Anthony E. Ting - Shaker Heights OH, US Robert W. Mays - Shaker Heights OH, US Jason A. Hamilton - Shaker Heights OH, US Sarah P. Busch - Cleveland OH, US Jerry Silver - Bay Village OH, US
Assignee:
Case Western Reserve University - Cleveland OH ABT Holding Company - Cleveland OH
The invention provides methods for treating pathological conditions associated with an undesirable inflammatory component. The invention is generally directed to reducing inflammation by administering cells that modulate macrophage activation. The invention is also directed to drug discovery methods to screen for agents that modulate the ability of the cells to modulate macrophage activation. The invention is also directed to cell banks that can be used to provide cells for administration to a subject, the banks comprising cells having desired potency to modulate macrophage activation.
The invention is generally directed to treatment of neuronal injury. In particular, the invention is directed to reducing axonal retraction (“dieback”) that occurs as a result of the interaction of activated macrophages with dystrophic axons that are produced during nervous system acute or chronic injury. The invention is also directed to promoting axonal growth/regeneration. The invention is specifically directed to using stem cells or their secreted cellular factors, such as would be produced in conditioned cell culture medium, to ameliorate or prevent axonal dieback and/or promote growth/regeneration of axons.
Sarah A. BUSCH - Cleveland OH, US Kevin P. Horn - Salt Lake City UT, US Robert W. Mays - Shaker Heights OH, US Jerry Silver - Bay Village OH, US
Assignee:
ABT Holding Company - Cleveland OH Case Western Reserve University - Cleveland OH
International Classification:
A61K 35/28
US Classification:
424 937, 424577
Abstract:
The invention is generally directed to treatment of neuronal injury. In particular, the invention is directed to reducing axonal retraction (“dieback”) that occurs as a result of the interaction of activated macrophages with dystrophic axons that are produced during nervous system acute or chronic injury. The invention is also directed to promoting axonal growth/regeneration. The invention is specifically directed to using stem cells or their secreted cellular factors, such as would be produced in conditioned cell culture medium, to ameliorate or prevent axonal dieback and/or promote growth/regeneration of axons.
Sarah A. BUSCH - Cleveland OH, US Kevin P. Horn - Gahann OH, US Robert W. Mays - Shaker Heights OH, US Jerry Silver - Bay Village OH, US
Assignee:
Case Western Reserve University - Cleveland OH ABT Holding Company - Cleveland OH
International Classification:
A61K 35/12
US Classification:
424 937, 514 177, 514 179
Abstract:
The invention is generally directed to treatment of neuronal injury. In particular, the invention is directed to reducing axonal retraction (“dieback”) that occurs as a result of the interaction of activated macrophages with dystrophic axons that are produced during nervous system acute or chronic injury. The invention is also directed to promoting axonal growth/regeneration. The invention is specifically directed to using stem cells or their secreted cellular factors, such as would be produced in conditioned cell culture medium, to ameliorate or prevent axonal dieback and/or promote growth/regeneration of axons.
Resumes
Senior Scientist, Regenerative Medicine At Athersys, Inc.
Marketing Communications Event Management Website Management Strategic Planning Social Media Public Relations Brand Management Marketing Strategy Email Marketing Small Business Development Trade Show Management Channel Management Copywriting CRM Database Management Market Research SEO Website Copy Online Marketing Direct Marketing Online Advertising Trade Shows Business Development New Business Development Advertising Strategy
Maplewood Career Center Ravenna, OH Aug 2011 to Jun 2012 Career with young children preschool
Education:
Maplewood Career Center High School Ravenna, OH 2011 to 2013 None at the moment in Career with Young Children
Skills:
Working with kids
Name / Title
Company / Classification
Phones & Addresses
Sarah Busch Administrator, Chairman, Executive
Graphic Enterprises Business Supplies and Equipment · Sales And Service Large Format Printers And Copiers · Whol Office Equipment · Whole Office Equipment · Office Machines, NEC (except t
3874 Highland Park NW, North Canton, OH 44720 3874 Highland Park Nw , North Canton, OH 44720 3874 Highland Park Nw , North Canton, OH 44720 1012 Marquez Pl STE .106-B , Santa Fe, NM 87505 3304949694, 8005536616, 3304941294, 3304945481
Jason Lewis, Chastity Jellison, Meagon Bradley, Dell Berry, Kathryn Bernard, Matt Moo, Kevin Clurke, Shatiqua Mosby, Kim Curless, Chris Guard, Lucille Greene
Joining Silver and Lang in this research effort are contributing authors Jared Cregg, Marc DePaul and Amanda Tran, all of the Department of Neurosciences, Case Western Reserve University School of Medicine; Sarah Busch, PhD, of Athersys; Kui Xu and Yingjie Shen, PhD, both of the Center for Brain and