Ruiping Zhao

US Patent:

20060057206, Mar 16, 2006

Filed:

Aug 4, 2005

Appl. No.:

11/198717

Inventors:

Patrick Wong - Burlingame CA, US
Ruiping Zhao - San Jose CA, US

International Classification:

A61K 9/24

US Classification:

424473000

Abstract:

Controlled release of self-dispersing nanoparticle active agent formulations is provided by dispersing porous particles into which have been sorbed a self-dispersing nanoparticle active agent formulation in osmotic, push-layer dosage forms. The dosage forms may provide for continuous or pulsatile delivery of active agents.

US Patent:

20040142040, Jul 22, 2004

Filed:

Oct 31, 2003

Appl. No.:

10/698894

Inventors:

Liang Dong - Sunnyvale CA, US
Ruiping Zhao - Sunnyvale CA, US
Patrick Wong - Burlingame CA, US

International Classification:

A61K009/14

US Classification:

424/489000

Abstract:

The present invention provides a drug formulation and a dosage form. The drug formulation works to increase the bioavailability of hydrophobic drugs delivered to the gastro-intestinal tract (“GI tract”) of a desired subject. The drug formulation of the present invention is formulated as a self-emuslifying nanosuspension, which forms an emulsion in-situ upon introduction to an aqueous environment. The dosage form of the present invention may be formed using various different materials and may be configured to deliver the drug formulation of the present invention to the GI tract of a subject using any desired mechanism. A controlled release dosage form according to the present invention may be designed to deliver the drug formulation of the present invention at a desired rate over a desired period of time. If designed as a controlled release dosage form, the dosage form of the present invention may be an osmotic dosage form.