Robert A Dow

US Patent:

6380223, Apr 30, 2002

Filed:

Apr 27, 2000

Appl. No.:

09/559384

Inventors:

Robert L. Dow - Waterford CT
Kevin K. Liu - East Lyme CT
Bradley P. Morgan - Lyme CT
Andrew G. Swick - East Lyme CT

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D21302

US Classification:

514357, 546336, 544168, 544242, 544336, 548131, 5142382, 5142521, 514269, 514364

Abstract:

The present invention provides non-steroidal compounds of formula I which are selective modulators (i. e. , agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides intermediates and processes for preparing these compounds.

US Patent:

6518431, Feb 11, 2003

Filed:

Mar 28, 2001

Appl. No.:

09/820137

Inventors:

Robert L. Dow - Waterford CT
Steven R. Schneider - Stonington CT

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D40102

US Classification:

5462821, 5462831, 546339

Abstract:

A process for preparing a compound of the formula wherein n, R , R , R and X are as defined above, used as an intermediate in the synthesis of -adrenergic receptor agonists.

US Patent:

6545018, Apr 8, 2003

Filed:

Sep 27, 2001

Appl. No.:

09/966467

Inventors:

Yuan-Ching Phoebe Chiang - East Lyme CT
Robert L. Dow - Waterford CT

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D21302

US Classification:

514307, 514352, 514535, 514563, 514617, 546152, 546336, 560 19, 560143, 562433, 564155

Abstract:

The present invention provides novel compounds of the Formula and prodrugs thereof, geometric and optical isomers thereof, and pharmaceutically acceptable salts of such compounds, prodrugs and isomers, wherein R -R and W are as described herein. Pharmaceutical compositions containing such compounds, prodrugs, isomers or pharmaceutically acceptable salts thereof, and methods, pharmaceutical compositions and kits for treating obesity, hyperlipidemia, glaucoma, cardiac arrhythmia, skin disorders, thyroid disease, hypothyroidism and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, hypercholesteremia, depression and osteoporosis are also provided.

US Patent:

6657063, Dec 2, 2003

Filed:

Aug 28, 2000

Appl. No.:

09/649622

Inventors:

Robert L. Dow - Waterford CT

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D21300

US Classification:

546264, 546193, 514312, 514313, 514318, 514330, 514331

Abstract:

This invention is directed to pharmaceutical compositions comprising adrenergic agonists including (4-(2-(2-(6-aminopyridin-3-yl)-2(R)-hydroxyethylamino)ethoxy)phenyl)acetic acid and growth hormone or growth hormone secretagogues, prodrugs thereof or pharmaceutically acceptable salts of said compounds or said prodrugs. The invention is also directed to methods of using those compositions in the treatment of obesity, diabetes, hypertension and frailty in animals and particularly in humans.

US Patent:

6670480, Dec 30, 2003

Filed:

Dec 12, 2002

Appl. No.:

10/317720

Inventors:

Robert L. Dow - Waterford CT
Steven R. Schneider - Stonington CT

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D21300

US Classification:

546339, 546345

Abstract:

A process for preparing a compound of the formula wherein n, R , R , R and X are as defined above, used as an intermediate in the synthesis of -adrenergic receptor agonists.

US Patent:

6699893, Mar 2, 2004

Filed:

Feb 19, 2002

Appl. No.:

10/080174

Inventors:

Robert L. Dow - Waterford CT
Kevin K. Liu - East Lyme CT
Bradley P. Morgan - Lyme CT
Andrew G. Swick - East Lyme CT

Assignee:

Pfizer Inc - New York NY

International Classification:

C07D21302

US Classification:

514357, 5142312, 514247, 514256, 514364, 514396, 514408, 514277, 544106, 544224, 544242, 546329, 546339, 548131, 5483351, 548400

Abstract:

The present invention provides non-steroidal compounds of formula I which are selective modulators (i. e. , agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides intermediates and processes for preparing these compounds.

US Patent:

6787652, Sep 7, 2004

Filed:

Sep 27, 2000

Appl. No.:

09/671668

Inventors:

Robert L. Dow - Waterford CT
Yuan-Ching P. Chiang - East Lyme CT
Kimberly G. Estep - Groton CT

Assignee:

Pfizer, Inc. - New York NY

International Classification:

C07D253075

US Classification:

544182, 514242

Abstract:

The present invention provides novel compounds of the Formula I and prodrugs thereof, geometric and optical isomers thereof, and pharmaceutically acceptable salts of such compounds, prodrugs and isomers, wherein R to R and W are as described herein. Pharmaceutical compositions containing such compounds, prodrugs, isomers or pharmaceutically acceptable salts thereof, and methods, pharmaceutical compositions and kits for treating obesity, overweight condition, hyperlipidemia, thyroid disease, hypothyroidism, thyroid cancer and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, hypercholesteremia, depression, osteoporosis, cardiac arrhythmias, glaucoma and congestive heart failure are also provided.

US Patent:

6844441, Jan 18, 2005

Filed:

Oct 10, 2003

Appl. No.:

10/684146

Inventors:

Robert L. Dow - Waterford CT, US
Steven R. Schneider - Stonington CT, US

Assignee:

Pfizer Inc - New York NY

International Classification:

C07D21330
C07D21361

US Classification:

546339, 546345, 546346

Abstract:

A process for preparing a compound of the formula: wherein n, R, R, Rand X are as defined above, used as an intermediate in the synthesis of β-adrenergic receptor agonists.