Anthony E. Ting - Shaker Heights OH, US Robert W. Mays - Shaker Heights OH, US Jason A. Hamilton - Shaker Heights OH, US Sarah P. Busch - Cleveland OH, US Jerry Silver - Bay Village OH, US
Assignee:
Case Western Reserve University - Cleveland OH ABT Holding Company - Cleveland OH
The invention provides methods for treating pathological conditions associated with an undesirable inflammatory component. The invention is generally directed to reducing inflammation by administering cells that modulate macrophage activation. The invention is also directed to drug discovery methods to screen for agents that modulate the ability of the cells to modulate macrophage activation. The invention is also directed to cell banks that can be used to provide cells for administration to a subject, the banks comprising cells having desired potency to modulate macrophage activation.
The invention is generally directed to treatment of neuronal injury. In particular, the invention is directed to reducing axonal retraction (“dieback”) that occurs as a result of the interaction of activated macrophages with dystrophic axons that are produced during nervous system acute or chronic injury. The invention is also directed to promoting axonal growth/regeneration. The invention is specifically directed to using stem cells or their secreted cellular factors, such as would be produced in conditioned cell culture medium, to ameliorate or prevent axonal dieback and/or promote growth/regeneration of axons.
Sarah A. BUSCH - Cleveland OH, US Kevin P. Horn - Salt Lake City UT, US Robert W. Mays - Shaker Heights OH, US Jerry Silver - Bay Village OH, US
Assignee:
ABT Holding Company - Cleveland OH Case Western Reserve University - Cleveland OH
International Classification:
A61K 35/28
US Classification:
424 937, 424577
Abstract:
The invention is generally directed to treatment of neuronal injury. In particular, the invention is directed to reducing axonal retraction (“dieback”) that occurs as a result of the interaction of activated macrophages with dystrophic axons that are produced during nervous system acute or chronic injury. The invention is also directed to promoting axonal growth/regeneration. The invention is specifically directed to using stem cells or their secreted cellular factors, such as would be produced in conditioned cell culture medium, to ameliorate or prevent axonal dieback and/or promote growth/regeneration of axons.
Sarah A. BUSCH - Cleveland OH, US Kevin P. Horn - Gahann OH, US Robert W. Mays - Shaker Heights OH, US Jerry Silver - Bay Village OH, US
Assignee:
Case Western Reserve University - Cleveland OH ABT Holding Company - Cleveland OH
International Classification:
A61K 35/12
US Classification:
424 937, 514 177, 514 179
Abstract:
The invention is generally directed to treatment of neuronal injury. In particular, the invention is directed to reducing axonal retraction (“dieback”) that occurs as a result of the interaction of activated macrophages with dystrophic axons that are produced during nervous system acute or chronic injury. The invention is also directed to promoting axonal growth/regeneration. The invention is specifically directed to using stem cells or their secreted cellular factors, such as would be produced in conditioned cell culture medium, to ameliorate or prevent axonal dieback and/or promote growth/regeneration of axons.
Resumes
Senior Scientist, Regenerative Medicine At Athersys, Inc.
Joining Silver and Lang in this research effort are contributing authors Jared Cregg, Marc DePaul and Amanda Tran, all of the Department of Neurosciences, Case Western Reserve University School of Medicine; Sarah Busch, PhD, of Athersys; Kui Xu and Yingjie Shen, PhD, both of the Center for Brain and
Date: Dec 04, 2014
Category: Health
Source: Google
Youtube
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Sarah Busch full interview on 12/14/20.
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