Sharon K Graham

US Patent:

60336854, Mar 7, 2000

Filed:

Jun 29, 1998

Appl. No.:

9/106658

Inventors:

Yihong Qiu - Gurnee IL
Jay S. Trivedi - Skokie IL
Sharon L. Graham - Roselle IL
Kolette M. Flood - Crystal Lake IL
Steven L. Krill - Gurnee IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 920

US Classification:

424464

Abstract:

The present invention provides a tablet for the controlled release of an active agent comprising (a) a matrix layer comprising an active agent embedded in a non-swelling, non-gelling hydrophobic matrix; (b) a first barrier layer laminated to a single face of the matrix layer; and (c) an optional second barrier layer laminated to the opposite face of the matrix layer and oppositely disposed to the first barrier layer; wherein the matrix comprises up to about 80% active agent and from about 5% to about 80% by weight of nonswellable waxes or polymeric material insoluble in aqueous medium, and the first and second barrier layers independently comprise (1) polymeric material exhibiting a high degree of swelling and gelling in aqueous medium or (2) nonswellable wax or polymeric material insoluble in aqueous medium.