

Inventors:

Robert O. Cain - Boulder CO, US
Hendrik Moorlag - Westminister CO, US
Charles E. Tucker - Superior CO, US

International Classification:

C07C 215/10
C07C 213/00
C07C 215/20

US Classification:

564443, 564506

Abstract:

A method of making an amino-alkylenediol and intermediate compounds useful in the method is disclosed. The method includes preparing a first intermediate compound comprising an aminoalkylene diol wherein a protecting group is linked to the amino functionality, and optionally, preparing a second intermediate compound comprising a salt of the first intermediate compound.The first intermediate compound has the structurewherein R is a divalent alkylene radical having from 2 to 20 carbon atoms, X and Y are independently a divalent linking moiety or a single bond, and Z is a protecting group.The second intermediate compound has the structurewherein R is a divalent alkylene radical having from 2 to 20 carbon atoms, X and Y are independently a divalent linking moiety or a single bond, TsO is toluene sulfonate, and Z is a protecting group.