Chung-Kuan Cheng - San Diego CA, US Hongyu Chen - La Jolla CA, US Bo Yao - La Jolla CA, US Ronald Graham - La Jolla CA, US Esther Y. Cheng - San Diego CA, US Feng Zhou - Shanghai, CN
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
H01L 29/76
US Classification:
257401, 257758, 257776, 716 12, 716 13
Abstract:
A multi-celled chip. The chip includes a plurality of hexagonal cells arranged in an array. A plurality of interconnects including Y's connect the cells in clusters of three cells each, so that each of the cells is interconnected.
Non-Fluorescent Quencher Compounds And Biomolecular Assays
Bis-diazo, triaryl and aryldiazo-N-arylphenazonium quencher moieties, substituted with electron-withdrawing and electron-donating substituents which induce polarity in the delocalized aryl/diazo ring systems, are useful as labels when attached to biomolecules such as polynucleotides, nucleosides, nucleotides and polypeptides. The quencher moieties are non-fluorescent and accept energy transfer from fluorescent reporter labels by any energy-transfer mechanism, such as FRET. Fluorescence quencher compositions are useful in preparing quencher labeled biomolecules for various molecular biology assays based on fluorescence detection.
Ronald Graham - Carlsbad CA, US Maura Barbisin - San Mateo CA, US
Assignee:
Applied Biosystems, LLC - Carlsbad CA
International Classification:
C12N 5/02
US Classification:
435375
Abstract:
Highly efficient cationic liposomes are provided as a system for the delivery to cells of agents or compounds, such as, compounds capable of silencing a target protein and enzyme substrates. The cationic liposomes can be used in methods of detecting the inhibition activity or apparent activity of a target protein in a cell, and methods of identifying a protein associated with a pathway, such as, a signal transduction pathway in a cell.
Fluorogenic Homogeneous Binding Assay Methods And Compositions
Ronald J. Graham - Carlsbad CA, US Michael M.A. Sekar - Burlingame CA, US
Assignee:
Applied Biosystems, LLC - Carlsbad CA
International Classification:
G01N 21/76
US Classification:
436172
Abstract:
Disclosed are binding substrate compositions, methods and kits useful for, among other things, detecting and/or characterizing binding interactions between molecules of interest.
The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.
Ronald Graham - Carlsbad CA, US Maura Barbisin - San Mateo CA, US
Assignee:
LIFE TECHNOLOGIES CORPORATION - Carlsbad CA
International Classification:
A61K 9/127
US Classification:
424450
Abstract:
Highly efficient cationic liposomes are provided as a system for the delivery to cells of agents or compounds, such as, compounds capable of silencing a target protein and enzyme stubstrates. The cationic liposomes can be used in methods of detecting the inhibition activity or apparent activity of a target protein in a cell, and methods of identifying a protein associated with a pathway, such as, a signal transduction pathway in a cell.
Olathe Medical ServicesCollege Point Primary Care 23450 College Blvd, Olathe, KS 66061 9137647788 (phone), 9137646088 (fax)
Education:
Medical School Kansas City University of Medicine and Biosciences College of Osteopathic Medicine Graduated: 1994
Procedures:
Destruction of Benign/Premalignant Skin Lesions Wound Care Arthrocentesis Electrocardiogram (EKG or ECG) Psychological and Neuropsychological Tests Pulmonary Function Tests Skin Tags Removal Vaccine Administration
Dr. Graham graduated from the Kansas City University of Medicine and Biosciences College of Osteopathic Medicine in 1994. He works in Olathe, KS and specializes in Family Medicine. Dr. Graham is affiliated with Olathe Medical Center.
Dr. Graham graduated from the George Washington University School of Medicine and Health Science in 1961. He works in Vancouver, WA and specializes in General Surgery. Dr. Graham is affiliated with Legacy Salmon Creek Medical Center and PeaceHealth Southwest Medical Center.
Conceived of in the 1970s, the mathematician Ronald Graham used it as part of a mathematical proof. He proposed it to solve a problem in a branch of mathematics called Ramsey theory, which deals with how to find order in chaos.