Ruiqin Qin Liu

US Patent:

6451575, Sep 17, 2002

Filed:

Jul 24, 1998

Appl. No.:

09/122126

Inventors:

Elizabeth C. Arner - West Grove PA
Timothy C. Burn - Hockessin DE
Robert A. Copeland - Hockessin DE
Carl P. Decicco - Newark DE
Ruiqin Liu - Hockessin DE
Ronald Magolda - Wallingford PA
Michael Pratta - Glassboro NJ
Kimberly A. Solomon - Landenburg PA
Micky D. Tortorella - Newark DE
James M. Trzaskos - Boothwyn PA
Fude Yang - Wilmington DE

Assignee:

Bristol-Myers Squibb Pharma Company - Princeton NJ

International Classification:

C12N 964

US Classification:

435226, 435212, 435219, 435183, 435 23, 530350, 424 9467

Abstract:

The invention is directed to the family of aggrecan degrading metallo proteases (ADMPs) that exhibit the ability to cleave the aggrecan core protein between amino acid residues Glu -Ala. The invention encompasses the nucleic acids encoding such enzymes, processes for production of recombinant ADMPs, compositions containing such enzymes, and the use of these enzymes in various assays and for the development of novel inhibitors for use as therapies for diseases involving aggrecanase-mediated degradation of cartilage or other aggrecanase-associated diseases.

US Patent:

6521436, Feb 18, 2003

Filed:

Aug 9, 2000

Appl. No.:

09/634286

Inventors:

Elizabeth C. Arner - West Grove PA
Timothy C. Burn - Hockessin DE
Robert A. Copeland - Hockessin DE
Carl P. Decicco - Newark DE
Ruiqin Liu - Hockessin DE
Ronald Magolda - Wallingford PA
Michael Pratta - Glassboro NJ
Kimberly A. Solomon - Landenburg PA
Micky D. Tortorella - Newark DE
James M. Trzaskos - Boothwyn PA
Fude Yang - Wilmington DE

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12N 964

US Classification:

435226, 435212, 435219, 435183, 4352523, 4353201, 435325, 536 231, 536 232, 536 235, 530350

Abstract:

The invention is directed to the family of aggrecan degrading metallo proteases (ADMPs) that exhibit the ability to cleave the aggrecan core protein between amino acid residues Glu -Ala. The invention encompasses the nucleic acids encoding such enzymes, processes for production of recombinant ADMPs, compositions containing such enzymes, and the use of these enzymes in various assays and for the development of novel inhibitors for use as therapies for diseases involving aggrecanase-mediated degradation of cartilage or other aggrecanase-associated diseases.

US Patent:

6753176, Jun 22, 2004

Filed:

Sep 19, 2002

Appl. No.:

10/247685

Inventors:

Elizabeth C. Arner - West Grove PA
Timothy C. Burn - Hockessin DE
Robert A. Copeland - Hockessin DE
Carl P. Decicco - Newark DE
Ruiqin Liu - Hockessin DE
Ronald Magolda - Wallingford PA
Michael Pratta - Glassboro NJ
Kimberly A. Solomon - Landenburg PA
Micky D. Tortorella - Newark DE
James M. Trzaskos - Boothwyn PA
Fude Yang - Wilmington DE

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12N 964

US Classification:

435226, 435212, 435219, 435183, 4352523, 4353201, 435325, 536 231, 536 232, 536 235, 530350

Abstract:

The invention is directed to the family of aggrecan degrading metallo proteases (ADMPs) that exhibit the ability to cleave the aggrecan core protein between amino acid residues Glu -Ala. The invention encompasses the nucleic acids encoding such enzymes, processes for production of recombinant ADMPs, compositions containing such enzymes, and the use of these enzymes in various assays and for the development of novel inhibitors for use as therapies for diseases involving aggrecanase-mediated degradation of cartilage or other aggrecanase-associated diseases.

