Shalini Singh

US Patent:

20210063403, Mar 4, 2021

Filed:

Oct 21, 2020

Appl. No.:

16/949252

Inventors:

- Tucson AZ, US
Zhiming Liao - Livermore CA, US
Andrea Muranyi - Tucson AZ, US
Kandavel Shanmugam - Oro Valley AZ, US
Shalini Singh - Tucson AZ, US
Yifei Zhu - San Jose CA, US

International Classification:

G01N 33/574
C07K 16/22
C07K 16/30

Abstract:

The invention provides anti-human pro-epiregulin and anti-human amphiregulin antibodies and methods of using the same. Anti-EREG antibodies raised against amino acids 148-169 and 156-169 of the human EREG protein, and anti-AREG antibodies raised against amino acids 238-252 of the human AREG protein are disclosed. Methods of using these antibodies to detect EREG and AREG and kits and other products for performing such methods are also disclosed.

US Patent:

20170309021, Oct 26, 2017

Filed:

Jun 30, 2017

Appl. No.:

15/640412

Inventors:

- Tucson AZ, US
Ting Chen - Sunnyvale CA, US
Shalini Singh - Tucson AZ, US
Alisa Tubbs - Phoenix AZ, US

International Classification:

G06T 7/00
G06T 7/00
G06F 19/00

Abstract:

Described herein are methods for co-expression analysis of multiple markers in a tissue sample comprising: computing a heat map of marker expression for each of a plurality of single marker channel images, wherein each of the plurality of single marker channel images comprise a single marker; identifying one or more candidate regions of interest in each heat map of marker expression; computing overlay masks comprising the identified one or more candidate regions of interest from each heat map of marker expression; determining one or more co-localized regions of interest from the overlay masks; mapping the one or more co-localized regions of interest to a same coordinate position in each of the plurality of single marker channel images; and estimating a number of cells in at least one of the determined one or more co-localized regions of interest in each of the plurality of single marker channel images.