Samuel Rabkin from Boston, MA

Use Of Soluble Costimulatory Factor For Tumor Immuno-Gene Therapy
view source
US Patent:

7064111, Jun 20, 2006
Filed:

Oct 5, 2000
Appl. No.:

09/679147
Inventors:

Tomoki Todo - Belmont MA, US
Samuel D. Rabkin - Lynn MA, US
Robert L. Martuza - Cambridge MA, US
Assignee:

Georgetown University - Washington DC
International Classification:

A61K 48/00
A61K 39/12
A61K 39/245
C12N 15/00
C12N 5/00
US Classification:

514 44, 4353201, 435325, 435455, 4241991, 4242311, 4241341
Abstract:

A new gene therapy entails tumor treatment by introducing an expressible nucleotide sequence for a soluble costimulatory factor, thereby enhancing the response of T-cells to a tumor. In vivo expression of the soluble factor overcomes anergy or tolerance to tumor cells and activates T-cells that are infiltrating or surrounding the tumor. A pharmaceutical composition containing such a gene is effective in tumor suppression.

Viral Vectors And Their Use In Therapeutic Methods
view source
US Patent:

7749745, Jul 6, 2010
Filed:

Mar 27, 2002
Appl. No.:

10/107036
Inventors:

Paul Johnson - Vancouver, CA
Robert L. Martuza - Cambridge MA, US
Samuel D. Rabkin - Lynn MA, US
Tomoki Todo - Belmont MA, US
Assignee:

Georgetown University - Washington DC
The General Hospital Corporation - Boston MA
MediGene, Inc. - San Diego CA
International Classification:

C12N 7/00
C12N 7/01
A61K 39/245
US Classification:

4352351, 4353201, 435440, 435455, 4242051, 4242311, 424 932, 424 936
Abstract:

The invention provides viral vectors (e. g. , herpes viral vectors) and methods of using these vectors to treat disease.

Oncolytic Herpes Simplex Virus Immunotherapy In The Treatment Of Brain Cancer
view source
US Patent:

8313896, Nov 20, 2012
Filed:

Apr 6, 2009
Appl. No.:

12/384633
Inventors:

Robert L. Martuza - Marblehead MA, US
Samuel Rabkin - Swampscott MA, US
William Curry - Boston MA, US
Christopher Farrell - Brookline MA, US
Cecile Zaupa - Bassoues, FR
Assignee:

The General Hospital Corporation - Boston MA
International Classification:

C12Q 1/70
US Classification:

435 5
Abstract:

Method of stimulating an immune response (e. g. , to treat cancer) include administering to a subject a composition including dendritic cells incubated with (i) oHSV-infected tumor cells or a composition derived therefrom, or (ii) tumor cells plus oHSV, as well as methods of preparing such compositions, are described.

Viral Vectors And Their Use In Therapeutic Methods
view source
US Patent:

8470577, Jun 25, 2013
Filed:

Mar 11, 2010
Appl. No.:

12/721599
Inventors:

Paul Johnson - Vancouver, CA
Robert L. Martuza - Cambridge MA, US
Samuel D. Rabkin - Lynn MA, US
Tomoki Todo - Belmont MA, US
Assignee:

Catherex, Inc. - Dover DE
The General Hospital Corporation - Boston MA
Georgetown University - Washington DC
International Classification:

C12N 7/00
C12N 7/01
A61K 39/245
US Classification:

4352351, 4353201, 435440, 435456, 4242051, 4242311, 424 932, 424 936
Abstract:

The invention provides viral vectors (e. g. , herpes viral vectors) and methods of using these vectors to treat disease.

Use On Oncolytic Herpes Viruses For Killing Cancer Stem Cells
view source
US Patent:

20110177032, Jul 21, 2011
Filed:

May 4, 2009
Appl. No.:

12/994960
Inventors:

Robert Martuza - Marblehead MA, US
Samuel Rabkin - Swampscott MA, US
Hiroaki Wakimoto - Newton MA, US
Ryuichi Kanai - Brookline MA, US
Assignee:

The General Hospital Corporation d/b/a Massachusetts General Hospital - Boston MA
International Classification:

A61K 35/76
C12N 5/071
A61P 35/00
C12Q 1/70
US Classification:

424 932, 435375, 435 5
Abstract:

The invention, in some aspects, relates to the selective killing of cancer stem cells by oncolytic Herpes virus mediated oncolysis. In some aspects, the invention relates to methods for treating a subject having a cancer stem cell by administering to the subject an oncolytic Herpes virus. In other aspects, the invention provides methods for evaluating the efficacy of an oncolytic Herpes virus for killing cancer stem cells.

10:30am Worship Service Bishop Samuel R. Blakes Message: WHO'S IN YOUR...

7:00pm Tuesday Bible Study Bishop Samuel R. Blakes Message: REFOCUSING...

I do love this artist,who paints the former shtetls and I dream of an ...

As part of the 2021 #OpenToChange initiative in partnership with Conve...

Grandmaster Ben Finegold pays tribute to former U.S. Champion Sam Resh...

FCR 3: Samuel Ericsson vs Ruben Sibma #FCRMMA #KARATECOMBAT #SAMUELERI...

Work:

Revolution Prep - Private Tutor

Education:

Cornell University

Samuel Rabkin