US Patent:

7049412, May 23, 2006

Filed:

Aug 9, 2000

Appl. No.:

09/634287

Inventors:

Elizabeth C. Arner - West Grove PA, US
Timothy C. Burn - Hockessin DE, US
Robert A. Copeland - Hockessin DE, US
Carl P. Decicco - Newark DE, US
Ruiqin Liu - Hockessin DE, US
Ronald Magolda - Wallingford PA, US
Michael Pratta - Glassboro NJ, US
Kimberly A. Solomon - Landenburg PA, US
Micky D. Tortorella - Newark DE, US
James M. Trzaskos - Boothwyn PA, US
Fude Yang - Wilmington DE, US

Assignee:

Bristol-Myers Squibb Pharma Comp. - Princeton NJ

International Classification:

C07K 16/00

US Classification:

53038826, 5303891, 435 71, 435 74

Abstract:

The invention is directed to the family of aggrecan degrading metallo proteases (ADMPs) that exhibit the ability to cleave the aggrecan core protein between amino acid residues Glu-Ala. The invention encompasses the nucleic acids encoding such enzymes, processes for production of recombinant ADMPs, compositions containing such enzymes, and the use of these enzymes in various assays and for the development of novel inhibitors for use as therapies for diseases involving aggrecanase-mediated degradation of cartilage or other aggrecanase-associated diseases.

US Patent:

7223834, May 29, 2007

Filed:

Oct 12, 2001

Appl. No.:

09/975813

Inventors:

Jeffrey A. Miller - Lincoln University PA, US
Elizabeth C. Arner - West Grove PA, US
Robert A. Copeland - Hockessin DE, US
Gary L. Davis - Claymont DE, US
Ruiqin Liu - Hockessin DE, US
Michael A. Pratta - Glassboro NJ, US
Micky D. Tortorella - Newark DE, US

Assignee:

Bristol-Myers Squibb Pharma Company - Princeton NJ

International Classification:

A61K 38/00
A61K 38/17
C12N 9/00
C12N 9/14

US Classification:

530300, 435183, 435195, 530356

Abstract:

This invention is directed to assays to determine the presence or absence of proteins that exhibit aggrecanase or ADMP activity. This invention also relates to peptides that acts as a substrates for ADMPs, their use in various assays to determine the presence or absence of ADMP activity, and their use as inhibitors of ADMP activity.

US Patent:

20070238136, Oct 11, 2007

Filed:

Apr 10, 2007

Appl. No.:

11/733232

Inventors:

Jeffrey Miller - Lincoln University PA, US
Elizabeth Arner - West Grove PA, US
Robert Copeland - Hockessin DE, US
Gary Davis - Lincoln University DE, US
Ruiqin Liu - Hockessin DE, US
Michael Pratta - Glassboro NJ, US
Micky Tortorella - Newark DE, US

International Classification:

G01N 33/53
C12Q 1/34

US Classification:

435007500, 435018000, 435007100

Abstract:

This invention is directed to assays to determine the presence or absence of proteins that exhibit aggrecanase or ADMP activity. This invention also relates to peptides that acts as a substrates for ADMPs, their use in various assays to determine the presence or absence of ADMP activity, and their use as inhibitors of ADMP activity.

US Patent:

63261626, Dec 4, 2001

Filed:

Jul 24, 1998

Appl. No.:

9/122127

Inventors:

Jeffrey A. Miller - Lincoln University PA
Elizabeth C. Arner - West Grove PA
Robert A. Copeland - Hockessin DE
Gary L. Davis - Claymont DE
Ruiqin Liu - Hockessin DE
Michael Pratta - Glassboro NJ
Micky D. Tortorella - Newark DE

Assignee:

Bristol-Myers Squibb Pharma Company - Princeton NJ

International Classification:

C12Q 137

US Classification:

435 23

Abstract:

This invention is directed to assays to determine the presence or absence of proteins that exhibit aggrecanase or ADMP activity. This invention also relates to peptides that acts as a substrates for ADMPs, their use in various assays to determine the presence or absence of ADMP activity, and their use as inhibitors of ADMP activity.