Sandra L Erickson

US Patent:

6579974, Jun 17, 2003

Filed:

Jun 8, 1999

Appl. No.:

09/328857

Inventors:

Sylvaine Cases - San Francisco CA
Sandra K. Erickson - San Francisco CA

Assignee:

The Regents of The University of California - Oakland CA
The United States of America as represented by the Department of Veterans Affairs - Washington DC

International Classification:

C07H 2102

US Classification:

536 231, 536 235, 536 232, 536 234, 435 691, 435193, 435348, 4353201, 4352523

Abstract:

Nucleic acid compositions encoding novel ACAT proteins, as well as the novel ACAT-2 proteins, (ACAT-2) are provided. Also provided are methods of producing the subject nucleic acid and protein compositions. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications, as well as in treatment therapies for disease conditions associated with ACAT-2 activity.

US Patent:

6869937, Mar 22, 2005

Filed:

Jun 27, 2000

Appl. No.:

09/605166

Inventors:

Sylvaine Cases - San Francisco CA, US
Sandra K. Erickson - San Francisco CA, US
Sabine Novak - Munich, DE
Michel Accad - San Francisco CA, US

Assignee:

The Regents of the Universtiy of California - Oakland CA
The United States of America as represented by the Department of Veteran Affairs - Washington DC

International Classification:

A01N043/04
A61K031/70
A61K038/00
C12N009/00
C12N005/00

US Classification:

514 44, 514 12, 536 231, 536410, 536 232, 536348, 536 235, 435 32, 435377, 4352523, 435193

Abstract:

Nucleic acid compositions encoding novel ACAT proteins, as well as the novel ACAT-2 proteins, (ACAT-2) are provided. Also provided are methods of producing the subject nucleic acid and protein compositions. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including diagnostic and therapeutic agent screening applications, as well as in treatment therapies for disease conditions associated with ACAT-2 activity, e. g. , in the treatment of gall stones.

US Patent:

7238779, Jul 3, 2007

Filed:

Feb 12, 2004

Appl. No.:

10/779251

Inventors:

Sylvaine Cases - San Francisco CA, US
Sandra K. Erickson - San Francisco CA, US
Sabine Novak - Munich, DE
Michel Accad - San Francisco CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C07K 1/00
C07K 14/00
C07K 17/00
A61K 38/00
A61K 38/16
C12Q 1/48
C12N 15/09

US Classification:

530350, 530300, 530344, 514 2, 514 8, 435 771, 435 15, 435 692

Abstract:

Nucleic acid compositions encoding novel ACAT proteins, as well as the novel ACAT-2 proteins, (ACAT-2) are provided. Also provided are methods of producing the subject nucleic acid and protein compositions. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including diagnostic and therapeutic agent screening applications, as well as in treatment therapies for disease conditions associated with ACAT-2 activity, e. g. , in the treatment of gall stones.

US Patent:

7745691, Jun 29, 2010

Filed:

Dec 12, 2006

Appl. No.:

11/609810

Inventors:

Hubert C. Chen - Newbury Parl CA, US
Steven J. Smith - San Francisco CA, US
Sylvaine Cases - Belmont CA, US
Sandra K. Erickson - San Francisco CA, US

Assignee:

The Regents of the University of California - Oakland CA
The United States of America as represented by the Department of Veterans Affairs - Washington DC
The J. David Gladstone Institutes - San Francisco CA

International Classification:

A01K 67/027
A01K 67/00
G01N 33/00

US Classification:

800 18, 800 8, 800 3

Abstract:

Methods and compositions for modulating carbohydrate metabolism in a host are provided. In the subject methods, diacylglycerol acyltransferase (DGAT) activity (specifically DGAT1 activity) is modulated, e. g. , reduced or enhanced, to achieve a desired insulin and/or leptin sensitivity, thereby modulating carbohydrate metabolism, e. g. , increasing or decreasing blood glucose levels, glucose uptake into cells and assimilation into glycogen. Also provided are pharmaceutical compositions for practicing the subject methods. The subject methods and compositions find use in a variety of applications, including the treatment of hosts suffering conditions associated with abnormal carbohydrate metabolism, such as obesity or diabetes.

US Patent:

20030072757, Apr 17, 2003

Filed:

Oct 16, 2002

Appl. No.:

10/273438

Inventors:

Robert Farese - San Francisco CA, US
Sylvaine Cases - Belmont CA, US
Steven Smith - San Francisco CA, US
Sandra Erickson - Mountain View CA, US

International Classification:

G01N033/53
A01K067/027
A61K039/395
C12N005/06
C07K016/40

US Classification:

424/146100, 530/388260, 435/338000, 435/007100

Abstract:

Nucleic acid compositions encoding polypeptide products with diglyceride acyltransferase activity, as well as the polypeptide products encoded thereby and methods for producing the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications, as well as in treatment therapies and in the production of triacylglycerols.

US Patent:

20030167483, Sep 4, 2003

Filed:

Oct 29, 2001

Appl. No.:

10/040315

Inventors:

Robert Farese - San Francisco CA, US
Sylvaine Cases - Belmont CA, US
Steven Smith - San Francisco CA, US
Sandra Erickson - Mountain View CA, US

International Classification:

A01K067/027
C12N015/85

US Classification:

800/009000, 800/014000, 800/018000, 435/320100, 435/455000

Abstract:

Nucleic acid compositions encoding polypeptide products with diglyceride acyltransferase activity, as well as the polypeptide products encoded thereby and methods for producing the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications, as well as in treatment therapies and in the production of triacylglycerols.

US Patent:

20040078836, Apr 22, 2004

Filed:

Sep 10, 2003

Appl. No.:

10/659800

Inventors:

Robert Farese - San Francisco CA, US
Sylvaine Cases - Belmont CA, US
Steven Smith - San Francisco CA, US
Sandra Erickson - San Francisco CA, US

International Classification:

A01K067/027
A61K039/395

US Classification:

800/014000, 424/146100

Abstract:

Nucleic acid compositions encoding polypeptide products with diglyceride acyltransferase activity, as well as the polypeptide products encoded thereby and methods for producing the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications, as well as in treatment therapies and in the production of triacylglycerols.

US Patent:

6344548, Feb 5, 2002

Filed:

Jun 24, 1998

Appl. No.:

09/103754

Inventors:

Sylvaine Cases - San Francisco CA
Steven Smith - San Francisco CA
Sandra K. Erickson - San Francisco CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C07H 2104

US Classification:

536 232

Abstract:

Nucleic acid compositions encoding polypeptide products with diglyceride acyltransferase activity, as well as the polypeptide products encoded thereby and methods for producing the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications, as well as in treatment therapies and in the production of triacylglycerols.